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Biomedical subjects

C R Showalter

Publications and source records attributed to C R Showalter.

10 recordsLinked to original sources

Work-related stress in American trial judges.

This study examines work-related stress among American trial judges using a relational model of stress, which emphasizes an individual's appraisals in a person-situation relationship. A representative sample of 88 judges completed three questionnaires addressing type and magnitude of specific work-related stressors, psychological stress symptoms, and psychosocial moderators of stress. Factor analysis revealed five types of stressors: case, litigating party, purposes and consequences of decisions, conflicts between professional and personal values, and seriousness of a criminal offense. The most stressful aspects of work relate to poorly prepared or disrespectful counsel, exercising judicial management and discretion, and highly emotional cases under public scrutiny. Correlational analyses show that stress is associated with cognitive, emotional, and behavioral symptoms, including a possible adverse impact on decision-making capacity. Results are discussed in terms of the relational model of stress.

Decision Making↗

Alterations in the sialylation and sulfation of secreted mouse thyrotropin in primary hypothyroidism.

We investigated the effect of in vivo hypothyroidism on the sialylation and sulfation of thyroid-stimulating hormone (TSH) secreted by mouse pituitary explants. Oligosaccharides from secreted thyroid-stimulating hormone from hypothyroid animals contained greater sialic acid relative to sulfate in both alpha and beta subunits. Aging per se had little effect on thyroid-stimulating hormone sialylation or sulfation. Variable sialylation and sulfation demonstrates a mechanism for charge microheterogeneity of thyroid-stimulating hormone, and the increasing sialylation observed with hypothyroidism may functionally mediate the prolonged metabolic clearance that has been noted previously.

Aging↗

Primary hyperparathyroidism, hypercalcemia, paranoid delusions, homicide, and attempted murder.

This report describes a case of primary hyperparathyroidism in a 68-year-old man. The endocrine disorder, while suspected before the commission of homicide and attempted murder, was proven biochemically and histologically a number of months after the commission of the crimes. The acts of homicide and attempted murder followed the development of paranoid delusions, which rapidly resolved upon successful removal of a single cystic parathyroid gland adenoma. The unusual events that immediately followed the acts of violence indicate that the delusions occurred in a clear sensorium (absence of delirium). Psychological measures taken before and after surgery document improvement in subtle organic functioning while intelligence was unchanged. This report discusses the neuropsychiatric manifestations of hypercalcemia and reviews the literature.

Adenoma↗