Biomedical subjects

C Power

Publications and source records attributed to C Power.

At least 19 recordsLinked to original sources

PubMed1992

Explaining social class differences in psychological health among young adults: a longitudinal perspective.

The relationship between psychological health and occupational class was investigated in the large British sample of 23-year-old subjects from the 1958 birth cohort study. Odds of poor psychological health indicated by (1) the Malaise Inventory and (2) seeking help for a psychological problem between ages 16 and 23] were significantly greater in classes IV and V than in classes I and II: odds ratios were (1) 3.90 and 5.84, (2) 2.32 and 2.33 for men and women, respectively. Explanations for these differences were examined using longitudinal data representing 'inheritance' at birth, socio-economic background, educational achievement, earlier health and behaviour. The analyses suggested that each of these contributes to class differences in psychological health. Behaviour at age 16 (identified from the Rutter Behaviour Scale) was particularly notable for both psychological measures, as were educational achievement (for Malaise) and unemployment (for psychological morbidity needing specialist help). Mechanisms by which such factors might operate are discussed. Having accounted for earlier circumstances, class differences were no longer significant, except for Malaise in women. In this case an odds ratio of more than twofold remained after adjusting for earlier circumstances.

Adult↗

PubMed1992

A review of child health in the 1958 birth cohort: National Child Development Study.

In the week 3-9 March 1958, 98% of all births in England, Scotland and Wales (approximately 17,000) were studied in the Perinatal Mortality Survey. The follow-up of surviving children, known as the National Child Development Study, comprises four major sweeps at ages 7, 11, 16 and 23. Medical examinations were conducted at each age, except at 23 when health was self-reported. Details of the child's family background and socio-economic circumstances were recorded, together with assessments of their social development and educational attainment. Seventy-six per cent of the target population were interviewed at age 23. The health of subjects in the 1958 cohort has been described in over 200 publications but there is no comprehensive account of findings from birth to age 23. This overview attempts to redress this. As new data are gathered from the study subjects at age 33, opportunities will exist to investigate associations between childhood factors and health in midlife. Data on their partners and children will be included, allowing studies of inter-generational and family health. Further indications of changing illness patterns will be possible from comparisons with data collected on earlier and later born cohorts.

Accidents↗

PubMed1992

T-cell dominated inflammatory reactions in the bronchi of asthmatics are not reflected in matched bronchoalveolar lavage specimens.

Samples of bronchoalveolar lavage (BAL) and endobronchial biopsies were obtained from five patients with clinically diagnosed asthma (ATS criteria). A comparison was made of the presence and distribution of immunocompetent lymphocytes and macrophages within each sample. Significantly raised numbers of T lymphocytes, CD45RO+ lymphocytes, RFD1+ macrophage-like cells and RFD7+ macrophages were seen in the bronchial biopsies. In contrast four out of five of the BAL specimens showed a normal differential cell count, the one exception being a patient exhibiting a degree of lymphocytosis. Further, immunocytological investigation demonstrated a normal distribution of T-cell subsets and macrophage subsets in asthmatic BAL with the exception that in four out of five of these patients a raised number of macrophage-like cells exhibiting phenotypic markers of monocytes was observed. Correlation between BAL and biopsy data was seen in the number of CD45RO+ T-cells present. No other parameters exhibited a significant correlation. Raised expression of HLA-DR was recorded in all asthmatic biopsies, yet lavage cells from the same patients failed to exhibit any increase of HLA-DR density over normal. It is concluded that the immune-associated inflammation present in endobronchial biopsies of clinically stable asthmatics is not reflected in bronchoalveolar lavage samples taken from the same patients.

Acute-Phase Reaction↗

PubMed1991

Structural and functional studies of the endothelial activation antigen endothelial leucocyte adhesion molecule-1 using a panel of monoclonal antibodies.

We have produced a panel of mAb to the endothelial activation Ag endothelial leucocyte adhesion molecule-1 (ELAM-1), using both a conventional immunization protocol and one involving immunosuppression. By constructing ELAM-1 mutants we have demonstrated that seven of these antibodies recognize epitopes within the lectin domain of ELAM-1 and that one binds within the complement regulatory protein domains. These studies also suggest that the EGF-like domain is important in maintaining the conformation of the neighbouring lectin domain. In functional studies, U937 cells bound to Cos cells expressing either ELAM-1 or ELAM-1 with the complement regulatory protein domains deleted. No adhesion was observed to Cos cells expressing ELAM-1 mutants lacking either the lectin or EGF-like domains. The fact that antibodies directed against the lectin domain can inhibit adhesion suggest that this domain is directly involved in cell binding.

Antibodies, Monoclonal↗

PubMed1991

Women's lung cancer mortality, socio-economic status and changing smoking patterns.

Mortality data from the OPCS Longitudinal Study were used to determine whether the conventional classification of married women by their husband's occupation under-estimates the extent of social differences in lung cancer among this group. Differences existed for social class measures but alternatives based on housing tenure and car access defined socio-economic differences wider than any other previously recorded for England and Wales: married women living in rented housing and without a car were two and a half times as likely to die from lung cancer than those in owner occupied housing with access to a car. In 1957 and 1974 mothers of children included in the 1958 cohort study showed parallel socio-economic differences in smoking patterns as well as in uptake and cessation rates. Data from the General Household Survey for 1982 similarly suggest that cigarette smoking is more sharply differentiated using household rather than occupational measures of class. This suggests that wide differences in mortality are likely to persist through the eighties and beyond.

Adult↗

PubMed1991

Social and economic background and class inequalities in health among young adults.

This paper considers which socio-economic factors in childhood and early adulthood are most strongly associated with social class differences in health at age 23. Longitudinal data from the 1958 (NCDS) cohort were used for this purpose. By age 23 class gradients were evident for several health measures, including self-rated health, 'malaise', psychological morbidity and height. The contribution of earlier socio-economic background was established by assessing how far class differences in the health indicators were reduced by controlling for earlier circumstances. While class differentials were not eliminated after taking account of earlier circumstances, substantial reductions were associated with a number of factors in childhood, in particular social class, housing tenure, crowding, family size and receipt of free school meals. More recent experiences of unemployment and family formation were also important.

Adult↗

PubMed1991

Pathological and molecular biological features of a myelopathy associated with HTLV-1 infection.

We report the pathological and molecular biological findings of human T-cell lymphotropic virus type 1 (HTLV-1) infection of the spinal cord in a patient with a chronic progressive myelopathy. Light microscopy disclosed loss of myelin and axons, thickening of blood vessels and a lymphocytic cell infiltrate in the spinal cord especially at the cervical and thoracic levels. Electron microscopy confirmed the vascular appearance seen with light microscopy but virus particles were not observed. The HTLV-1 gag gene could be amplified (by polymerase chain reaction) from cervical spinal cord tissue while not from elsewhere in the neuroaxis. The presence of HTLV-1 genomic material in spinal cord tissue has not been previously reported.

DNA, Viral↗

PubMed1991

Secular trends in social class and sex differences in adult height.

Trends in social class and sex differences in adult mean height in Great Britain since the turn of the century were investigated using data from parents and offspring in the 1946 and 1958 British birth cohort studies (n = 50,000). There has been an increase of 1.09 cm per decade in the mean height of men but only 0.36 cm per decade in the mean height of women. On average men from non-manual origins were 1.97 cm taller than men from manual origins and the figure for women was 1.61 cm. Trends in class differences in height for those born between the beginning of the century and 1958 have been small; fluctuations have occurred over the period but were unsynchronized for men and women.

Adult↗

PubMed1991

Family disruption in early life and drinking in young adulthood.

The relationship between family disruption early in life and subsequent drinking in young adulthood was examined in a large representative British sample. Contrary to popular belief, parental loss was not an antecedent to heavy drinking in young adults. This finding was observed within social class of origin groups and when the nature and timing of the disruption were considered separately.

Adult↗

PubMed1991

T cell dominated inflammatory reactions in the bronchioles of asymptomatic asthmatics are also present in the nasal mucosa.

Endobronchial and nasal mucosa biopsies were obtained from 5 patients with clinically-stable, diagnosed asthma (ATS criteria). A comparison was made of the presence and distribution of immunocompetent lymphocytes and macrophages within each sample. The distribution of immunocompetent cells within the nasal biopsies of the asthmatic patients reflected a very similar inflammatory infiltrate to that seen in the bronchial biopsies. Significantly raised numbers of T lymphocytes, CD45RO + lymphocytes, RFD1 + macrophage-like cells and RFD7 + macrophages were seen in both the nasal mucosa and the bronchial biopsies. Increases in HLA-DR expression were also seen in the nasal mucosa biopsies from asthmatics although the increases over normal did not reach statistical significance. It is concluded that inflammation present in the nasal mucosa of asymptomatic asthmatics exhibits cellular characteristics also seen in endobronchial biopsies. This observation offers the possibility that mucosal biopsy may be an alternative and less invasive approach for studying the cells involved in the bronchial inflammatory reaction that possibly predisposes asthmatics to bronchial hyper-responsiveness.

Adolescent↗

PubMed1991

Expression of intercellular adhesion molecule 1 (ICAM-1) on human articular cartilage chondrocytes.

Monoclonal antibodies have been used to demonstrate the induction of intercellular adhesion molecule 1 (ICAM-1) on chondrocytes in human articular cartilage. ICAM-1 was found not to be constitutively expressed but could be induced by exogenous interleukin 1 alpha(IL1- alpha) at concentrations ranging from 0.01 to 20 ng/ml during in vitro culture. Maximum expression was observed with 2-5ng/ml. In time-course experiments ICAM-1 was not expressed after 4h in culture with IL1 alpha. Expression was induced by 16h and was sustained for a minimum of 6 days in the continued presence of the cytokine. The endothelial leukocyte adhesion molecule (ELAM-1) was not expressed on chondrocytes and was not induced by IL1-alpha.

Cartilage, Articular↗

PubMed1991

Parent-adolescent conflict and adolescent injuries.

Several studies have linked cumulative measures of stress to injuries, however none have examined the relationship between a prevalent stressor in adolescence, conflict between the parent and adolescent, and injuries. Data for this study came from 8231 British adolescents born one week in 1958 who had information on injuries between ages 15 and 17 available. A conflict scale was devised by summing mothers' assessments of the frequency of arguments with their 16-year-old offspring about eight problem areas. This scale had a linear association with injury rates for both boys and girls. Adolescent boys with high levels of conflict (greater than 90th percentile on conflict scale) had 2.9 times the rate of injuries resulting in hospitalization compared with boys from low conflict families (less than 25th percentile), and 1.6 times the number of injuries resulting in outpatient care. Girls with high levels of conflict had 2.9 times the hospitalized injuries and 1.8 times the rate of less severe injuries compared with girls with low conflict. These findings suggest that conflictual parent-adolescent relationships may be an indicator of increased injuries in adolescents.

Accidents↗

PubMed1990

Cytomegalovirus and Rasmussen's encephalitis.

In-situ hybridisation with a biotinylated cytomegalovirus (CMV) DNA probe was done on brain biopsy specimens from 10 patients with Rasmussen's encephalitis (RE) and 46 age-matched control patients with other neurological diseases. All 10 patients with RE had intractable epilepsy and focal neurological deficits, and there was perivascular cuffing, microglial nodules, astrogliosis, and neuronal loss. CMV genomic material was demonstrated in 7 of the 10 patients with RE (in neurons, astrocytes, oligodendrocytes, and endothelial cells) and in 2 of the 46 control patients. Probes for herpes simplex virus and hepatitis B virus were negative in all patients and in fibroblast controls. The results suggest that CMV is a likely cause of Rasmussen's encephalitis.

Adolescent↗

PubMed1990

Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen.

cDNA clones encoding CD31 have been isolated by transient expression. The sequence of CD31 expressed on human umbilical vein endothelial cells (HUVEC) is identical to that expressed on the monocyte-like cell line HL60. In HUVEC. CD31 is concentrated in regions of cell-cell contacts. CD31 is a member of the Ig superfamily and is most closely related to the carcinoembryonic antigen CEA, consisting of four contiguous C2 domains. The localization of CD31 to regions of cell-cell contacts, and the sequence similarity to CEA, a known intercellular adhesion molecule (ICAM), strongly suggest that CD31 may function as an ICAM, possibly mediating endothelial cell-cell contacts and also promoting interactions between leukocytes and endothelial cells.

Amino Acid Sequence↗

PubMed1990

Encephalopathy in liver transplantation: neuropathology and CMV infection.

The clinical histories and pathological findings of 27 autopsied cases of orthotopic liver transplantation (OLT) were reviewed. Fatal OLT was complicated in 93% of cases by neurological dysfunction, usually manifested by encephalopathy, with or without seizures. The etiology of the encephalopathy was largely multifactorial (44%) or undetermined (20%). Subarachnoid hemorrhage, central pontine myelinolysis, meningitis, brain infarction, polyclonal B cell lymphoma and spinal cord necrosis were common neuropathological findings. These diagnoses were often masked by other systemic illnesses. The role of cytomegalovirus (CMV) in neurologic dysfunction was explored with in situ hybridization and immunohistochemical techniques. OLT cases showed a significantly higher (89%) frequency of CMV genomic material in brain tissue compared to age-matched non immunocompromised (NIC) patients (23%). All OLT cases with encephalopathy of undetermined cause demonstrated usually prominent hybridization to the CMV probe. CMV may be an important cause of encephalopathy in such patients.

Adolescent↗

PubMed1990

Employment and drinking in early adulthood: a longitudinal perspective.

The relationship between drinking and employment was examined in a large, national representative longitudinal sample of young adults in Britain. Teenage drinking did not emerge as a strong influence upon subsequent employment experience: few associations were significant for either sex. However, early employment experiences did appear to be relevant to drinking in young adults, since unemployment of six months or more in total was significantly associated with heavier drinking in men (odds ratio = 1.38, CI 1.14-1.64). Respondents ratings of overall job satisfaction were not generally associated with either previous drinking or with that in early adulthood.

Adolescent↗

PubMed1990

The role of family formation and dissolution in shaping drinking behaviour in early adulthood.

The role of family formation and dissolution was examined in relation to alcohol consumption in early adulthood, using longitudinal data from a large representative British sample (the 1958 cohort). In comparison with other potential influences upon drinking, including employment and financial circumstances, social position and psychological wellbeing, the family formation patterns of young adults were most strongly associated with their current drinking. Stability and change in drinking between adolescence and early adulthood were also examined. Results were generally consistent with stable partnerships and family formation exerting a moderating influence on drinking since marriage and parenthood were most prevalent among groups reducing consumption or maintaining the lighter drinking of their teens. Most importantly, partnership breakdown was associated with heavier drinking established at age 16 and increasing consumption between adolescence and early adulthood.

Adolescent↗

PubMed1990

Childhood morbidity and adulthood ill health.

STUDY OBJECTIVE: The aim of the study was to investigate the relationship between the state of health in childhood and ill health in early adult life. DESIGN: The study used data collected as part of the National Child Development Study and related health at 7 years of age to that at 23. A wide range of information on child health in the cohort was available, which was used to construct a broader measure of health status than selected diagnostic categories. SETTING: The survey population was nationwide. PARTICIPANTS: The study population included all children born in the week 3-9 March 1958. They were followed up at 7, 11, 16, and 23 years. Of the target population of 17,733 births, 12,537 (76%) were retraced and interviewed at 23. MEASUREMENTS AND MAIN RESULTS: Children at age 7 were allocated to 13 morbidity groups; 20% of children had reported no ill-health apart from the common infectious diseases, but 10% were included in four or more of the morbidity groups. Children with no reported morbidity retained their health advantage into early adulthood: ratios of observed to expected ill health for four of the five indices examined at age 23 were all significantly below one (self rated health 0.81, asthma and/or wheezy bronchitis 0.63, allergies 0.79, emotional health 0.75). Children with more morbidity at age 7 had higher ratios of ill health in adulthood. A chronic condition in childhood was associated not only with excess morbidity in the short term but also with a poor health rating in early adult life (ratio = 1.38). Morbidity was significantly increased for most of the adulthood indices among children with asthma and/or wheezy bronchitis. However most ill health in young adulthood occurred in study members with a relatively healthy childhood. CONCLUSIONS: Although the state of health in childhood has long term implications, it does not form a substantial contribution to ill health in early adult life.

Acute Disease↗