MORPHINE SELF-ADMINISTRATION, FOOD-REINFORCED, AND AVOIDANCE BEHAVIORS IN RHESUS MONKEYS.
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Biomedical subjects
Publications and source records attributed to C R SCHUSTER.
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Rats were able to adjust to two different temporal requirements within several multiple DRL schedules of reinforcement, and a slight induction between pairs of components was found. Initial administration of dl-amphetamine differentially disrupted spaced responding in the components of a multiple DRL 36 DRL 18 schedule, but did not eliminate discrimination between the components. After maximum drug effects, the continued administration of dl-amphetamine was accompanied by a progressive recovery of the behavior towards the characteristics of saline control.
A technique is described for self-infusion of pharmacologic agents in solution through a permanently indwelling jugular catheter in the rhesus monkey. The results of an experiment utilizing this technique demonstrate that an instrumental lever response can be conditioned, extinguished, reconditioned, and brought under stimulus control and reward-schedule control with saline self-infusion as the reinforcing stimulus.
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