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C Robles

Publications and source records attributed to C Robles.

38 records · Page 3Linked to original sources
PubMedDate not supplied

[MHC-dependent molecular mechanisms of susceptibility and protection in type I diabetes in Mexicans].

MHC class II genes play an important role in the autoimmune destruction of the pancreatic b-cell occurring in IDDM. The genetic pattern of the disease was investigated in Mexican Mestizos. The serological findings of HLA antigens showed a significant association of DR3, DR4, DQ2 and DQ8 and a protective effect of DR11, DR15, DQ5, DQ6 and DQ7. With these results, DNA analysis of HLA-DRB1, B3, B4, DQA1, DQB1, DPA1, DPB1 genes was performed using PCR with allele specific oligotyping. Among the patients, 92.78 carry DQA1 alleles that have ARG in position 52 of DQa chain, and 78.2% are ASP- in DQ5-57. The RR for homozygotes is 32.8 and 5.6, respectively. The main haplotype involved is DRB1*0405, DQA1*0301, DQB1*0302. Thus, DQa and DQb form a relevant recognition site for the "diabetogenic peptidett which induces the autoimmune destruction. Positions 57 and 74 of DRB1 locus contribute highly to the expression and severity of IDDM in Mestizos and other ethnic groups, but not in Caucasians or Blacks.

Adolescent↗
PubMedDate not supplied

[The chemotherapy of cysticercosis. The results 10 years or more after follow-up].

Chemotherapy for neurocysticercosis was born logically because of the scant success of surgery, which is generally palliative, not curative. Prazicuantel is the only drug about which serious of more than 100 cases, and follow-up of more than 2 years, have been published. Its use has become universal, reason enough for this theme to be addressed. This paper pretends to contribute to the determination of its therapeutic value in the treatment of neurocysticercosis by means of the clinical and radiologic treatment of 50 sick persons followed up for from between 10 (72%) and more than 10 (28%) years. The patients had been treated with prazicuantel with a dose of 50 mg per kilo of body weight during 15 days; 26% received one treatment, 58% received two, and 22%, three or more treatments. The patients were studied once again clinically and radiologically with computed axial tomography of the cranium and magnetic resonance. Biological testing was done only if activity-suspected cases. The results showed a rate of 68% clinical cures or important improvement. Emphasis is made of the 6% of cases in which the clinical cure process was apparent. It was confirmed that neurocysticercosis is a generalized chronic ailment in which evolution is achieved by means of periods of activity alternating with periods of recession. The employment of witnesses is not advised, and it is suggested for later investigation that ample series of cases be followed-up over long periods of time. It is insisted upon that the best treatment for the illness is prophylaxis.

Adolescent↗