Biomedical subjects
C Preponis
Publications and source records attributed to C Preponis.
Intraparotid facial nerve neurilemmoma: a case report.
A case report of intraparotid facial nerve neurilemmoma is presented. The survey of this pathology is reviewed.
Tracheotomy in neonates.
The particularities and complications of tracheotomy in neonates, as well as postoperative care and follow-up are presented. During the five year period from 1991-1996, 12 urgent tracheotomies were performed on 12 neonates in the Hippokration Hospital of Thessaloniki, 7 boys and 5 girls, ranging from 1 to 25 days. All these infants presented severe respiratory failure due to upper airway obstruction. Endotracheal intubation was attempted on all of them with no success, and urgent tracheotomy was recommended by the neonatologists. Three out of the twelve neonates died (the first during the procedure, the second just after the procedure and the third one week later) while the remaining nine were relieved from respiratory distress. Tracheotomy is a procedure of major importance for the survival and further development of young patients.
The effect of loratadine on activated cells of the nasal mucosa in patients with allergic rhinitis.
The effect of loratadine on the numbers of activated cells--cells expressing interleukin-2 receptors(IL-2R), HLA-DR antigens and proliferating cell nuclear antigen (PCNA)--in the nasal mucosa was studied in 48 patients with allergic rhinitis. Patients were treated with either loratadine (10 mg) or placebo for 1 month. At the end of treatment, a significant decrease in the symptom scores was noted in both groups of patients. However, the clinical score was significantly lower in the loratadine group compared to the placebo group. At the end of treatment, the numbers of IL-2R+, HLA-DR+ and PCNA+ cells were significantly decreased only in the group on loratadine. An almost significant correlation was also observed between the numbers of IL-2R+ cells and symptoms in the loratadine group. Our results show that loratadine exerts its beneficial effect possibly by inhibiting both the action of histamine and immune activation.