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Biomedical subjects

C R Lo

Publications and source records attributed to C R Lo.

5 recordsLinked to original sources

Endometrial wavelike movements during the menstrual cycle.

OBJECTIVE: To qualify and quantify endometrial waves in regularly cycling women. DESIGN: A prospective transvaginal ultrasound study was performed throughout 23 cycles of 16 healthy women. Wave type and wave frequency were evaluated. SETTING: Normal human volunteers in an academic research environment. PATIENTS: Sixteen healthy regularly cycling women. RESULTS: Of 23 cycles, 19 proved to be ovulatory. Five types of endometrial waves could be distinguished. Waves from cervix to fundus and opposing waves were seen predominantly periovulatorily. Waves from fundus to cervix were absent in the postovulatory phase. Endometrial wavelike activity was most pronounced in the periovulatory phase. CONCLUSIONS: Standardized qualification and quantification of endometrial waves, as described in this study, might shed new light on the underlying mechanisms in selected cases of hitherto unexplained subfertility.

Adult

Self-control of interbeat interval and pulse transit time at rest and during exercise. A preliminary report.

Attempts were made to establish self-control of interbeat interval (IBI) and pulse transit time (PTT) by providing appropriate biofeedback information to volunteers at rest and during dynamic and isometric exercise. Product feedback (IBI X PTT) was found more reliable than simple heart rate (HR) and systolic blood pressure (SBP) during dynamic exercise. It also produced greater increases in IBI and PTT than did habituation or relaxation under the same conditions. Product feedback was also superior to the use of other techniques at rest, but PTT feedback did not produce significant control of pressor responses during isometric exercise. Possible reasons for this failure are discussed. Preliminary results of feedback training given to 7 anginal patients suggest that such procedures might help to lower nitroglycerin consumption, decrease the frequency of anginal attacks and increase exercise tolerance.

Angina Pectoris

The self-control of the cardiovascular response to exercise using feedback of the product of interbeat interval and pulse transit time.

Feedback of the product of interbeat interval and pulse transit time (this product being a close correlate of the product of heart rate and systolic blood pressure) was compared with relaxation training and simple habituation to the experimental task. The subjects were 36 healthy volunteers tested both when inactive and when cycling on a bicycle ergometer. Subjects receiving product feedback were markedly more successful in minimizing the decrease in interbeat interval and pulse transit time caused by exercise (i.e., their rate pressure product rose less). Subjects who received relaxation training or simply exercised showed similar changes in interbeat interval and pulse transit time. In the inactive subject, the superiority of product feedback was much less evident but it did enable subjects to increase pulse transit time (i.e., decrease systolic blood pressure) compared to the other two conditions, which again did not differ. It is proposed that the superiority of product feedback may relate to its value as an index of sympathetic input to the heart and that such feedback may find clinical application in the treatment of angina pectoris.

Adolescent