PubMed Health⌕ Search

Biomedical subjects

C Roques

Publications and source records attributed to C Roques.

46 records · Page 3Linked to original sources
PubMed1991

Effect of an in vivo immunostimulant treatment on PMN functions: interaction with antibiotics in vitro.

The in vivo effect of immunostimulant treatment, bacterial ribosomes together with membranal proteoglycans (three tablets and three sprays daily during 4 days) in combination or not with in vitro amoxicillin or josamycin (range 5-50 micrograms/ml), has been studied on three related functions of polymorphonuclear cells (PMN) isolated from human blood: adhesion, spontaneous and oriented migration. The immunostimulant treatment always induces an increase of the three parameters. A positive effect of high concentrations of amoxicillin could be also observed on adhesion and gives rise to a great additional impact by associating it with immunostimulant treatment (control: 8.26 PMN/field; assay: 51.55 PMN/field). Spontaneous and oriented migration are not very altered by in vitro antibiotics. A very significant decrease of chemotaxis has been only observed with 50 microgram/ml of josamycin. However, the immunostimulant treatment compensates for this negative effect. The real increase in PMN activation produced by the immunostimulant treatment might extend its indications beyond prevention during antibiotherapy, for example in the acute phase of respiratory infections.

Adjuvants, Immunologic↗
PubMed1985

[A proposed protocol for prevention of congenital toxoplasmosis adaptable in a tropical zone].

In Toulouse, various epidemiological works and biological results regarding toxoplasma infection permitted us to study immunity in pregnant women. 66 to 70% are immunized. Incidence of acquired toxoplasmosis is 1 to 2 for 1,000 pregnancies. Carefully planned, regionalized programs with obstetricians and pediatricians are realized to prevent congenital toxoplasmosis. Epidemiological studies may be realized to estimate the prevalence and the incidence of congenital toxoplasmosis before such programs can be recommended on a national scale in tropical area.

Female↗
PubMedDate not supplied

Study on the production of a xylanolytic complex from Penicillium canescens 10-10c.

We screened about a hundred microorganisms (including unidentified yeasts, fungi, and bacteria) for their ability to produce xylanolytic enzymes. About 40 of them were hemicellulolytic; among these, we selected Penicillium canescens 10-10c for detailed study because of its ability to produce an interesting enzymatic complex in quantity. The xylanase complex was cellulase-free, and had an optimal activity at pH 4.6-5.0 and 55-60 degrees C on birchwood xylan. The best production was on soya meal and wheat straw; expression of the xylanase was repressed by glucose, xylose, and lactose. The optimization of culture medium and mode (fed-batch) enabled us to improve the production three to four times. The importance of the mixing conditions on the biomass and xylanase production is also reported.

Flour↗
PubMedDate not supplied

[The bactericidal activity of mouthwashes containing 0.10%, 0.12% and 0.20% chlorhexidine digluconate].

Antiseptic activity of five mouthrinses containing 0.10%, 0.12% and 0.20% chlorhexidine, as well as aqueous chlorhexidine solutions at the same concentrations were determined under usual conditions (advocated dilutions by the manufacturers and short contact time) and according to French Pharmacopoeia recommendations. The three aqueous solutions and two mouthrinses containing 0.12% chlorhexidine were not antiseptic according to the fixed criteria. Bactericidal activities of the different dilutions of products were tested with an appropriate micromethod against nine-bacterial species involved in periodontal disease. Efficacity of mouthrinses were variable and were not agreed with the aqueous chlorhexidine-corresponding solutions: the mouthrinse containing 0.10% chlorhexidine reached 0.20% aqueous solution efficacy, and the mouthrinses containing 0.12% chlorhexidine were generally less active than the 0.12% aqueous chlorhexidine solution. Therefore, antibacterial activity of this type of product cannot be anticipated with the sole concentration factor, excipients playing essential part in the chlorhexidine activity.

Anti-Bacterial Agents↗