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Biomedical subjects

C Rodriguez

Publications and source records attributed to C Rodriguez.

At least 109 records · Page 6Linked to original sources
PubMed1985

Influence of hormones and undernutrition on brain development in newborn rats.

High L-thyroxine (T4) and cortisol doses given to rats during the first 8 days of life and on the first day only respectively, produce decrease of body and brain weight and perturbances to brain energy substrates, i.e. glucose and ketone bodies. The same alterations are found in the undernourished rats from the prenatal period. The pituitary GH and TSH is decreased in the T4- and cortisol-injected animals. The plasma ACTH is decreased in the treated cortisol animals at 8, 12 and 22 days of life. The pituitary TSH content is reduced with respect to controls in the undernourished animals from 14 to 70 days of life. From the exposed experiments we suggest an alteration in the hypothalamic-pituitary complex in T4- and cortisol-treated rats, and describe the similarities between the three experimental models.

Aging↗
PubMed1984

Different monoclonal antibodies against the component 5 specific for Trypanosoma cruzi.

Three murine monoclonal antibodies (I-35/67, II-190/30, III-160/18) produced by immunization against total epimastigote extract or component 5-enriched fractions of Trypanosoma cruzi (Tehuantepec strain) have been demonstrated to recognize the component 5 specific for T. cruzi. By immunofluorescence studies, one of these monoclonal antibodies (I-35/67) was shown to bind to the epimastigote cell surface, and the two others (II-190/30 III-160/18) were preferentially directed against internal subcellular organelles. Immunoprecipitation using these monoclonal antibodies followed by SDS-PAGE analysis, has led to identification of four molecules with apparent molecular weights of 72 Kd, 51 Kd, 43 Kd, and 24 Kd in T. cruzi epimastigotes. Potential uses of these monoclonal antibodies in serological tests and immunochemical analysis of target antigens are discussed.

Animals↗
PubMed1983

'Osmosin' in rheumatoid arthritis: interim results.

The interim results of an on-going trial in patients with active rheumatoid arthritis are reported. The findings from 17 patients so far treated and followed-up for 4 to 6 weeks suggest that 'Osmosin' (105 mg sodium indomethacin trihydrate), given once daily for the first 2 weeks and twice daily thereafter, is effective in reducing the inflammatory activity of joint disease, as assessed by visual analogue and 5-point semantic severity scales. Analysis showed that there was a strong association between the assessments on the two scales and this was stronger if patients were not conditioned by being allowed to see their previous visual analogue scale assessment.

Arthritis, Rheumatoid↗
PubMed1983

Testing of two score systems for the diagnosis of malnutrition.

Two score systems, one for the diagnosis of obesity and another for diagnosing undernutrition were tested in thirteen overweight and seven underweight children aged five years and preliminarily classified as malnourished. These score-systems included indicators grouped into three categories, those which evaluate total body mass changes (one-point group); those which assess fatness (two-point group); and those which assess fatness and/or body composition through complex indices (three-point group). Indicators such as Energy/Protein Index, AKS Index, Somatotype ratings, and Somatotype Dispersion Distances were included in the third group and played an important role in the final score. A subject was classified as malnourished if he reached 80% of the maximum possible score. According to these criteria, only six among the thirteen overweight children could be considered obese and none of the seven underweight ones could be classified as undernourished. Mild or moderate overweight or underweight may be misleading and an incorrect diagnosis of either obesity or undernutrition can be made if the possibility of constitutional corpulence or thinness is not taken into account.

Anthropometry↗
PubMed1982

[Production of monoclonal antibody anti-antigen 5 for Trypanosoma cruzi].

Monoclonal antibodies against Trypanosoma cruzi have been produced by fusion of Sp 2/0 myeloma cells and splenic lymphocytes from BALB/c Mice immunized with a T. cruzi antigenic fraction. Antigenic studies of these monoclonal antibodies have led to the identification of IgG 1 antibody against the component 5 specific for T. cruzi (cellular clone II 190/151). These monoclonal antibodies will give rise not only to new diagnostic and epidemiological perspectives but will also aid in achieving a better understanding of the biological role of this antigen.

Animals↗
PubMed1982

Total and cell wall phosphorus content in Bacillus megaterium in phosphate-limited media.

A comparative study of the amount of total and cell wall phosphorus in Bacillus megaterium ATCC 33085, grown in media with or without phosphate limitation was carried out. The phosphorus levels were investigated during six successive subcultures. A progressive decrease in total phosphorus was found in cells cultivated in a phosphate-limited medium. A decline in the cell wall phosphorus level was observed starting only from the third subculture in phosphate-limited medium, and no phosphorus was detected in the walls of cells in the fifth subculture.

Agar↗
PubMed1982

Assessing obesity with body weight and height.

Anthropometric measurements in one hundred girls and one hundred boys from 4.6 to 5.5 years of age were carried out in order to study the correspondence between the criteria of obesity according to weight for stature (BW-HT) and according to the magnitude of fat body mass (FM calculated of two different regression equations, one developed starting from body weight (BW), height (HT) and two skinfolds, and another one, using only BW and HT. Employing the criterion of obesity based upon BW-HT above 120%, a number of heavy but not fatty subjects (mainly boys) were included as obese, and three of the girls studied were fatty but not overweight. Conversely, if we calculate FM using the regression equation based on BW and HT, and the criterion of obesity based upon body fat percent, the incidence of obesity could be underestimated. The best results were given by regression equations which include BW, HT and two skinfolds (triceps and subscapular). Though the usefulness of BW and HT in nutritional assessment is not discussed, the diagnostic limitations of these measurements used alone or in combination are evident and therefore it is necessary to include skinfold measurements if we wish to obtain a correct diagnosis of obesity.

Adipose Tissue↗
PubMed1982

Rapid learning of visual and auditory spatial task in binocularly deprived cats.

Visually deprived and non-deprived cats were trained in a task involving a directional alimentary response spatially contiguous with a visual or an auditory cue. Both visual and auditory tasks were learned much faster by deprived cats. In these cats targeting reflexes evoked by the cues were stronger. When the modality of the cue was changed (from visual into auditory or vice versa), the learning was rapid in both non-deprived and deprived cats.

Animals↗
PubMed1979

Anaprox in dysmenorrhea: reduction of pain and intrauterine pressure.

In a double-blind parallel trial, 24 dysmenorrheic women received a single dose of Anaprox (1,100 mg) or placebo. Over the next 2 hours, pain intensity was scored and intrauterine pressure was measured using an immobilized microballoon. At the end of 2 hours, all 11 patients given Anaprox (but only three of the 13 given placebo) experienced complete pain relief (p = 0.0004). The resting intrauterine pressure (IUP) decreased from a mean of 51.4 to 26.8 mm Hg in the Anaprox-treated group, while in the placebo group the mean resting IUP values remained essentially unchanged ( drop from 55.4 to 51.9 mm Hg was observed). This difference between the two treatment groups was statistically significant in favor of Anaprox (p = 0.03). Several patients from each group were given 0.2 mg of ergonovine by intramuscular injection following the 2 hour trial. In both groups, the resting IUP increased within 30 minutes; the corresponding increase in pain intensity was more pronounced, however, in the placebo group. These results support the premise that a decrease in resting IUP is directly linked to the pain-relieving effects of Anaprox.

Adolescent↗
PubMed1979

Purification and partial characterization of an antibiotic produced by Myxococcus coralloides.

A strain of Myxococcus coralloides producing an antibiotic capable of inhibiting growth of Gram-positive bacteria was isolated. Antibiotic production occurred during vegetative growth but not during myxospore formation. The antibiotic was extracted from the growth medium with chloroform and purified by adsorption on silicic acid and by preparative silica gel thin-layer chromatography. The purified antibiotic showed a resistance to heat, acid, alkali and proteolytic enzymes. Chromatographic and electrophoretic behavior as well as infrared, ultraviolet and mass spectra are presented.

Anti-Bacterial Agents↗