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Biomedical subjects

C R García

Publications and source records attributed to C R García.

At least 19 recordsLinked to original sources

Management of the symptomatic fibroid in women older than 40 years of age. Hysterectomy or myomectomy?

Although complications resulting from a myomectomy are infrequent, the overall risk is probably greater than a hysterectomy. The effect of hysterectomy on the specific women is difficult to quantify, however. Supracervical hysterectomy is a reasonable alternative in the woman with a normal cervix. Moreover, repeated laparotomies are not particularly advisable. In a woman who has previously undergone a myomectomy and has had a recurrent symptomatic myomatous uterus, the decision must be made either to proceed with a repeat myomectomy or to perform a hysterectomy. The chance of successfully achieving a pregnancy after a second myomectomy may be less favorable than after a primary myomectomy. A myomectomy can be a difficult and often time-consuming procedure. With meticulous attention to technique, however, the procedure can be accomplished safely and effectively with relatively ensured hemostasis and minimal blood loss. A myomectomy affords the option of preserving the uterus in those patients with symptomatic uterine myomata who desire to preserve their reproductive organs. However, careful assessment with meticulous counseling of the patient is essential. The potential option for a hysterectomy must always be preserved. Hysteroscopic resection of submucous myomata with endometrial ablation has become the technique of preference in many cases. At the moment, abdominal myomectomy is the preferred technique for the removal of intramural and subserosal myomata. For the present, laparoscopic myomectomy must be viewed as being of very limited acceptability.

Female↗

Perioperative complications arising after transvaginal oocyte retrieval.

OBJECTIVE: To determine the incidence of perioperative morbidity in patients undergoing transvaginal oocyte retrieval and to identify those patients at greatest risk for complications. METHODS: A retrospective analysis was performed on 674 patients of reproductive age who underwent transvaginal retrieval of oocytes for assisted reproduction technologies during a 3-year period. All procedures were performed by surgeons with extensive experience with transvaginal retrieval. Patients were entered into the program with a primary diagnosis of unexplained infertility (16%), endometriosis (32%), pelvic adhesions and/or tubal occlusion (38%), or infertility from male or immunologic factors (14%). RESULTS: Of the 674 patients studied, ten (1.5%) required hospital admission because of perioperative complications. Nine of these patients needed intravenous antibiotics and one required admission and observation for an expanding broad-ligament hematoma. Six of nine women admitted for antibiotic therapy had a history of extensive pelvic adhesions with or without a history of salpingitis. Five of nine patients had a history of salpingitis. In addition, two patients experienced impressive vaginal arterial bleeding during the procedure. CONCLUSION: This study suggests that transvaginal retrieval may not be as innocuous as is often expressed and that the primary factor predisposing to perioperative morbidity is a history of previous pelvic inflammatory disease and/or adnexal adhesions.

Adult↗

Ovarian function after conservational ovarian surgery: a long-term follow-up study.

OBJECTIVE: To determine the long-term effects of conservational ovarian surgery on subsequent ovarian function. METHOD: Medical, surgical and menstrual records of 87 reproductive age women who have undergone pelvic surgery for indications including endometriosis, infertility, and pelvic pain between June 1982 and June 1989 were retrospectively reviewed. RESULTS: Sixty-seven patients had ovarian surgery during their procedure; 26 ovarian cystectomies (OC), 19 partial ovarian resections (OR) and 22 ovariolyses (OL). Twenty patients had no ovarian surgery (NOS). The mean follow-up period was comparable in all groups (OL 32 +/- 15 months, OR 34 +/- 26 months, OC 41 +/- 30 months and NOS 37 +/- 21 months). The mean time to onset of the first postoperative menses was not significantly different among the four groups (OL 24 +/- 7 days, OR 24 +/- 13 days, OC 29 +/- 26 days and NOS 22 +/- 6 days). The cumulative conception rates were not significantly different (OL 23%, OR 37%, OC 19% and NOS 25%). Menstrual disturbances, defined as perceived deviations from preoperative patterns, did not appear to be related to the type or extent of ovarian surgery and occurred in comparable frequencies among patients with or without ovarian surgery (OL 23%, OR 37%, OC 23% and NOS 20%). In the majority of cases, menstrual disturbances occurred either in the early postoperative months and were self-limited, or much later in which case they were related to recurrent endometriosis. Premature ovarian failure has so far occurred in one patient suggesting an incidence comparable to that in the general population. CONCLUSIONS: It is concluded that in this group of patients, conservational ovarian surgery had no significant effects on ovulatory and menstrual function over a prolonged follow-up period.

Adolescent↗

Uterine müllerian adenosarcoma with histiocytic (xanthomatous) mesenchymal component.

We present an endometrial Müllerian adenosarcoma in which the sarcomatous component showed prominent nests of foamy cells that accounted for 50% of the neoplastic mesenchyma. Such foamy cells showed occasional cytological atypias and immunohistochemical features of histiocytic (macrophagic differentiation in the absence of changes that could substantiate the presence of an inflammatory infiltration of foamy histiocytes. These facts suggest histiocytic differentiation from neoplastic mesenchymal cells. Such differentiation has been reported in association with malignant mixed mesodermal tumor, but not in Müllerian adenosarcoma.

Biomarkers, Tumor↗

Preservation of the ovary: a reevaluation.

The incidence of routine ovariectomy approximates 20% to 30% of all women at hysterectomy. The propriety of this practice is evaluated from three perspectives: the review of the longevity of ovarian hormonal function throughout life, the review of the low risk of subsequent disease in the retained ovary, and the review of epidemiologic considerations. Because oophorectomy and the loss of its steroid contribution has such a profound influence on many body functions, with the most devastating relation to osteoporosis, and because there are no meaningful data in the literature to support the value of routine oophorectomy, removal of ovaries should only be performed when the ovaries are diseased.

Adult↗

Emotional distress in morning-after pill patients.

The self-administered SCL-90 test was utilized to collect emotional distress data on 120 female patients requesting morning-after pill pregnancy interception. SCL prescores were significant in anxiety, guilt and depression factors. The 2-week post-treatment results showed a significant decrease in these factors. This test provides reliable measurement of emotional distress factors in gynecologic GYN patients. The results must be considered supportive for the use of DES interceptive therapy in spite of other clinical considerations relative to its safety.

Affective Symptoms↗

Pelvic endometriosis: infertility and pelvic pain.

A multifactorial approach was used by the authors to analyze data from 119 women with endometriosis and infertility. Conservative surgical procedures afforded a mean pregnancy rate of 37.7 per cent for those women with significant disease. Only 6.7 per cent became pregnant when the proposed surgery was declined. There was an inverse relationship in severity of endometriotic involvement and pregnancy rate. The mean pregnancy rate among 17 patients with minimal disease for whom surgery was discouraged was 64.7 per cent; all pregnancies occurred within the first 2 years of follow-up. Relief of pelvic pain was dramatic, especially following presacral neurectomy. Laparoscopic selection of cases further reinforces the importance of grading severity of endometriosis prior to embarking on restorative surgery. Presacral neurectomy, despite reinforcement of pain relief, did not appear to contribute significantly to the occurrence of pregnancy.

Adult↗