[Cutaneous Paget's disease and adenocarcinoma].
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Biomedical subjects
Publications and source records attributed to C Rey-Joly Barroso.
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Baseline and evening serum myoglobin levels have been measured in 14 patients with Steinert's myotonic dystrophy. Mean levels in the morning and after a day of habitual activities, were higher in the study group than in a control group of healthy males. Serum levels in dystrophic patients were higher in the evening determinations, especially in the working patient subgroup. It is concluded that the daily physical effort of a normal job, significantly increases the serum myoglobin levels in patients with Steinert's disease.
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In a prospective study we evaluated myoglobin (MG) and serum creatine kinase (CK) levels in two groups of subjects different in age and carrier status. CK and MG values were significantly lower in the older group. Whereas both parameters fully coincided in the younger group, CK was detected in a higher number of carriers in the older group. MG was always kept within the limits of normality when CK values were normal. We conclude that simultaneous determination of CK and MG does not improve carrier detection rate, the behavior of both biological parameters is similar in the younger age, and CK is more effective than MG for this purpose in the older subjects.
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One hundred and sixteen patients with proximal deep venous thrombosis (DVT) confirmed venographically had perfusion and ventilation lung scans performed 48 hours after admission to assess the incidence of asymptomatic pulmonary embolism (PE). Sixty-six patients had normal lung scans, 29 had high-probability defects suggestive of PE, and 21 had indeterminate-probability of PE. Chest X-ray, electrocardiogram and arterial blood gases were of no value in assessing the lung scan results. Six out of 29 patients with a baseline lung scan of high probability of PE experienced acute signs and/or symptoms suggestive of pulmonary embolism while on heparin therapy. A repeated scan this time did not disclose new perfusion defects in any patients. In the absence of a baseline study, these scans may be interpreted as demonstrating pulmonary embolism on treatment and lead to unnecessary caval interruption procedures for failed heparin therapy.