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Biomedical subjects

C R Kirk

Publications and source records attributed to C R Kirk.

14 recordsLinked to original sources

Medication errors in paediatric practice: insights from a continuous quality improvement approach.

UNLABELLED: The objective was to assess the incidence and consequences of medication errors, highlight sources of recurrent error and institute changes in practice to prevent their recurrence. Utilising a continuous quality improvement approach, a 2-year prospective cohort study was undertaken using an adverse incident reporting scheme. A multidisciplinary committee analysed medication error reports, classifying them according to type (prescription, supply or administration), severity (serious or not serious) and clinical outcome. Changes in policy and practice were implemented to reduce the frequency of errors. There were 441 reported medication errors in the study period, during which 682 patients were admitted for 5315 inpatient days. Errors were more seven times likely to occur in the intensive care setting. Doctors accounted for 72% of errors and prescription errors doubled when new doctors joined the rotation. Most errors (68%) were detected prior to drug administration. Twenty-four serious medication errors were not detected in advance, but only 4 had overt clinical consequences. Excluding prevented errors and appropriate deviations from prescribed therapy, there were 117 actual medication errors (1/5.8 admissions, or 1/45 inpatient days). During the 2nd year of the scheme, the incidence of all reported errors, administration errors and serious errors fell, but the prescription error rate remained constant. CONCLUSIONS: Medication errors occurred commonly in this study, but adverse consequences were rare. The non-punitive, multidisciplinary approach to medication errors utilised in this study increased staff vigilance, highlighted sources of recurrent error, and led to changes in drug policies and staff training, which resulted in improved patient safety and quality of care.

Cohort Studies↗

Absent pulmonary valve syndrome with interrupted aortic arch.

A surgically treated case of absent pulmonary valve syndrome associated with type B interrupted aortic arch is presented. The presence of a restrictive ductus arteriosus promoted the development of a collateral circulation between ascending and descending thoracic aorta, allowing the child to remain clinically stable after birth.

Aorta, Thoracic↗

Streptokinase in the management of arterial thrombosis in infancy.

Fourteen children with a mean age of 9.7 months (range 0.1-34.0 months) and a mean weight of 5.4 kg (range 2.5-10.0 kg) received intravenous streptokinase following arterial thrombosis. A median loading dose of 1000 U/kg (range 750-4000 U/kg) was given followed by an initial median infusion rate of 1000 U/kg/hr (range 750-1000 U/kg/hr). If thrombolysis did not occur and the fibrinogen level remained within the normal range (1.5-4.5 g/l) the infusion rate was increased to a maximum of 3000 U/kg/hr. Thrombolysis was achieved in all cases a mean of 16.7 hours (range 2-44 hours) after the start of treatment. The mean fibrinogen level at thrombolysis was 1.11 g/l (range 0.28-2.25 g/l) compared with pretreatment levels of 2.12 g/l (range 1.4-3.05 g/l). Minor bleeding from arterial puncture sites occurred in 6 children (43%). Streptokinase is a safe and effective treatment for arterial thrombosis in children.

Arterial Occlusive Diseases↗

Streptokinase for aortic thrombosis.

A neonate developed complete thrombosis of the abdominal aorta after catheterisation of the umbilical artery. This was successfully treated with an intravenous infusion of streptokinase.

Aorta, Abdominal↗

Protein-losing enteropathy caused by baffle obstruction after Mustard's operation.

Three patients developed protein-losing enteropathy caused by intra-atrial obstruction of the systemic venous return after Mustard's operation. The enteropathy resolved in one case after reoperation and in the others after balloon dilatation of the stenosed caval pathways. Protein-losing enteropathy may occur as a complication of Mustard's operation. Balloon dilatation of the obstructed baffle is an effective alternative to reoperation.

Humans↗

Balloon dilatation of the pulmonary valve in the first year of life in patients with tetralogy of Fallot: a preliminary study.

Fifteen infants with tetralogy of Fallot, who would otherwise have required a palliative operation, underwent balloon dilatation of the right ventricular outflow tract. The mean period of palliation was 8.5 months (range 0-26 months). The procedure was performed without serious complications on 88% of occasions. This preliminary study suggests that balloon dilatation may be useful in the management of tetralogy of Fallot.

Catheterization↗

The diabetic with a diabetic parent.

Six of eight children with diabetes who have a parent with type I diabetes mellitus presented serious management problems. The doctor and diabetic health visitor should be aware that these families may require extra support.

Adolescent↗