Forging a link between biofilms and disease.
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Biomedical subjects
Publications and source records attributed to C Potera.
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Cockroach antigens (proteins found in the insects' feces, saliva, eggs, and shed cuticles) have been implicated as one of the leading causes of asthma among inner-city children. These antigens can trigger severe allergic reactions, and even tiny amounts can be potentially fatal to sensitive asthmatics.
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Plasma amino acids were determined before and after orally administered alanine loads in five women using an estrogen-containing oral contraceptive and four healthy female controls. Oral contraceptive users and significant reductions in fasting plasma valine, methionine, isoleucine, tyrosine, phenylalanine, histidine, glutamic acid, and alpha-aminobutyric acid. With the exception of alpha-aminobutyric acid, these differences between the two groups were eliminated within 3 hr of alanine ingestion. This effect was due to a gradual increase in the plasma amino acids of the oral contraceptive-treated women, plus no change or slight reductions in the controls.
The plasma pyridoxal phosphate concentration was determined in 30 cases of early breast cancer, 21 patients with locally recurrent disease, and 43 patients with systemic metastases. The two groups of advanced breast cancer had significantly lower plasma pyridoxal phosphate levels than 36 healthy women of similar age. Urinary 4-pyridoxic acid excretion was normal in breast cancer. Plasma pyridoxal phosphate concentrations were also reduced in 34 women with widespread cancer derived from primary sites other than breast, but were normal in 39 with early disease.
Plasma alanine or glycine concentrations and blood pyruvate were studied before and after oral administration of the two amino acids to women using estrogen-containing oral contraceptives and to a control group of women. Thirty oral contraceptive users and 14 controls received alanine loads (200 mg/kg of body weight). The two groups had similar fasting plasma alanine levels, but the fasting blood pyruvate was elevated in the contraceptive steroid-treated women. After alanine ingestion, the increases in plasma alanine were significantly lower in the oral contraceptive users. Both groups showed a rise in blood pyruvate; there were no differences in the increments above fasting values. Treatment with pyridoxine hydrochloride, 25 mg for 4 weeks, had not effect on the responses of 11 oral contraceptive users to alanine loading. Twenty-four oral contraceptive users and 14 controls were studied before and after a glycine load (140 mg/kg of body weight). The fasting plasma glycine levels were similar, but lesser increases after ingestion of the amino acid occurred in the oral contraceptive-treated group. Blood pyruvate concentrations in both oral contraceptive users and controls were unaffected by oral glycine loads.