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Biomedical subjects

C Romaguera

Publications and source records attributed to C Romaguera.

At least 19 recordsLinked to original sources
PubMed1992

Human irritant response to different qualities and concentrations of cocoamidopropylbetaines: a possible model of paradoxical irritant response.

Cocoamidopropylbetaines are surfactants frequently used in cosmetics. We have evaluated the irritant capacity of 3 different qualities of cocoamidopropylbetaine, using the following method: patch tests have been carried out with 5 different dilutions in 67 patients and the results read at 2 days by noninvasive methods (direct visualization, transepidermal water loss (TEWL), laser Doppler flowmetry (LDF)). The results with the 3 methods were concordant. However, the results with the different concentrations were paradoxical, as irritancy did not increase at higher concentrations. We have tried to explain this by the fact that these substances contain by-products (free amidoamine and sodium monochloroacetate), the concentrations tested all being above the critical micelle concentration and therefore containing both micelles and monomer. Finally, we believe that noninvasive methods such as TEWL and LDF could be of great use in the evaluation of irritant contact dermatitis.

Adult↗
PubMed1992

Occupational and non-occupational allergic contact dermatitis from beryllium.

There are various references to sensitization to beryllium in the literature. Since introducing a patch testing series for patients with suspected sensitization to metals, we have found 3 cases of sensitization to beryllium. Of these 3 cases, we regard the first 2 as having relevant sensitization. Beryllium chloride (1% pet.) was positive in 3 patients and negative in 150 controls.

Adult↗
PubMed1992

Study on the sensitizing capacity of the new antimycotic sertaconazole in the treatment of cutaneous mycoses.

The sensitizing capacity of 7-chloro-3-[1-(2,4-dichlorophenyl)-2- (1H-imidazol-1-yl)ethoxy-methyl]benzo[b]thiophene (sertaconazole, FI-7045, CAS 99592-32-2) was studied in a randomized double-blind clinical trial in 78 atopical volunteers of both sexes. Sertaconazole in 2% dermatological cream form was compared with 5 other commercially available antimycotics (econazole, ketoconazole, bifonazole, clotrimazole and miconazole), using the excipient of the cream without sertaconazole and 2% sertaconazole in vaseline as controls. At the end of the trial, only miconazole showed a positive allergy (vesiculation) in two of the 78 individuals studied. The other substances did not demonstrate any sensitizing capacity, including sertaconazole and its excipient. This trial showed that sertaconazole in 2% dermatological cream form does not possess a sensitizing capacity for causing contact dermatitis which confirmed its excellent safety in topical use.

Adolescent↗
PubMed1991

New trends in the use of metals in jewellery.

Owing, on the one hand, to the constant increase in the %s of nickel sensitization in the majority of allergy departments of dermatology and, on the other, to the fact that sensitization to nickel is almost always through contact with jewellery and imitation jewellery, an update was carried out on the metal alloys principally used in the manufacture of such jewellery (earrings, bracelets, necklaces, rings, watch straps, etc.) The conclusions of this review demonstrate that nickel is irreplaceable in the majority of the alloys, because of its excellent technical properties and low price and, as a result, the % of sensitizations to this allergen will not only maintain their present high level but will probably increase in the future.

Alloys↗