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Biomedical subjects

C Raulin

Publications and source records attributed to C Raulin.

At least 19 recordsLinked to original sources

[Laser therapy for vascular lesions].

The use of lasers to treat vascular lesions began in the late 1960s with the introduction of argon laser. More recently pulsed laser and intense pulsed light techniques have further improved results and reduced side effects. Their function is based on the principle of selective photothermolysis. Simultaneous application of cooling methods (contact cooling, cold air, cryogen spray) has become standard procedure for these types of therapy, whose most important indications are port-wine stain, hemangioma, and telangiectasia. A persistent difficulty is their limited penetration, resulting in limited or no effect on deeper dermal layers. New approaches therefore include combinations with bipolar radio frequency or the use of two different laser systems, e.g., dye and Nd:YAG lasers. The different lasers are described along with their effectivity, limitations and indications.

Combined Modality Therapy↗

Electro-optical synergy (ELOS) technology for nonablative skin rejuvenation: a preliminary prospective study.

BACKGROUND AND OBJECTIVES: In this preliminary prospective study, we evaluated the efficacy and safety of nonablative wrinkle treatment using combined radiofrequency (RF) and optical energy (Polaris). The dual energy technology of Polaris, called ELOS, which stands for electro-optical synergy, uses synchronous pulses of bipolar RF current and pulsed visible light (diode laser) delivered in the same pulse. MATERIALS AND METHODS: Twenty-four subjects with periorbital and perioral wrinkles received six treatments at 4-week intervals with the Polaris WR (Syneron, Inc., Israel, 900 nm, max. RF energy 100 J/cm(3), max. laser energy 50 J/cm(2)). Each treatment consisted of two passes over the treatment area using pulsed optical and RF parameters that were determined by the patient's skin phenotype and distribution of target chromophores. The follow-up period was 3 months after the last treatment. RESULTS: Independent scoring of blinded photographs showed a wrinkle score improvement of at least 1 (0 = no improvement, 1 = medium, 2 = good, 3 = excellent improvement) 3 months after the last of six treatment sessions. There was no difference between periorbital and perioral wrinkle reduction. Fifty-eight per cent (14/24) of the subjects reported a notable wrinkle reduction; 16% noted mild to moderate oedema and erythema lasting for no more than 1 day. Scarring or pigmentary changes were not detected. The average pain score was 0.6 (0 = no pain, 5 = intolerable pain). CONCLUSION: Multiple treatments with the Polaris WR produced objective and subjective reduction of periorbital and perioral wrinkles. The occurrence of side-effects and pain was very low. The clinical effect may be caused by matrix coagulation of the deep dermis by the RF and selective thermolysis of blood vessels with the 900 nm diode laser.

Adult↗

[The excimer laser in dermatology and esthetic medicine].

First reports about the use of the excimer laser in dermatology date back to 1997. It is seen as an improvement on conventional phototherapy and photochemotherapy because of the lower cumulative UV-dose involved, the shorter time frame required for treatment and the option of targeting individual lesions without affecting the surrounding healthy skin. In addition to the indications of psoriasis vulgaris, vitiligo and atopic eczema (for which there is now FDA approval in the US), the spectrum of possible uses for the excimer laser is growing rapidly, especially in the field of light-sensitive dermatoses. Case studies so far have ranged from post-operative hypopigmentation to acne vulgaris and from alopecia areata to parapsoriasis en plaque. The foremost priorities in the future will be to evaluate reproducible therapeutic regimens with realistic prospects of success in large-scale studies; assess potential iatrogenic risks in treatment; develop pathogenetic models for the mechanism of action; and define therapeutic approaches to new indications. This paper summarizes the publications to date and discusses our observations and experiences.

Acne Vulgaris↗

[Reticulohistiocytoma. Treatment with pulsed-dye laser].

Reticulohistiocytoma is a rare non-Langerhans-cell histiocytosis. On exposed skin areas it is a cosmetic problem and can cause mechanical irritation due to its prominent nature. We successfully treated a histologically confirmed reticulohistiocytoma on the back of a 60 year old woman with a pulsed dye-laser (wavelength 585 nm, pulse 0.45 msec). The lesion regressed significantly after the first treatment (spot size: 7 mm, fluence 7.8 J/cm(2)). After another laser treatment, the lesion completely disappeared. At 28 month follow-up, no recurrence was seen. Permanent side effects were not observed. In our case report the use of the pumped pulsed dye-laser has proven to be an elegant and low risk treatment option for reticulohistiocytoma. The mechanism of action remains unknown.

Female↗

[Repigmentation of persistent laser-induced hypopigmentation after tattoo ablation with the excimer laser].

Hypopigmented skin developed following tattoo removal with the Q-switched Nd:YAG laser. The hypopigmented area remained unchanged for over 4 years, until the use of the 308-nm xenon-chloride excimer laser induced a significant repigmentation in 40 sessions over 14 months. The excimer laser has the potential to influence the reduced activity of the melanocytes, as demonstrated with electron microscopy.

Adult↗

[Excimer laser. Treatment of iatrogenic hypopigmentation following skin resurfacing].

As skin resurfacing has become more common, the number of patients developing post-treatment hypopigmentation has increased. No effective treatment for this complication has been developed. Some hypopigmented disorders, including vitiligo, have been treated with the excimer laser. We used the XeCl excimer laser to successfully treat a 78-year-old woman with perioral leukoderma following CO(2) laser skin resurfacing. The repigmentation was stable for at least 16 months. Larger prospective studies of this new therapeutic intervention are recommended to evaluate its efficacy and long-term stability.

Aged↗

[Facial folliculo-sebaceous cystic hamartoma. Treatment with CO2 and Er:YAG lasers].

Folliculo-sebaceous cystic hamartoma (FCH) is defined as an adnexal hamartoma. The histopathological findings of FCH are equivalent to a very late stage of trichofolliculoma. The clinical appearance of FCH is unspecific. For this reason in the majority of cases it is only the histopathological examination that leads to the diagnosis of FCH. Up to now FCH has been treated with surgical procedures. We combined the use of both CO2 and Er:YAG lasers to treat a facial FCH.

Combined Modality Therapy↗

[Medical dermatologic laser therapy. A review].

The medical indications for laser therapy have been somewhat overlooked, perhaps because of the success of cosmetic laser therapy. As a result, many effective medical treatments are not covered by insurance companies. Lasers are helpful in many aspects of dermatologic treatment. Examples include pigmented lesions (Becker nevus), benign tumors (organoid nevi, adenoma sebaceum), dyschromias (traumatic tattoos), inflammatory diseases of the skin and subcutaneous tissue (lupus erythematosus, scars), hypertrichosis, premalignant lesions, and vascular lesions (hemangiomas and malformations). The various disorders which can effectively be treated with lasers are reviewed.

Adenoma↗

[Diffused traumatic dirt and decorative tattooing. Removal by Q-switched lasers].

BACKGROUND AND OBJECTIVE: Pigment fanning or spread is one complication of decorative tattooing, but is also seen after traumatic tattoos. The reason for this spreading remains unclear. While excision of the diffused pigment was previously considered the treatment of choice, today destruction of the pigment with Q-switched laser systems is the therapy with the highest efficiency and lowest rate of side effects. Therefore areas of pigment spread should be excised only in rare exceptional cases. PATIENTS/METHODS: 4 patients with pigment fanning after permanent make up and traumatic tattooing of the periorbital region were treated with the Q-switched ruby (694 nm) and Q-switched Nd:YAG (1064 nm) lasers. RESULTS: All patients showed a significant (70-80%) clearance of the spread pigment; two had complete clearing. Side effects such as hyper- or hypopigmentation, scarring or ink darkening were not seen. CONCLUSIONS: The Q-switched ruby- and Q-switched Nd:YAG-lasers are a therapeutic modality for pigment fanning with high efficiency and low rate of side effects. Attempts of explanation for pigment spread after tattoos are given, but further histological and electron microscopical investigations are needed to find the pathogenetic mechanism.

Child↗

[From Einstein's Quantum Theory to modern laser therapy. The history of lasers in dermatology and aesthetic medicine].

Laser technology has considerably expanded therapeutic modalities in dermatology and aesthetic medicine. In addition, lasers have broadened the spectrum of diagnostic and therapeutic options in many other medical fields. Dermatologists, especially Dr. Leon Goldman, played an important role in the evolution and use of medical lasers. There was a long way from the concept of stimulated emission as the fundamental idea of laser technology by Albert Einstein in 1917 to the practical use of the laser today. We review the development of laser technology from the early days through the latest advances.

Animals↗

[CO(2) and Er:YAG lasers in dermatology and aesthetic surgery].

In the past few years, the spectrum of indications for ablative lasers in dermatology and aesthetic medicine has been expanded due to technological innovations. In the following, technical basics, laser-tissue interactions, indications for the CO(2) and Er:YAG laser and laser treatment management are described. In addition, side effects and reactions associated with the use of these laser systems are listed and compared.

Humans↗

["Skin rejuvenation" by non-ablative laser and light systems. Literature research and overview].

Currently, ablative laser therapy (with CO2/Er:YAG lasers) and deep chemical peeling are effective and promising methods of skin rejuvenation. The induction of collagen synthesis was observed after peelings with trichloroacetic acid or phenol as well as after treatments with the CO2 laser. In past years, the undesirable side effects and risks of these methods have led to intensified research in the fields of non-ablative facial rejuvenation and subsurfacing by means of ablative laser systems and intense pulsed light systems. The objective is to achieve selective, heat-induced denaturalisation of dermal collagen that leads to subsequent reactive synthesis but does not damage the epidermis. Recently, the results of numerous clinical and histological studies have indicated that these new technologies are successful. After critical review and assessment of current literature, we can say that in terms of their efficacy, non-ablative methods are not a comparable alternative to ablative skin resurfacing.

Female↗

Retrospective clinical comparison of hemangioma treatment by flashlamp-pumped (585 nm) and frequency-doubled Nd:YAG (532 nm) lasers.

BACKGROUND AND OBJECTIVE: Laser therapy using the flashlamp-pumped pulsed dye laser (FPDL), along with contact cryotherapy, has proven to be an effective method with few side effects in the early treatment of superficial hemangiomas in infancy. The long-pulsed frequency-doubled Nd:YAG laser (VersaPulse) is a new kind of laser whose efficacy and safety we examined in direct comparison with the FPDL. STUDY DESIGN/MATERIALS AND METHODS: In a retrospective comparative study, we treated 50 infants with a total of 62 superficial hemangiomas. A total of 29 hemangiomas were treated with the FPDL (wavelength 585 nm, impulse duration 0.3-0.45 msec), 33 with the VersaPulse (wavelength 532 nm, impulse duration 1-50 msec). With an average of 3.0 and 2.6 treatments (FPDL/VersaPulse respectively), a cessation of growth or regressive tendency could be achieved in 93% and 70% of the hemangiomas, respectively. Complete regression occurred in 41% (FPDL) or 30% (VersaPulse). Only in 7% (FPDL) or 18% (VersaPulse) was there progression despite laser therapy. The side effect rates of both laser systems were low. CONCLUSION: The FPDL has proven to be the slightly more effective treatment method in comparison and, therefore, remains the therapy of choice for the initial treatment. If parents wish to pursue further treatment in the regression phase of hemangiomas to optimize the cosmetic appearance, we recommend the VersaPulse due to its low rates of side effects and painfulness.

Female↗

Circumscripted pigmentations after iron injections-treatment with Q-switched laser systems.

BACKGROUND AND OBJECTIVE: Cutaneous brown discolorations in the area of injection can be a cosmetically bothersome side effect from a parenteral iron treatment, and have not responded to an effective therapy until now. STUDY DESIGN/PATIENTS AND METHODS: We report retrospectively on five patients who were treated with the Q-switched ruby and/or Nd:YAG laser for circumscripted siderosis after intramuscular or intravenous iron injection. RESULTS: The number of required laser treatments was between 3 and 16. The clinical improvement after the first 2-4 sessions was the most impressive, especially after the application of the Nd:YAG laser. Hypopigmentation and scars did not develop. In one case hyperpigmentation appeared. CONCLUSIONS: This study shows that there is an effective method of clearing persistent brown discolorations with few side effects after parenteral iron therapy, using Q-switched laser technology.

Adult↗

Treating REM syndrome with the pulsed dye laser.

BACKGROUND AND OBJECTIVE: REM syndrome (reticular erythematous mucinosis) is a benign but bothersome skin disease that common occurs in middle age and among women. Local and systemic treatment measures are often associated with a high rate of side effects and relapses are common. We evaluated the pulsed dye laser as an alternative method because of its good efficacy in vascular skin diseases. STUDY DESIGN/MATERIALS AND METHODS: We treated two female patients with REM syndrome using the pulsed dye laser. RESULTS: In both patients the erythematous skin changes were almost completely removed after five and three laser sessions, respectively. Other than transient hypopigmentation, no side effects occurred. In one case there is still no evidence of recurrence 6 years after a trial treatment was conducted. In the same patient, clinical success was histologically confirmed. CONCLUSIONS: This is the first report on the successful treatment of REM syndrome of two female patients with the pulsed dye laser.

Adult↗

[Molluscum contagiosum: treatment with pulsed dye laser].

BACKGROUND AND OBJECTIVE: There is a wide variety of methods for the treatment of mollusca contagiosa. Especially with anxious children, most of them are not applicable because they are often invasive, painful, time intensive or difficult to conduct (e.g. if a stay in hospital is necessary). In order to verify the existing case reports, this paper evaluates the application of the pulsed dye laser as a possible therapy alternative in cases of mollusca contagiosa. PATIENTS/METHODS: In a prospective study 20 patients with mollusca contagiosa were treated with the pulsed dye laser. RESULTS: The therapy was well tolerated; no scars or pigment anomalies were observed. 95.9% of the lesions healed after the first treatment, the other 4.1% after the second. This larger study verifies the positive findings indicated in case studies. CONCLUSIONS: For exposed sites, difficult cases or if other treatment methods have failed, the pulsed dye laser is an effective, quick, bloodless and elegant therapeutic alternative for mollusca contagiosa with a low rate of side effects.

Adolescent↗

[Benign melanosis of the lip. Treatment with the Q-switched ruby laser].

BACKGROUND AND OBJECTIVE: Benign melanosis of the lip represents a cosmetic problem for many of those who are afflicted. It responds well to therapy with Q-switched lasers. The value of previous studies has been limited by small numbers of cases or short follow-up times. PATIENTS/METHODS: In a retrospective study 9 patients were treated by the Q-switched ruby laser (694 nm, pulse duration 25-40 ns, spot size 4 mm, energy density 10 J/cm2) in the period from 5/94 to 10/99. The benignity of the lip melanosis was determined dermatoscopically. In one case, the diagnosis was also confirmed histologically by a punch biopsy. The follow-up time was between 6 months and 5 1/2 years. RESULTS: In 3 cases a complete clearance of the melanosis was achieved after one session, while in 6 patients a second treatment was required. There were no recurrences. Scars or pigment alterations were likewise not observed. CONCLUSIONS: The treatment of benign melanosis of the lip with the Q-switched ruby laser is an elegant and safe method with excellent cosmetic results.

Adult↗