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Biomedical subjects

C Remy

Publications and source records attributed to C Remy.

At least 37 records · Page 2Linked to original sources

[History of strabismus surgery].

The history of strabismus surgery starts from the end of the eighteenth century. The first surgical trials consisted of performing myotomies of the medial rectus. Although Taylor from Great Britain could be one of the first to be mentioned, it was Dieffenbach from Germany who accomplished the first official myotomy in 1839. He is followed by many authors as Roux, Velpeau in Paris, and Bonnet in Lyon, the latter performing tenotomy instead of myotomy. In 1849 Guerin performed muscular advancement. In 1883, de Wecker described the muscular pleating, and Blascowiczs the muscular resection. Thus, by the end of the nineteenth century, the surgical treatment of esodeviations was supported by methods aimed to weaken the medial rectus (tenotomies, myotomies) and to strengthen the lateral rectus (advancement, pleating and resection). During twentieth century, progress achieved in anesthesiology and the quality of suture material led Jameson (1922) to substitute tenotomy by muscular recession. Since then, the surgery of squint has never been modified basically up to 1970 when Cuppers created the retro-equatorial myopexy. Thus, two kinds of surgical technics are currently available to surgeons: classic surgery, recession, resection and their variants, dealing with the static component of the deviation angle, and the Faden Operation of Cuppers struggling against the dynamic or innervational component.

Adult

Effect of sodium benzoate on the cutaneous bilirubin content of the adult Gunn rat.

Na benzoate, which dissociates intravascular bilirubin-albumin complexes, might thus have the potential for driving bilirubin from the plasma into tissues such as the skin. We investigated this hypothesis in the adult Gunn rat. As others, we observed an early fall in blood bilirubin concentration after intraperitoneal Na benzoate injection, without any change in skin bilirubin content. Nevertheless, we observed a significant decrease (p less than 0.01) in skin bilirubin content at 24 and then 48 h after Na benzoate injection, at which times blood bilirubin remained at a low level. The phenomenon was reversible since, at 8 days after Na benzoate injection, blood and skin bilirubin contents had returned to control values. Regarding the decrease in skin bilirubin content after Na benzoate injection we described a dose-effect relationship. So, we could not confirm our hypothesis. We concluded that the phenomenon we observed is probably due to a shift in the distribution equilibrium of the pigment between serum, skin and other tissues.

Animals

[Frequency and semeiological evolution of epileptic seizures occurring between 40 and 65 years of age (author's transl)].

458 patients who had their first epileptic fit between the ages of 40 and 65 are classified into 5 groups according to the seizure symptomatology: when the symptomatology remains unchanged, the frequency of fits is less than 1 per month in 84% of generalized fits and more than 1 per month in 52% of focal fits. When the symptomatology changes, the frequency of fits is less than 1 per month when the inaugural fit is generalized (23 out of 27) and more than 1 per month when the inaugural fit is focal (15 out of 21). Modifications of the symptomatology correlate positively with a prevalence of tumor aetiology. Primary generalized epilepsies are rare (4.4%). Non-specific secondary generalized epilepsies (including vascular, metabolic or toxic encephalopathies) account for 24.4% of the cases. Focal epilepsies are the most common form (40.7%), elementary fits being four times more frequent than complex fits.

Adult

Serum digoxin levels in patients of a general practice in Germany.

Serum digoxin levels were determined in 33 outpatients of a general practice in the countryside, on three occasions at intervals of 8 weeks. All the patients were on long term digoxin treatment, about 2 years on average. About 14 days after the first and the second visits the results of the measurements were sent to the patients, with a comment about their reliability in taking treatment according to the serum digoxin level. At the first visit half of the serum digoxin level were lower than 0.5 ng/ml; the mean serum concentration was 0.52 ng/ml. There was no correlation between serum concentration and age, dose or creatinine level; but there was with replies to the question about regularity of drug intake. The mean serum level at the second and the third visits was 0.88 ng/ml and 0.89 ng/ml, respectively. A correlation was found between the dose and the serum digoxin level. From these results it seems that compliance by the patient plays a major role in producing steady state levels of drugs.

Aged

Two-dimensional 1H spectroscopic imaging for evaluating the local metabolic response to focal ischemia in the conscious rat.

Two-dimensional 1H spectroscopic imaging and magnetic resonance imaging were used to study focal ischemia induced by middle cerebral artery occlusion in rats. A water suppressing spin-echo sequence was used at 4.7 T. Phase encoding during the spin-echo delay (TE = 272 ms) yielded an 8 x 8 array of 35 microL voxels. The injured area of the brain had a higher lactate level and markedly lower N-acetyl aspartate, creatine and choline levels than did the non-ischemic regions. The spectroscopic imaging data clearly showed the localization of the infarct, which agreed well with both magnetic resonance imaging and the histological data obtained post-mortem. This study demonstrates the potential usefulness of combining magnetic resonance imaging and 1H spectroscopic imaging for studying animal models of stroke, and indicates the suitability of the technique for further pharmacological approaches.

Animals

Intrarectal diazepam in epileptic adults.

Intrarectally (i.r.) administered diazepam (DZP) solution at doses of 20 and 30 mg in the treatment of serial seizures was studied in 39 adult patients with refractory partial epilepsy. Patients were randomly distributed into two groups (20 mg, n = 21; 30 mg, n = 18). Plasma levels of DZP were assessed over 24 h following i.r. injection. The efficacy of i.r. DZP in the treatment of serial seizures in adults was confirmed; onset of effect was noted approximately 10 min after the injection, and the effective dose was 0.50 mg/kg. Tolerance and acceptability were good. Intrarectal injection of DZP can be performed even by unskilled personnel and may be recommended in patients with serial seizures in the hope of preventing development of status epilepticus.

Administration, Rectal