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Biomedical subjects

C R Lee

Publications and source records attributed to C R Lee.

11 recordsLinked to original sources
PubMed1979

Inexpensive analog equipment for processing gas chromatography mass spectrometry data.

Using relatively simple analog circuitry, and an inexpensive analog frequency modulated tape recorder (or a modified audio recorder) for data storage, repetitively scanned spectra may be examined on an oscilloscope, and reconstructed mass chromatograms produced. The same equipment may be used for peak matching, and for selective ion detection over the full mass range of a sector instrument.

Chromatography, Gas↗
PubMed1979

Urinary dicarboxylic acids in patients receiving lithium or rubidium salts.

Lithium salts administered in therapeutic doses to four subjects who were kept on controlled diets increased up to fivefold the urinary output of some dicarboxylic acids. Some of the acids affected are intermediates in the tricarboxylic acid cycle, others are chemically similar but not directly related in metabolic terms. This is probably a direct effect on renal transport. Rubidium salts increased urinary 2-oxoglutarate output and blood 2-oxoglutarate levels, probably by some action on intermediary metabolism.

Bipolar Disorder↗
PubMed1978

Effects of rubidium chloride on the course of manic-depressive illness.

Clinical studies of the effects of rubidium ions on the course of manic-depressive illness are reported. It seems that rubidium tends to increase the length of manic phases and possibly reduces the extremes of mood. Rubidium did not seem to produce any severe side effects in the dose administered, but it has a long biological half-life and caution is still required. Some details of the CSF, RBC, saliva and plasma and urine kinetics are also reported.

Adult↗
PubMed1977

Lithium.

Explore the source record for details and available documents.

Erythrocytes↗
PubMed1976

Determination of urinary monohydric and dihydric phenols by gas chromatography of the acetate and TMS derivatives. 4-Dimethylaminopyridine as a catalyst for acetylation reactions.

A procedure is described for the quantitative extraction of phenols from human urine. The compounds were chromatographed as the trimethylsilyl derivatives on wall-coated glass capillary columns. A more specific method of extraction involving the formation of acetate derivatives is also described. The acetates were prepared by treating dilute solutions of phenols at room temperature with acetic anhydride in the presence of 4-dimethylaminopyridine, which is a far more powerful catalyst than pyridine. Under these conditions N-acylamino acids are converted to azlactones.

4-Aminopyridine↗