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Biomedical subjects

C R Noback

Publications and source records attributed to C R Noback.

At least 19 recordsLinked to original sources
PubMed1981

Some effects of protein-calorie undernutrition on the developing central nervous system of the rat.

Some effects of undernutrition were noted in the brains of 21-day-old pups undernourished from birth by being reared by nursing dams fed on a low protein diet. As compared to the normally fed control pups, the body weight, brain weight, and thickness of the parietal neocortex and paravermal cerebellar cortex were significantly lower in the undernourished pups (p less than 0.001), while the thickness of the cortices of the dentate gyrus and hippocampus CA3 only reached significance at the 5% level. Again, as compared to the control pups, the number of spines per unit length on the distal dendritic segments of the pyramidal cells of lamina III of the parietal neocortex and of the hippocampus CA3 reached significance at the 5% level whereas that of the granule cells of dentate gyrus and Purkinje cells of the paravermis did not reach significance at the 5% level. The myelination of the pyramidal tract and spinal trigeminal tract in the lower medulla was less advanced in the undernourished pups. To date, the demonstration of precise functional correlates for the observed changes of morphological and physiological parameters in animals subjected to undernutrition has been elusive. An approach that may lead to unraveling this problem is suggested in a discussion of relating sources of input to the specific dendritic segments where the spine counts were made.

Animals↗
PubMed1980

The ponto-cerebellar projection in the rat: differential projections to sublobules of the uvula.

Microinjections of horseradish peroxidase (HRP) were made in different sublobules of the uvula (lobule IX, a, b, and c of Larsell, 1952) of the cerebellar cortex in the rat. These injections resulted in retrograde labeling of cells located in the pontine nuclei. Sublobule IXa receives a predominant input from a single column of cells situated in a dorsointermediate position in the caudal pontine nuclei. Sublobules IXb and IXc receive a pontine projection from two different columns of cells, one medial and one lateral. The location of the labeled cells in the lateral part of the caudal pons suggests a topographic projection to the subdivisions of the uvula. Sublobule IXa receives a projection from a distinct dorsointermediate region and sublobule IXb and IXc receive a projection from partially overlapping ventral regions. The cells of origin in the medial pons are organized such that more dorsally located cells project to sublobule IXb and ventrally located cells project to sublobule IXb with extensive overlap. These differential patterns of projections to the sublobules of the uvula along with other data in the literature suggest that sublobule IXa may be involved with different functional correlates than sublobules IXb and IXc.

Animals↗
PubMed1980

Hypothermia after cardiopulmonary bypass in man: amelioration by nitroprusside-induced vasodilation during rewarming.

The incidence, time course, and magnitude of hypothermia following apparently adequate rewarming from hypothermic cardiopulmonary bypass (defined as a nasopharyngeal temperature [NPT] of 37 C) were studied in 20 adult patients (Group I). In each patient a decrease in NPT (averaging 2.6 +/- .2 C) occurred during the 80-min intraoperative postbypass period. The NPT had stabilized approximately 45 min after the end of bypass. Eight additional patients (Group II) received pharmacologic vasodilation with nitroprusside during the rewarming period. Pump flow was increased as nitroprusside was infused to maintain mean arterial pressure greater than or equal to 70 torr. Group II patients maintained NPT significantly better in the postbypass period than did Group I patients (NPT decrease of 1.5 +/- .4 C, P < 0.01, a 42 per cent improvement). As in Group I, NPT in Group II had stabilized 45 min after bypass. Ambient air temperatures between 18 and 23 C had no effect on NPT decrease. Presumed peripheral heat delivery was found to be greater in Group II. It is concluded that postbypass NPT decreases occurred in all patients, but that these decreases were significantly lessened by pharmacologic vasodilation plus deliberately increased pump flow during rewarming on bypass.

Cardiopulmonary Bypass↗