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C Rea

Publications and source records attributed to C Rea.

32 records · Page 2Linked to original sources
PubMed1974

Regulation of amino acid transport in kidney cortex of newborn rats.

After incubation at 37 degrees C the subsequent uptake of alpha-aminoisobutyric acid, cycloleucine, glycine, and L-proline by newborn (as compared to adult) rat kidney cortex slices is enhanced. The effect is abolished by the presence of cycloheximide, actinomycin D, and high concentrations of the above-mentioned amino acids in the medium during the 37 degrees C incubation prior to measurement of uptake. The data suggest that there is an adaptive control mechanism which is expressed on incubation at 37 degrees C and which can regulate amino acid transport in newborn rat kidney cortex.

Amino Acids↗
PubMed1971

Separate transport systems for sugars and amino acids in developing rat kidney cortex.

The ability of renal cortical slices of newborn and young rats to accumulate a nonmetabolizable sugar, alpha-methylglucoside, is slight and does not reach adult capacity until 25 days of age. However, a rudimentary sugar transport system is present, as indicated by a further decrease in accumulation in the presence of phlorizin or absence of sodium ion.Amino acid uptake in immature kidney tissue is not deficient; on the contrary, the tissue took up and concentrated more glycine and lysine than adult tissue. Decreased amino acid efflux from the immature cells appears to be the explanation. Concentration dependence of amino acid uptake was the same in 5-day-old and adult tissue. These differences between the transport characteristics of a model sugar and representative amino acids during development indicate separate transport systems for the two types of substrate.

Amino Acids↗
PubMedDate not supplied

Clinical directorates.

Ten years ago the number of hospitals which had adopted a clinical directorate model of management could have been counted on the fingers of one hand. Today those that have not adopted some variant of the model can be counted in the same way: a meteoric rise by NHS standards.

Hospital Departments↗