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C Reisser

Publications and source records attributed to C Reisser.

27 records · Page 2Linked to original sources
PubMed1992

[Diagnosis of energy metabolism in ENT tumors--a PET study].

The metabolism of malignant tumours can be determined in vivo by positron emission tomography. Fifty patients with malignant lesions of the head and neck were examined before therapy and followed up for 11-18 months. The course of the disease was related to the initial fluorodeoxyglucose (FDG) uptake of the tumour. There was a relation between FDG uptake and survival: an increased FDG uptake of more than 300-400% was related to a reduced survival rate. Patients with an uptake less than 300% had a much better prognosis.

Blood Glucose↗
PubMed1992

[Positron emission tomography (PET) in the evaluation of tumor proliferation and follow-up of therapy in ear, nose and throat tumors].

The uptake of 18F-Deoxyglucose (FDG) was studied in vivo in patients with head and neck tumors with positron emission tomography (PET) in relation to the proliferation rate of these tumors. The quantitative analysis of the radioactivity concentrations revealed two groups, showing a high or a lower FDG uptake pattern. In both groups the FDG uptake and the proliferation rate were correlated with a flat slope of the regression function. It is suggested that these differences in uptake in histologically identical tumor populations may correspond to differences at the molecular level, e.g. differences in the amount of the glucose carrier, perhaps caused by activated oncogenes. Furthermore PET was applied to evaluate therapeutic effects in patients with advanced head and neck cancer. We found that multiple lymph node metastases in the same patient can show a different baseline metabolism and also different changes following therapy. Tumors were more sensitive to therapy than lymph node metastases. The growth rate and the change in FDG uptake were highly correlated with different regression functions for tumors and lymph node metastases. These data demonstrate that PET with FDG can be used to assess early chemotherapeutic effects. The information gained with PET can be included in the treatment planning in patients undergoing systemic chemotherapy.

Carcinoma, Squamous Cell↗
PubMed1991

[PET scan in tumor diagnosis in the head and neck].

PET, a new method in nuclear medicine, allows the in vivo measurement of tumor metabolism and tumor perfusion. Absolute and standardized PET data can be used for comparative examinations before, during and after therapy. It thereby is possible to assess very early the efficacy of a therapy and also to change the therapeutic scheme. Furthermore PET studies with multiple parameters allow the evaluation of the biological behaviour of the tumor and yield information that is relevant for prognosis.

Energy Metabolism↗
PubMed1991

The anterior inferior cerebellar artery in the internal auditory canal.

It has been proposed that compression of the auditory and vestibular nerve trunks by vascular loops might be the cause of otherwise unexplained hearing loss, tinnitus, and vertigo, as well as Meniere's disease. We studied the human temporal bone histological collection at the Massachusetts Eye and Ear Infirmary to determine whether audiovestibular symptoms could be correlated with the presence of the anterior inferior cerebellar artery within the internal auditory canal. Anterior inferior cerebellar artery loops were found within the internal auditory canals of 12.3% of 1327 temporal bones, about half the number found when preparations with intact brains are studied. This difference can be attributed to avulsion of the anterior inferior cerebellar artery during removal of the brain at autopsy. There were 5 cases of unexplained unilateral hearing loss with anterior inferior cerebellar artery loops: 3 in the opposite ear and 2 in both ears. There were 2 cases with unilateral unexplained tinnitus with anterior inferior cerebellar artery loops: 1 in the involved ear and 1 in the opposite ear. A case with bilateral tinnitus had an anterior inferior cerebellar artery loop in 1 ear. There were 29 cases of vertigo with no peripheral histopathological correlate or central nervous system disorder; anterior inferior cerebellar artery loops were found in the internal auditory canals of 7 (12.5%) of the 56 ears in this group, which is not significantly different from the 12.3% incidence recorded for the entire collection. In 23 cases of unilateral Meniere's disease, there were anterior inferior cerebellar artery loops in the hydropic ears in 3, the opposite ear in 1, and both ears in 1. We can find no correlation between unexplained hearing loss, tinnitus, vertigo, or Meniere's disease and the presence of the anterior inferior cerebellar artery in the internal auditory canal.

Adult↗
PubMed1991

Glucose uptake, perfusion, and cell proliferation in head and neck tumors: relation of positron emission tomography to flow cytometry.

The uptake of 18F-Deoxyglucose (FDG) was studied in vivo in relation to the proliferation rate of human head and neck tumors. Forty-two patients with histologically proven squamous-cell carcinoma of the head and neck and four patients with metastases of head and neck tumors were examined with PET and FDG prior to surgery. In 35 of these patients, a flow cytometric analysis of the DNA content and the proliferation rate was done using one-dimensional flow cytometry rate was done using one-dimensional flow cytometry (DAPI staining). In 17 cases, perfusion studies with 15O-labeled water were performed. Twenty-seven specimens were evaluable by flow cytometry. The analysis of the distribution of the FDG uptake revealed two groups, showing a high and a lower uptake pattern. In both groups the FDG uptake and the proliferation rate were correlated with an r-value of 0.64 and 0.8 respectively. However, the slope of the regression function was flat. No correlation was found between the perfusion and the proliferation rate. It is suggested that these differences in uptake in histologically identical tumor populations may correspond to differences at the molecular level, e.g., differences in the amount of the glucose carrier, perhaps caused by oncogenic transformation.

Carcinoma, Squamous Cell↗
PubMed1990

Morphometric analysis of normal human spiral ganglion cells.

A morphometric analysis of the human spiral ganglion was performed at an ultrastructural level. Cells of the basal, middle, and upper middle turns were evaluated by serial section. The following parameters were evaluated: myelinization, area, diameter, circumference, and degree of roundness of the cell body and nucleus; diameter of the axon and dendrite in their initial segments; and process configuration. Analysis of variance suggested there were at least two types of cell bodies within the human spiral ganglion, best delineated by the dimensions of the cell body and nucleus and the ratio of diameter of the initial segments of axonic and dendritic processes. Myelinization and degree of roundness were relatively unimportant differential parameters. Cluster (multivariate) analysis of the six most important differential parameters suggested the possibility of five subgroups among the groups of large and small cells. For the middle and upper middle turns, cluster analysis suggested that there may be as many as three groups of cells based on morphometric analysis. These results are discussed in relation to other morphologic and physiologic data in the mammalian spiral ganglion.

Adult↗
PubMed1990

[Fine needle biopsy in diagnosis of cervical lymph node changes].

In this study the validity and specificity of fine needle aspiration biopsy in cervical lymph node disease was examined. From 1983 to 1989, 495 outpatients were subjected to fine needle aspiration biopsies. One hundred and seven of the smears were not usable due to insufficient material. Tumour cells were found in 124 of the remaining 388 smears. In 117 of these cases the cytological findings were confirmed by later histology or clinical history. In the 7 remaining cases the cytological diagnosis of malignant lymphoma was disproved by histology. There were 38 (14%) false-negative diagnoses in 264 smears without tumour cells. In most of these cases the patient had undergone prior surgical or radiation therapy or had a malignant lymphoma. In spite of this relatively high number of false-negative results fine needle aspiration biopsy is helpful in the diagnosis of cervical lymph node disease. It must be emphasized that it is a screening method only: in the diagnosis of a tumour the method can only confirm and never disprove the clinical suspicion of malignancy.

Biopsy, Needle↗