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C R Legg

Publications and source records attributed to C R Legg.

18 recordsLinked to original sources
PubMed1995

Is there a visual deficit in dyslexia resulting from a lesion of the right posterior parietal lobe?

Dyslexia has conventionally been attributed to a left hemisphere deficit affecting language skills. However, it has recently been suggested that two-thirds of dyslexic people have a lesion of the right posterior parietal lobe (RPPL) resulting in poor oculo-motor control. It has been reported that neurological patients with RPPL lesions commonly manifest a neglect of the left side of space and this has also been described in clinical observations of 'visual dyslexics'. We investigated this hypothesis with a sample of 53 dyslexic children and 53 controls using a line-bisection task. In the horizontal test condition both groups tended to transect slightly to the left of the midpoint (mean displacement 0.14 mm for controls; 0.4 mm for dyslexics). The result suggests a small right side neglect which, contrary to one report in the literature, is found here in developmental dyslexics as well as controls, and leads to the conclusion that RPPL lesion is unlikely to be a common feature of dyslexia.

Adolescent↗
PubMed1992

Cerebellar connections of the ventral lateral geniculate nucleus in the rat.

The connections between the deep cerebellar nuclei and the ventral lateral geniculate nucleus (LGv) were investigated in rats using orthograde and retrograde transport of horseradish peroxidase. Following injections into the deep cerebellar nuclei there was orthograde transport to the contralateral medial LGv and adjacent zona incerta. Injections restricted to LGv consistently labelled a small cluster of cells in the contralateral posterior interposed nucleus. Injections into regions surrounding LGv produced distinctively different patterns of orthograde and retrograde labelling.

Animals↗
PubMed1990

Distance estimation in the hooded rat: experimental evidence for the role of motion cues.

The role of motion cues, generated by vertical head movements, in distance estimation by hooded rats was investigated in a jumping task in which animals were trained to jump randomly varying gaps between two elevated platforms. In the first experiment it was shown that the disposition of texture cues influenced the number of head movements made prior to jumping, showing that the movements are related to visual aspects of the task. In the second experiment it was shown that stroboscopic illumination disrupted accurate jumping but animals could jump accurately to a platform when only the leading edge was visible, showing that they depend on motion cues but not motion parallax.

Animals↗
PubMed1990

Basal ganglia and cerebellum receive different somatosensory information in rats.

There are two great subcortical circuits that relay sensory information to motor structures in the mammalian brain. One pathway relays via the pontine nuclei and cerebellum, and the other relays by way of the basal ganglia. We studied the cells of origin of these two major pathways from the posteromedial barrel subfield of rats, a distinct region of the somatosensory cortex that contains the sensory representation of the large whiskers. We injected tracer substances into the caudate putamen or the pontine nuclei and charted the location of retrogradely filled cortical cells. In preliminary studies, we used double-labeling techniques to determine whether the cells of origin of these two pathways send axon collaterals to other subcortical targets. Lamina V of the rat posteromedial barrel subfield contains two distinct populations of subcortically projecting neurons, which are organized into distinct sublamina. . Corticopontine cells are located exclusively in sublamina Vb, the deeper of two sublamina revealed by cytochrome oxidase staining. Corticostriate cells are located almost exclusively in the more superficial sublamina Va. Experiments using double-labeling fluorescent tracers demonstrate that about one-quarter of the corticopontine cells send a collateral branch to the superior colliculus. Other studies have shown that cells in Vb are activated at very short latency after vibrissal stimulation; hence, they would seem to be an appropriate relay for the rapid transmission of sensory information to the cerebellum for use in sensory guidance of movement.

Animals↗
PubMed1989

Corticopontine projection in the rat: the distribution of labelled cortical cells after large injections of horseradish peroxidase in the pontine nuclei.

The distribution of cortical cells projecting to the pontine nuclei in rats was studied by making large injections of horseradish peroxidase that filled the basilar pons and measuring the density of labelled cells in each cortical area. All retrogradely labelled cells were layer V pyramidal cells. The highest densities of labelled cells were observed in the motor areas. The lowest densities were in temporal association cortex and perirhinal cortex. Visual cortical areas, including the primary visual cortex, provided a major source of pontine projections. The distribution of corticopontine cells within the primary visual cortex was studied in more detail. In all cases the highest density of labelled cells was observed in the region of cortex that represents the nasal visual field. Control injections into brainstem regions adjacent to the pontine nuclei produced a much lower absolute density of retrogradely labelled cortical cells and the distribution of those cells was different from that observed following pontine injections. We conclude that every area of the rat's cerebral cortex projects to the pontine nuclei and that there are consistent variations in the density of the projections both between and within areas.

Animals↗
PubMed1988

The pretectum and visual discrimination learning in the hooded rat.

In previous studies on the effects of pretectal lesions on visual discrimination performance, the lesions have either been small or their effects confounded with damage to the adjacent thalamus and the results have been inconsistent. This study compares the effects of large pretectal lesions (PRT) with lesions in lateral (TLP) and medial (MPT) posterior thalamus on simultaneous black versus white (BW), horizontal versus vertical (HV) discrimination acquisition and low frequency flicker detection. An unoperated control group treated regularly with a cycloplegic to produce mydriasis was also tested in the discrimination learning phase. PRT lesions and treatment with the cycloplegic produced mydriasis as well as an impairment on BW. Neither group was impaired on HV. Animals with MPT and TLP lesions were impaired on BW and HV and those with TLP lesions were also impaired on flicker detection. It is concluded that the pretectum is important for visual intensity discrimination learning but the effects of lesions are due to disturbances of pupillary control. The significance of this finding for the interpretation of deficits produced by lesions elsewhere in the thalamus is discussed.

Animals↗
PubMed1986

Spatial contrast and flicker sensitivity following medial thalamic or visual cortex lesions in hooded rats.

In rats, lesions of the medial thalamus that involve the intralaminar nuclei produce a number of visual impairments similar to those obtained with visual cortex ablation, suggesting that the former functionally disrupt visual cortex. This was tested by a direct comparison between the two lesions on spatial contrast and flicker sensitivity, using behavioural techniques. Both lesions depressed spatial contrast sensitivity, visual cortex damage more than thalamic lesions. Only medial thalamic lesions produced statistically significant changes in flicker sensitivity. This dissociation suggests that medial thalamic and visual cortex lesions are disrupting different mechanisms. Alternative explanations of the thalamic deficit are discussed.

Animals↗
PubMed1984

Contrast sensitivity at low spatial frequencies in the hooded rat.

Behavioural methods were used to measure spatial contrast sensitivity, to vertical sine-wave luminance profile gratings, in hooded rats. Low frequency attenuation of sensitivity was observed at spatial frequencies below 0.1c/deg. This attenuation exceeded that produced by varying the number of periods in the grating, indicating that it was a function of spatial frequency as well as number of periods.

Animals↗
PubMed1983

Flicker sensitivity changes after subcortical visual system lesions in the rat.

Sensitivity to sinusoidal flicker, as a function of flicker frequency, was measured behaviourally in hooded rats by reducing modulation depth in a two-choice flicker versus no-flicker discrimination until subjects could not perform at above 80% correct. Analogous methods were used to measure spatial contrast sensitivity. In both tasks the display area was 24 x 20 degrees. Bilateral lesions were made in one of 4 structures; superior colliculus (SC), pretectum (PRT), posterior thalamus (PT), or ventral lateral geniculate nucleus (LGv). A fifth group served as sham operated controls. On the basis of histology the LGv group was subdivided according to presence or absence of optic tract damage. PT, PRT and LGv lesions produced a statistically significant depression in flicker sensitivity, the impairment in the LGv sub-group with optic tract damage being significantly greater than that in the LGv group with optic tract sparing. In the latter, post-operative sensitivity correlated significantly with amount of surviving tissue in the thalamic radiations but not with surviving LGv itself. PRT and LGv lesions that involved the optic tract also significantly depressed spatial contract sensitivity. The implications of the finding, that PT and LGv lesions may depress flicker sensitivity without affecting spatial vision, for interpretation of the effects of comparable lesions on suprathreshold discrimination are discussed.

Animals↗
PubMed1983

Spatial contrast sensitivity changes after subcortical visual system lesions in the rat.

Spatial contrast sensitivity functions were determined in hooded rats after lesions involving the pretectum (PRT), rostral pretectum and adjacent medial thalamus (PRT +), posterior thalamus (PT), or ventral lateral geniculate nucleus (LGv). PRT and PRT + lesions depressed sensitivity at both high and low spatial frequencies but the high frequency loss was much greater in the latter group. PT lesions depressed sensitivity to frequencies of 0.45 cycles/deg. and above but had no detectable effect upon low frequencies while LGv lesions depressed sensitivity to both high and low frequencies. The discussion relates these results to previous reports of discrimination learning impairments after comparable lesions.

Animals↗
PubMed1982

The contribution of the corpus callosum to receptive fields in the lateral suprasylvian visual areas of the cat.

In both ordinary cats and 'Boston' Siamese cats the visual areas in the lateral parts of the middle and posterior suprasylvian gyri (LSA) contain an extensive representation of the ipsilateral half of the visual field. In addition, in both groups of cats the overwhelming majority of neurons in LSA can be driven from both eyes. In Siamese cats this binocular interaction is in marked contrast with what is found in area 17 where neurons are almost exclusively activated through the contralateral eye. Transection of the posterior 1/3 to 1/2 of the corpus callosum had a different effect on the physiological organization of LSA in the two types of cats. In ordinary cats it caused the loss of the ipsilateral hemifield representation in the eye ipsilateral to the side of recording and reduced this representation in the other eye. However, after the section of the corpus callosum LSA neurons remained binocular. In Siamese cats the callosal transection left the representation of the ipsilateral hemifield in LSA unaffected, both totally abolished the input from the ipsilateral eye. These findings suggest that the visual callosal input to LSA has a different functional significance in ordinary and Siamese cats. In the former cats it may be related to perceptual equivalence across the vertical meridian of the visual field, whereas in the latter cats it may subserve interocular equivalence.

Animals↗
PubMed1979

Visual discrimination impairments after lesions in zona incerta or lateral terminal nucleus of accessory optic tract.

Possible visual functions of zona incerta (ZI) and lateral terminal nucleus of the accessory optic tract (LTN) in rats were investigated by comparing the effects of localized lesions on a series of discrimination learning tasks. In Experiment 1 animals with ZI lesions were impaired on a simultaneous black versus white (BW) discrimination but not on a simultaneous horizontal versus vertical (HV) task. Animals with LTN lesions were impaired on HV but not on BW. Rats with ZI lesions were impaired on a successive bright versus dim but not a successive HV discrimination when subsequently tested in Experiment 2. Animals with LTN lesions were impaired on both tasks. The results are related to the possibility that visual intensity information gains access to the motor system through a pathway running from the ventral lateral geniculate nucleus to the basal ganglia via ZI. Since LTN lesions impaired acquisition of a HV discrimination, a task highly susceptible to the effects of geniculostriate ablation, it is suggested that such lesions impair the use of visual information without distroying the sensory channels mediating the discrimination.

Animals↗
PubMed1977

The role of the ventral lateral geniculate nucleus and posterior thalamus in intensity discrimination in rats.

The role of several subcortical structures in intensity discrimination was studies by examining the effects of localized lesions on intensity and orientation discrimination. In experiment 1 rats with lesions confined to the ventral lateral geniculate nucleus (LGNv) or posterior thalamus were specifically impaired on postoperative acquisition of the intensity discrimination compared with sham operated controls or rats with destruction of the superior colliculi. The lesions had no effect on the orientation discrimination unless the primary visual pathways were also damaged. The effects of LGNv damage on intensity discrimination were confirmed with much smaller lesions in experiment 2. In experiment 3 it was shown that postoperative retention of the intensity discrimination is also specifically impaired by destruction of LGNv. The results are related to the possiblility that information about intensity and pattern is coded in separate visual pathways.

Animals↗
PubMed1977

Effects of subcortical lesions on visual intensity discriminations in rats.

The role of several subcortical structures in visual intensity discrimination was examined by comparing the effects of localized lesions on a variety of intensity discriminations. In Experiment 1 light avoidance was unimpaired after lesions of the ventral lateral geniculate nucleus (LGNv), nucleus lateralis posterior (TLP), nucleus posterior of Gurdijian (NPG), dorsal pretectum (PTd), and ventral pretectum (PTv). The LGNv, TLP, NPG and PTv, but not the PTd, groups were impaired on a simultaneous black versus white (BW) discrimination in Experiment 2. None of these groups was impaired on a horizontal versus vertical discrimination (HV). The TLP group showed a transient impairment on a successive light versus dark discrimination, not present with the LGNv and NPG groups (Experiment 3). In Experiment 4 all three groups were impaired on a successive BW discrimination. In Experiment 5 rats with LGNv lesions but not with TLP lesions had elevated relative brightness thresholds. Both groups had normal absolute thresholds. The results are related to the possibility that information about intensity and pattern is coded in separate visual pathways.

Animals↗