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Biomedical subjects

C R Santerre

Publications and source records attributed to C R Santerre.

8 recordsLinked to original sources
PubMed2005

Predicting toxicity equivalents in fish tissue.

Toxicity equivalents is a measure of "dioxin-like" toxicity contributed by polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (dioxins), and polychlorinated dibenzofurans (furans). Calculation of toxicity equivalents require the use of analytical procedures that are expensive and slow, making them impractical for routine analysis. U.S. Environmental Protection Agency National Fish Tissue Study (2003) data were used to determine the most significant predictors of toxicity equivalents with multiple regression analysis. The strongest predictive model (P < 0.0001, R2 = 0.97) included five compounds (PCB-118; PCB-126; 2,3,7,8-TCDD; 1,2,3,6,7,8-HxCDD; 2,3,4,7,8-PeCDF). However, the required lower limit of detection for an analytical method measuring these congeners is 0.1 ppt and would not provide much benefit over the current analytical method. An alternative model (P < 0.0001, R2 = 0.68) that included three PCBs (PCB-138, PCB-153, PCB-118) would require a limit of detection of 1,000 ppt and be more practical. This research demonstrates that the measurement of selected compounds can be used to estimate toxicity equivalents and consequently serve as the impetus for the development of lower cost, rapid analytical methods for analysis of fish.

Animals↗
PubMed2005

Mercury and omega-3 fatty acids in retail fish sandwiches.

Mercury and fatty acids were measured in fish sandwiches from six retail restaurant chains. Average mercury concentrations ranged from 5 to 132 ppb and were well below the Food and Drug Administration action level (1,000 ppb). The average concentrations of eicosapentaenoic acid plus docosahexaenoic acid ranged from 91 to 620 mg per sandwich. Consuming one or two fish sandwiches per week could result in the consumption of 2 to 40% of the reference dose for mercury for a 60-kg individual and would provide 18 to 126% of the adequate intake for eicosapentaenoic acid plus docosahexaenoic acid as recommended for a pregnant or lactating woman.

Animals↗
PubMed2005

Analysis of mercury in sportfish tissue by thermal decomposition, amalgamation/atomic absorption spectrophotometry.

Sportfish samples (n = 133) that originated from Indiana waters were analyzed for total mercury using inductively coupled plasma/mass spectrometry (ICP/MS) and thermal decomposition, amalgamation/atomic absorption spectrophotometry (TDA/ AAS). Total mercury concentrations obtained by the two methods were not significantly different (P > 0.05). The correlation coefficient for total mercury obtained for the two methods was 0.94. The limit of detection using TDA/AAS was 0.1 ppm. TDA/AAS is a preferred technique for the analysis of total mercury in fish tissue because it is rapid (6 min per sample) and easy to use and requires little sample preparation.

Animals↗
PubMed2004

Prediction of PCB content in sportfish using semipermeable membrane devices (SPMDs).

Triolein-filled semipermeable membrane devices (SPMDs) were immersed at three locations along the St. Joseph River in northern Indiana for 30 days to see if the PCB content of fish from the same location could be predicted with this model device. Triolein from the SPMD's was analyzed for PCB using enzyme-linked immunosorbent assay (ELISA) and compared to residues detected in fish collected from the same locations. There was a significant difference (p < 0.05) in total PCB concentrations between SPMD samples. However, due to variability in PCB residues between species and low PCB residues in SPMDs, a direct correlation between PCBs in sportfish and SPMDs could not be determined.

Animals↗
PubMed2004

Measurement of polychlorinated biphenyls in fish tissue by gas chromatography with electron capture detection and enzyme-linked immunosorbent assay.

Polychlorinated biphenyls in fish tissue were analyzed by enzyme-linked immunosorbent assay (ELISA) and gas chromatography with electron capture detection (GC/ECD) methods. Fish samples were collected in 2000 and 2001 during an Indiana fish survey. For samples with concentrations ranging from 0.05 to 0.5 ppm (n = 40) and 0.5 to 5.0 ppm (n = 12), the ELISA results were not significantly different from GC/ECD (P < 0.05). This research has demonstrated the effectiveness of analysis of fish samples by ELISA in the development of fish consumption advisories that accurately articulate health risks from the consumption of contaminated fish.

Animals↗
PubMed2000

Chlordane and toxaphene residues following cooking of treated channel catfish fillets.

The reduction in residues of chlordane and toxaphene following cooking (frying, baking, and smoking) of fillets obtained from treated Channel catfish (Ictalurus punctatus) was determined. On average, cooking reduced moisture content by 17% and increased fat content by 28 to 274%. Frying reduced chlordane residues by 56 to 86% on a dry basis (db) or 84 to 92% on a percent fat basis (fb) when raw fillets were compared to cooked fillets. Baking and smoking reduced chlordane significantly less (P < 0.05) than frying with reductions in residues of 12% and 9% (db) or 30% and 33% (fb), respectively. Frying reduced toxaphene residues by 40 to 49% (db) or 65 to 77% (fb), while baking and smoking reduced toxaphene by 35% and 24% (db) or 51% and 59% (fb), respectively.

Animals↗
PubMed1993

Wipe testing for surface contamination by tritiated compounds.

This study investigated the performance of the wipe test in determining contamination from tritiated triolein or thymidine on various surfaces. Filter papers were saturated with water, methanol, petroleum ether, ethyl acetate or maintained dry, and wipes were taken from lead, stainless steel, polyurethane, wood, painted lead, treated floor tile, Formica, or bench paper that were spotted with either 3H-thymidine or 3H-triolein. The recovery of contamination using the dry wipe test averaged 3% for all surfaces. Recoveries using wet wipes were directly related to the solubility of the tritiated compounds in the wipe solution and the physical nature of the wipe surface.

Equipment Contamination↗