[Massive proteinuria associated with chronic pyelonephritis, vesicoureteral reflux and renal tuberculosis].
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to C Requesens.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
We describe a familial, relapsing type of hemolytic uremic syndrome (HUS) that has a possible genetic origin. Three members of a family, aged between 15 months and 34 years, evidenced HUS. Histological examination disclosed thrombotic microangiopathy. Recurrences, persistent hypocomplementemia, and the HLA haplotype A3,B7 were a common factor. We studied 17 members of this family and found a low C3 level from activation of the alternative pathway in the haplotype A3,B7 carriers. These three patients with HUS probably had a congenital and hereditary condition in which immunologic factors played a role in its pathogenesis.
Explore the source record for details and available documents.