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Biomedical subjects

C R Steer

Publications and source records attributed to C R Steer.

11 recordsLinked to original sources

Managing attention deficit/hyperactivity disorder: unmet needs and future directions.

The management of attention deficit/hyperactivity disorder (ADHD) requires a multimodal approach. Although shared-care protocols are suggested, uptake by general practice has been tentative. Behavioural management, both on its own and in combination with pharmacotherapy, reduces core symptoms and associated behaviours, such as oppositional defiant disorder (ODD). Links with education and social support are also important for helping children and their families. Psychostimulants have shown to be effective in the treatment of ADHD, however, their short duration of action highlights potential limitations. Other drugs used in the management of ADHD and comorbid disorders include antidepressants, clonidine and its analogues, newer atypical neuroleptics, and atomoxetine, a novel, non-stimulant therapy that has potential to fulfil some unmet treatment needs. Further research is needed in preschool children, girls, those with epilepsy, young adults, and in those with associated sleep disturbance. Selected rating scales and careful history taking, allied to close links with schools, are vital for the initial and ongoing assessment of ADHD and its comorbidities.

Adolescent↗

Your child is brain dead.

One to two per cent of admissions to Paediatric Intensive Care Units eventually fulfil the criteria for brain death, implying the need for very difficult decisions. Brain death is defined as irreversible loss of function of the whole brain. The diagnostic criteria caused a great deal of anxiety but are now the subject of a consensus approach. When the situation can be anticipated it is of immense value for the professional staff to develop a good working relationship with the parents to help and support them through the phase of impending disaster and facing the issue when the time actually comes. However, it is vital to help parents to make their own decision regarding continuation or otherwise of life support and they should be supported in whichever decision they take. They must be absolutely convinced that the child is brain dead and this territory may have to be covered again and again in discussion, questions must be answered factually, and time allowed for reflection. Stage management of the process of 'switching off' is vital and the parents' wishes may vary widely from one family to another. They must be warned what is likely to happen and provided with appropriate privacy and support for expression of their grief. The question of asking for post-mortem permission has to be handled sensitively and long-term support for the parents must be offered. Education of undergraduate and postgraduate doctors in this area is now receiving more attention with skills being increased by video teaching and role play. It should not be overlooked that the professional staff attending such patients sometimes require counselling and support themselves.

Brain Death↗

Pulmonary eosinophilia associated with carbamazepine.

An 8 year old girl treated with carbamazepine developed eczema, wheeze, and evidence of pulmonary eosinophilia. Single dose challenge confirmed allergy to this drug. This reaction should be considered in patients being treated with carbamazepine who develop respiratory symptoms.

Carbamazepine↗

Rigid spine syndrome and fatal cardiomyopathy.

A 7 1/2-year-old girl had the clinical features of the rigid spine syndrome of Dubowitz. Muscle biopsy showed a predominance of type 2 fibres with neither myopathic features nor an increase in connective tissue. In addition, she had a hypertrophic cardiomyopathy with which she presented in heart failure and from which she died suddenly one month later. The association of rigid spine syndrome with cardiomyopathy has not been reported previously.

Cardiomyopathy, Hypertrophic↗

Misleading plasma electrolytes in diabetic children with severe hyperlipidaemia.

Severe abnormalities of plasma electrolyte concentrations were observed in 4 children who had massive hyperlipidaemia secondary to poorly-controlled, insulin-dependent diabetes mellitus. These electrolyte values were fallacious and invoked problems of clinical management, particularly with regard to fluid replacement. Each case is described and the interpretation of plasma elecytolyte values in hyperlipidaemia is discussed.

Adolescent↗