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Biomedical subjects

C R Nicholson

Publications and source records attributed to C R Nicholson.

At least 19 recordsLinked to original sources
PubMed1999

Ask the doctor. I've been taking tamoxifen for several months after completing treatment for breast cancer. My doctor prescribed it primarily to lower my risk of developing cancer in my unaffected breast. As a result of chemotherapy, I underwent menopause abruptly. Tamoxifen has worsened my symptoms, especially hot flashes and vaginal dryness. Other than stopping the tamoxifen, are there ways to deal with the side effects?

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Breast Neoplasms↗
PubMed1999

By the way, doctor. At my annual physical, I received cards to return to my doctor after collecting small samples of stool to test for fecal occult blood. I'm having trouble getting around to collecting these samples, because it is hard to get along without the motrin I take for back pain. The test materials instruct me to discontinue aspirin or NSAIDs and some foods for at least a week before collecting the samples. What should I do?

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Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1998

Retinal arterial macroaneurysm: a case report.

BACKGROUND: Retinal arterial macroaneurysms are an acquired retinal vascular abnormality. These isolated dilatations of the major retinal arterial branches are found within the posterior pole and are associated with systemic hypertension, arteriosclerosis, retinal emboli and cardiovascular disease. RESULTS: Although many patients are asymptomatic, vision loss is the most commonly manifested symptom. Vision loss may occur as a result of hemorrhage (subretinal, intraretinal, preretinal or vitreous) or macular edema with associated lipoprotein exudation. Most lesions spontaneously involute without causing any visual consequence. If central vision is reduced or threatened, laser photocoagulation may be applied directly to the macroaneurysm itself or to affected retinal capillary beds. While retinal arterial macroaneurysms frequently manifest as isolated phenomena with few symptoms (loss of visual acuity if bleeding or exudation encroaches on the macula), their differential diagnosis includes retinal and systemic diseases that require thorough investigation. CONCLUSION: Optometrists should be familiar with the signs and symptoms of retinal arterial macroaneurysms, their differential diagnosis, workup, and management.

Aged↗
PubMed1978

Short intensive topical APF applications and dental caries in a fluoridated area.

Three groups of approximately 200 children, consuming fluoridated water since birth, were given either 5, 10 or 25 consecutive topical applications with an APF gel (1.2% F, pH 3.2) in mouthpieces. After 1 year, mean DMFS increments were 7.2%, 30.4% and 35.3% less respectively for the three groups as compared with untreated control groups. Although enamel fluoride levels remained high after the 1st year, differences in dental caries increments between treated and control groups were too small to show group differences. The results suggest that in a fluoridated area, when caries activity is low, it would be difficult to show a long-term anticaries effect by increasing the fluoride concentration in sound enamel by a short series of self-applied topical fluoride applications.

Child↗
PubMed1977

Enamel fluoride uptake and retention from intensive APF gel applications in vivo.

Children, in the fifth school grade (mean age 11 years) in a fluoridated water area, self-applied acidulated phosphate-F gel (1.2% F) in custom-fitted mouthpieces on 5, 10, or 25 consecutive school days. Enamel F uptake, penetration, and retention were determined from analysis of 1,257 deciduous teeth exfoliated during and after the applications. F penetrated to 200 micrometer in enamel exposed to 25 applications of the gel and increased approximately 2,600 ppm at a 5 micrometer depth. Concentrations of F declined for approximately eight months after which levels stabilized, resulting in a 1,600 ppm increase of firmly bound F.

Acidulated Phosphate Fluoride↗