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Biomedical subjects

C R Pfaltz

Publications and source records attributed to C R Pfaltz.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

Human leukocyte antigens in patients with inner ear diseases of unknown etiology.

The immune response genes that control the immune response and recognition of 'self' from 'nonself' are closely linked with the human leukocyte antigen (HLA) complex. Sixty-six HLA antigens were typed in 42 Caucasian patients with inner ear diseases of unknown etiology. All of these patients had positive serum antibodies against the inner ear structures as detected by an indirect immunofluorescence assay. Results revealed that none of the 66 HLA antigens was associated with the inner ear diseases. Reviewing results from other studies on HLA association in inner ear diseases shows that the findings are inconsistent with each other. The conclusion that HLA associations occur with inner ear diseases cannot be reached.

Adult↗
PubMedDate not supplied

Complications of acute middle ear infections.

Although acute mastoiditis and intracranial otogenic complications occur less frequently in our time than in the preantibiotic period, the disease is nevertheless still a rather severe medical problem. Its mortality rate remains relatively high and the severity of its symptoms is often underrated or misinterpreted by the inexperienced physician. On the basis of some personal clinical observations made during the last decade, attention has been drawn to the most common intracranial and extracranial otogenic complications in adults and children. It may therefore be concluded that otitis media must still be considered a dangerous disease, necessitating fundamental knowledge of its underlying pathology, which provides a basis of early correct diagnosis and adequate intensive therapy.

Acute Disease↗