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Biomedical subjects

C R Wright

Publications and source records attributed to C R Wright.

7 recordsLinked to original sources
PubMed1972

Incidence of -thalassaemia trait among Cypriots in London.

The incidence of beta-thalassaemia trait among Cypriots in London is about 14%, and the birth rate of children with thalassaemia major is 0.6%. The high incidence of the beta-thalassaemia gene among Cypriots suggests the desirability of screening Cypriot school-leavers for thalassaemia trait and following up any incidentally discovered cases with family studies and genetic counselling.

Cyprus↗
PubMedDate not supplied

Levels and temporal trends of trace element concentrations in vertebral bone.

An X-ray fluorescence analysis study of iron, zinc, rubidium, strontium, and lead in ashed vertebral column whole bone samples of 51 sudden death victims in Western Australia gave median values of 893, 213, 25, 108, and 25 ppm, respectively. Highly significant concentration-age Spearman correlations were observed for iron-age (rs = 0.45, P less than .004), Zn-age (0.43, P less than .006), and lead-age (0.63, P less than .001), the mean per annum rates of increase being 26, 0.4, and 0.8 ppm, respectively, and marked concentration-concentration correlations were found for iron-lead (0.44, P less than .003) and strontium (0.30, P less than .06). The median zinc concentrations for the male and female subsets are 216 and 205 ppm, respectively; the corresponding values for strontium are 100 and 120 ppm.

Adolescent↗
PubMedDate not supplied

Fine-bore peripheral catheters versus central venous catheters for delivery of intravenous nutrition.

We present a descriptive study of 229 consecutive inpatients requiring intravenous nutrition. These patients received either complete peripheral intravenous nutrition via a fine-bore silicone catheter (n = 80) or short Teflon catheter (n = 15) or received conventional central intravenous nutrition (n = 134). Nutrient delivery was similar for both systems, providing 0.2-0.4 g N.kg-1 x day-1 and 0.13-0.15 mJ.kg-1 x day-1 from preparations containing 4.3 MJ/L total energy (65-75% lipid: 25-35% glucose for peripheral support and 100% glucose for central delivery) with 6 g N/L. We compared the incidence of catheter complication and the probability of catheter function over time for the peripheral and conventional central systems. Venous access complications were seen only with central venous catheterization (10.4%). Chemical phlebitis occurred in 17% of fine-bore catheters and 91.4% of Teflon catheters. The infective phlebitis rate of fine-bore silicone catheters was 1.02% and daily risk of phlebitis 0.016%, with no instance of device-related bacteremia or sepsis. Central-line microbial contamination (21.7%) and catheter-related sepsis (3%) were significantly greater (p < 0.0005, chi 2 goodness-of-fit test) than with fine-bore silicone and Teflon catheters. The probability of complication-free function against time was similar (0.75 < p < 0.90, log-rank test) in fine-bore silicone catheters and central venous catheters. We conclude that fine-bore silicone catheters provide long-term phlebitis-free delivery of complete peripheral intravenous nutrition.

Adult↗