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Biomedical subjects

C Rodríguez

Publications and source records attributed to C Rodríguez.

At least 217 records · Page 12Linked to original sources
PubMed1986

[Usefulness of cerebral computed axial tomography in the early diagnosis of tuberous sclerosis].

Authors describe twelve children with diagnosis of tuberous sclerosis (TS) within the first year. All children had seizures, being infantile spasms in 7 cases (58%). All but one showed severe mental retardation. Hypopigmented patches in 2 (16.6%) and retinal phakoma in one case (8.3%). Skull Rx were normal in all cases, while the CT showed early intracranial calcifications in the 100% of the patients and areas of hypodensity in the 50%. The CT is the most useful test for the early diagnosis of TS when the clinical diagnosis has not been firmly established.

Evaluation Studies as Topic↗
PubMed1986

Comparison of the inhibitory effect of three antimuscarinic drugs: pirenzepine, atropine and propantheline on acid secretion and gastric emptying in the conscious rat.

The present investigation was carried out to compare the effects of pirenzepine, a novel antimuscarinic drug, with those elicited by atropine and propantheline on gastric acid secretion and gastric emptying in the conscious rat. The administration of all three drugs resulted in a dose-related inhibition on both parameters that at large doses was nearly total. Comparison of the ID50 ratios for each antagonist on gastric emptying versus acid secretion showed that pirenzepine was unique in that it selectively inhibited acid secretion. Its potency on acid secretion was about 15 times higher than that elicited on gastric emptying. The results are compatible with the proposed existence of two different classes of gastric muscarinic receptors mediating secretory and motor activities.

Animals↗
PubMed1985

Glycemia, ketonemia, and brain enzymes of ketone body utilization in suckling and adult rats undernourished from intrauterine life.

The effect of undernutrition from the 16th day of pregnancy up to 70th day of life on blood glucose and ketone bodies and on several brain mitochondrial enzymes related to energy metabolism or biosynthetic function was investigated. Undernutrition in perinatal period was established by means of a food restriction to pregnant rats and, later, to the lactating mother; undernourished postweaned rats received half the diet consumed by the controls. Body and brain weight from undernourished rats was less than controls throughout the entire period studied. Glycemia and ketonemia were also always lower than controls. Cytochrome c oxidase, citrate synthase, 3-hydroxybutyrate dehydrogenase, 3-oxoacid coenzyme A transferase, and acetoacetyl-coenzyme A thiolase activities during the suckling period were in most stages lower than controls; subsequently, activities in undernourished rats reached or surpassed the control values. These results could explain the "catch up" phenomenon in several ultrastructural parameters found by other authors in undernourished postweaned rats.

Animals↗
PubMed1982

[Liver glycogen, blood glucose, somatotropic hormone, and hypophyseal thyrotropin in neonatal rats treated with cortisol and in malnourished ones].

A population of rats treated with a single dose of cortisol on their first day of life and a population of rats underfed since day sixteen of gestation until sacrificed have been studied. Body, brain and liver glycogen content have been measured at eight, twelve and twenty-two days of life and compared to controls of the same age. Pituitary growth hormone and thyrotrophin content have also been measured in the same population of animals and at the same stages of life. Results are compared to those found in "neo-T4" rats -- which receive 30 micrograms T4 in 5 doses during the first days of life -- at the same ages.

Animals↗