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Biomedical subjects

C Rodríguez Sánchez

Publications and source records attributed to C Rodríguez Sánchez.

7 recordsLinked to original sources

Ultrastructural study of neuromuscular junction in rectus femoris muscle of streptozotocin-diabetic rats.

The neuromuscular junctions (NMJ) from rectus femoris muscle in streptozotocin (STZ)-induced diabetic rats were examined by electron microscopy eight weeks after the STZ injection. When compared to controls and vehicle-injected groups, both the axon terminal and the junctional sarcoplasm showed serious alterations including mitochondrial degeneration, presence of myeloid bodies, breakdown of presynaptic membrane and changes in the form of the synaptic vesicles. The results suggest that NMJ can contribute to the pathogenesis of diabetic proximal myopathy.

Animals↗

[Chronic hepatitis caused by B virus and glomerulonephritis in children].

Eight children with chronic HBV hepatitis and glomerular disease were studied. There were seven males and one female, with ages between one and nine years old. Three had CPH and five CAH. All patients with CPH had membranous nephropathy, and those with CAH three had MNG. one membranoproliferative glomerulonephritis and one mesangial glomerulonephritis. Only six patients had moderate liver enlargement. In all, the diagnosis of HBV infection was performed by investigation of the etiology of their nephropathy. Liver function test showed signs of moderate necrobiosis with impaired biliary acid metabolism. All were HBsAg (+), antiHBc (+), six were antiHBe (+) and two were HBeAg (+). In one case renal deposit of HBsAg was found. Due to the frequent association of HBsAg and glomerulonephritis (GN) in children, an investigation of liver function is highly recommended in those patients with GN a HBV infection.

Child↗

[Choledochal cyst. Presentation of 5 cases in childhood].

Five cases of choledochal cyst diagnosed from 1976 to 1983 are presented. Four patients began in the neonatal period as a cholestatic syndrome resembling biliary atresia and one patient began later on as a cholangitis. It is important for diagnosis the use of ultrasounds and radionuclide hepatobiliary. Clinical course depends on early diagnosis and treatment, because there is often an atresia of the common hepatic duct associated.

Bile Ducts↗

[Desquamative interstitial pneumonia].

Authors describe a case of desquamative interstitial pneumonia in a seven month old boy. Initial manifestations were anorexia, feeding difficulties, retarded ponderal and progressive respiratory distress. Pathologic diagnosis was performed by open pulmonary biopsy. He was treated with steroids and followed a severe clinical course dying at 9 months of age. Etiopathogenesis, diagnosis and treatment as well as cases published in pediatric literature are reviewed.

Humans↗