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C Ruchti

Publications and source records attributed to C Ruchti.

72 records · Page 4Linked to original sources
PubMed1978

Morphologic and functional substrate of thyrotoxicosis caused by nodular goiters.

The pathogenesis of nonimmunogenic thyrotoxicosis caused by nodular goiters--with the exception of true toxic adenoma--was investigated in 11 patients by means of scintigraphic, morphologic and autoradiographic technics. The basic event is the appearance, for unknown reasons, of autonomously functioning follicles which are morphologically indistinguishable from normal follicles. Four basic patterns of intrathyroidal distribution of autonomously functioning follicles are individualized: Type I = multiple individual autonomously functioning follicles scattered throughout the goiter. Type II = clustered autonomous follicles without demarcation from less active parenchyma. Type III = multiple microadenomas. Type IV = autonomous function of the majority of all follicles. In all four types, the autonomous follicles occur without recognizable relation to nodule boundaries. Scintiscans cannot predict the microstructure of these types of goiters. More than one pattern of distribution of autonomously functioning follicles may occur within a single goiter. The growth of thyroid nodules is independent of, and certainly not a prerequisite to, thyrotoxicosis. Rather, the appearance of thyrotoxicosis in this type of multinodular goiter depends on (1) the number of autonomous follicles throughout the gland and (2) their mean hormone-producing capacity per unit of time.

Autoradiography↗
PubMed1977

Humoral antibodies against spermatopoietic cells associated with mediastinal germinoma.

A case of mediastinal germinoma in a 21-yr-old male is reported. The neoplasm exhibited a morphology similar to that of a testicular seminoma and was heavily infiltrated by lymphocytes and plasma cells. Germinal centres were also present in lymph follicles. Humoral antibodies (IgG), specific for spermatopoietic tissue, were present in the patient's serum. Antibody titres declined after surgical removal of the germinoma over a period of 2 yr, and antibody is no longer detectable at the present time. The implications of this observation are discussed with regard to defence mechanisms of the tumour host, and to the histogenesis of these rare neoplasms.

Adult↗
PubMed1976

[Congenital liver cysts. Case report and review of the literature].

A study is presented of four female patients with congenital solitary liver cyst. The largest cyst had a volume of 4 liters. One of the patients studied had a neoplasm which was possibly the result of secondary malignant degeneration of the cyst. Congenital cystic degeneration may develop in the entire biliary tract. The clinical symptoms depend on the size, localization and number of cysts. Characteristic signs and symptoms caused by displacement of the intestinal organs begin to appear as a rule in late adulthood. The cysts rarely impair liver function. Hemorrhage into the cysts, rupture of the cystic wall, infection or secondary malignant degeneration of the cysts, torsion and strangulation are infrequent. Solitary cysts of the liver are not accompanied by cysts in other organs as is the case in polycystic liver disease. Diagnostic procedures, differential, diagnosis and therapeutic measures are discussed, and reference is made to non-congenital cystic formations in the liver.

Aged↗
PubMed1976

[Epithelial barriers of the intestine. Significance and function in defense against infection].

The epithelial surface of the intestinal tract provides for an important barrier between the organism and its environment. However, it permits the passage into the tissues of limited amounts of macromolecules and/or particles, especially bacteria. These functions are age- and species-dependent, and they are closely related to nonspecific and specific immune reactions. Continuous and intimate contact between antigenic material from the gut lumen and immunocompetent cells takes place in gut-associated lymphoid tissues.

Bacterial Infections↗
PubMed1976

[Angiography in Crohn's regional enteritis. Its relation to conventional radiological, endoscopic and micro-angiographic findings].

There has been a definite increase in the incidence of Crohn's disease in recent years. A particular feature of this disease is the high incidence of recurrence after surgical removal of affected portions of the gut. This may be due to a resection carried out through a diseased segment and this stresses the importance of recognising early changes. This is not possible by conventional radiology (small bowel examination, barium enema) and is therefore an indication for pre-operative visceral angiography. The results obtained in ten patients, who subsequently came to surgery, were compared with the findings on conventional radiology and endoscopy. Angiography proved the best method for the early demonstration of inflammatory changes. This was confirmed by histological examination of the resected specimen.

Adult↗
PubMedDate not supplied

Biocement--a new material. Results of its experimental use for osseous repair of skull cap defects with lesions of the dura mater and liquorrhea, reconstruction of the anterior wall of the frontal sinuses and fixation of alloimplants.

A newly developed material, which we call biocement, consisting of bisphenol-a-glycidyl methacrylate ("epoxide methacrylate') as organic matrix and Bioceramic Battelle, Bioglass Hench and/or pentacalcium hydroxide triphosphate ("tri-calcium phosphate') powder as filling particles is presented. In an extension of previous experiments, various types of this biocement, containing different admixtures of particulate matter, were employed to test their usefulness in head surgery, in particular maxillo-facial reconstruction, on dogs and a rhesus monkey. Encouraging results were obtained with regard to (a) fixing a titanium alloimplant under some degree of mechanical stress; (b) covering a defect in the skull cap, including the closure of an artificially induced meningeal fistula with liquorrhea; and (c) reconstruction of defects in the anterior wall of frontal sinuses. Special emphasis is placed on direct contact between biocement and bone, interdigitations between these two, reactions of meningeal tissue, and regeneration of ciliated epithelium underneath fixed reimplants over the frontal sinus.

Acrylates↗