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Biomedical subjects

C R Huxtable

Publications and source records attributed to C R Huxtable.

At least 55 records · Page 3Linked to original sources
PubMed1980

Canine parvoviral myocarditis: a morphologic description of the natural disease.

Naturally occurring acute parvoviral myocarditis in puppies 3 to 8 weeks of age was characterised clinically by sudden death or death following a brief period of dyspnoea. Mortality within litters varied from 20% to 100%. The principal lesion was in the myocardium, which in most cases was mottled by pale patches and bands. Moderate to severe pulmonary oedema with marked peribronchial and perivascular oedema was present. In some cases, the wall of the gall bladder was oedematous. Microscopically the ventricular myocardium had myofibre loss, multifocal myofibre necrosis, a mononuclear cell infiltrate of variable intensity and reactive stromal elements. In every case there were Feulgen-positive, amphophilic, and reactive stromal elements. In every case there were Feulgen-positive, amphophilic, intranuclear inclusion bodies in myocardial nuclei. Ultrastructurally the inclusions were composed of dense granular material and particles resembling parvovirions. Pulmonary alveolar septae were thickened by fibroblasts. Peribronchial and perivascular lymphatics were distended with oedema fluid and occasionally erythrocytes. The pulmonary lesions were considered secondary to the myocardial dysfunction. Some of the puppies that survived the acute disease developed ventricular myocardial fibrosis and died in congestive heart failure.

Animals↗
PubMed1980

Canine laryngeal oncocytomas.

Solitary, protruding tumors were found in the wall of the larynx in three adult dogs with clinical upper respiratory obstruction. They were composed of cells with abundant granular acidophilic cytoplasm, the granularity caused by an unusually large number of mitochondria. The lesions were considered to be neoplasms arising from oncocytes as described in man. Oncocytomas have not been reported previously in domestic animals.

Adenoma↗
PubMed1979

Placental lesions in habitually aborting cats.

An ovariohysterectomy was done on five female cats with a history of habitual abortion in the 3rd to 4th week of pregnancy and the foetuses and placentas examined. Histologic and electron microscopic examination showed multifocal placental necrosis which was deduced to begin in the syncytial trophoblastic cells and to extend to all the cells of the labyrinth. This lesion was followed by foetal autolysis. No bacterial, viral or mycoplasmal agents could be incriminated in the disease.

Abortion, Habitual↗
PubMed1979

Clinical and electrocardiographic findings in suspected viral myocarditis of pups.

Surviving puppies from three separate litters in which deaths had occurred from suspected viral myocarditis were examined clinically and electrocardiographically. Of 11 puppies examined, 5 subsequently died or were euthanised within 11 days of initial examination. ECG changes present in these puppies for 1 to 11 days prior to death were small R waves (less than 0.4 mV in lead II), S-T segment elevation, QRS notching and paroxysmal ventricular tachycardia (PVT). No clinical signs referable to the ECG changes were present before the terminal episodes of apparent sudden death or death following a brief period of dyspnoea. Multifocial subacute myocarditis was present on post-mortem examination. A sixth puppy with small R waves remained clinically normal for a further 4 weeks. It then developed severe dyspnoea which persisted for 24 hours before euthanasia. Extensive fibrosis of the left ventricle was present on post-mortem examination.

Animals↗
PubMed1976

Paraquat poisoning in a dog and cat.

Paraquat (1,1'-dimethyl-4,4'-bipyridylium dichloride) has in the last decade gained popularity as an effective weedicide. It is marketed for commercial use as a liquid concentrate Gramoxone ICI (20% paraquat). Accidental or intentional ingestion of Gramoxone has caused 232 human deaths between 1964 and 1973 (Anon 1974). Most human patients suffer transient renal and hepatic insufficiency and pulmonary oedema followed after a latent period by progressive pulmonary fibrosis leading to death from respiratory failure (Harrison 1972). The clinical features of non-fatal paraquet poisoning in a cat and the clinical and pathological findings in fatal poisoning in a dog are reported.

Animals↗
PubMed1976

Basophil leucocytes in cutaneous hypersensitivity reactions in nematode-infected guinea-pigs.

Cutaneous hypersensitivity reactions were elicited in guinea-pigs infected with the parasitic nematode Trichostrongylus colubriformis by injecting them with a crude extract of T. colubriformis fourth-stage larvae. The reaction was characterized by early oedema and pronounced cellular infiltration, initially with neutrophils but later with mononuclear cells, basophils and variable numbers of eosinophils. Because basophils have been implicated as effector cells in the protective immune response of guinea-pigs to this nematode, the capacity to elicit a basophil-rich cellular infiltrate in infected animals might be a useful assay for T. colubriformis protective antigen(s).

Animals↗
PubMed1975

Studies of the responses of basophil and eosinophil leucocytes and mast cells to the nematode Trichostrongylus colubriformis. Ultrastructural changes in basophils and eosinophils at the site of infection.

Basophil and eosinophil leucocytes infiltrate the small intestinal lamina propria of guinea-pigs infected with the nematode Trichostrongylus colubriformis. By comparing the morphology of both cell types at the site of infection with bone marrow and buffy coat cells, it was found that, after entering the lamina propria, basophils developed an electron lucent halo beneath the granule-limiting membrane while the characteristic orderly periodicity of the granules changed to a fibrillar or amorphous appearance. The granules also tended to coalesce but remained within the cell. Approximately half the eosinophils at the site of infection developed deficiencies in the amorphous outer matrix of their granules but showed no obvious change in the central electron-dense cores.

Animals↗