Biomedical subjects

C R Beamon

Publications and source records attributed to C R Beamon.

3 recordsLinked to original sources

PubMed1978

Effect of obstruction of renal metabolism. Renal tissue metabolite concentration after alpha-ketoglutarate infusion.

beta-Hydroxybutyrate and/or alpha-ketoglutarate were infused into awake, resing dogs after varying periods of unilateral ureteral obstruction. The animals were then anesthetized, and the kidneys rapidly excised and frozen in liquid nitrogen. While maintained at temperatures below -60 C, the frozen kidneys were separated into cortical and medullary fractions. The concentrations of alpha-ketoglutarate, glutamate, lactate, pyruvate, citrate, and malate were determined in both cortical and medullary renal tissue. The induction of reversible renal damage by 2 weeks of obstruction was associated with decreased ability to accumulate alpha-ketoglutarate after alpha-ketoglutarate and/or beta-hydroxybutyrate infusion. The induction of irreversible renal damage by 6 weeks of obstruction was associated with the inability to produce or accumulate (i) alpha-ketoglutarate, (ii) lactate, (iii) citrate, or (iv) malate after infusion of alpha-ketoglutarate and/or beta-hydroxybutyrate. The metabolic changes induced by unilateral ureteral obstruction indicatr that aerobic metabolism is inhibited with the virtual elimination of many aerobic reacions in the irreversibly damaged kidney. The reversibly damaged kidney is capable carrying on certain aerobic reactions but usually at a diminished rate. Differences in the extent and character of the metabolic changes induced by ureteral obstruction may make it possible to predict the degree of renal damage and, therefore, recoverability.

Aerobiosis↗

PubMed1977

Effects of ureteral obstruction on the renal metabolism of alpha-ketoglutarate and other substrates in vivo.

The renal metabolims of alpha-ketoglutarate, glutamate, oxygen, carbon dioxide, and citrate during the infusion of beta-hydroxybutyrate and/or alpha-ketoglutarate was evaluated in vivo in the awake, resting dog after varying periods of unilateral ureteral obstruction. The induction of reversible renal damage by 2 weeks of obstruction was associated with (i) decreased utilization of alpha-ketoglutarate and oxygen; (ii) decreased production of carbon dioxide; (iii) elevated respiratory quotient; and (iv) nearly complete lack of citrate production. The induction of irreversible renal damage by 6 weeks of obstruction was associated with (i) a nearly total absence of alpha-ketoglutarate utilization; (ii) a markedly decreased amount of oxygen utilization and carbon dioxide production; (iii) a normal respiratory quotient; and (iv) a nearly total absence of citrate production. The metabolic changes observed after obstruction indicate that aerobic metabolism is inhibited by either reversible or irreversible renal damage. However, certain anaerobic reactions continued in the reversibly damaged kidney. Differences in the extent and character of metabolic changes may make it possible to predict the degree of renal damage.

Anaerobiosis↗

PubMed1976

Two rare cases of ectopic testis.

A case of pubopenile testis and a case of perineal ectopic testis are presented. The mechanism of descensus is largely positive, possibly facilitated by raised intra-abdominal pressure. The testis is usually guided by the gubernaculum and ectopia results from gubernacular failure. The ectopic testis is relatively rare but is easily recognized and treated by orchiopexy.

Child, Preschool↗