Biomedical subjects
Publications and source records attributed to C Runti.
After a brief introduction on the chemistry of indazoles in general, the most important clinically used drugs of this series, i.e. benzydamine, bendazac and its salts and esters, are mentioned. The possible synthetic processes for benzydamine are then reviewed and any possible occurring by-products and impurities, including their quantitative limits, are discussed.
In studies concerning the relation between structure and sweetness in sulfamic acid derivatives, two new sweeteners (VI) and (VIII) were found. Their corresponding sulfochlorides are also unexpectedly sweet-tasting.
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The synthesis and pharmacological activity of several adamantane derivatives and analogs of tilorone are described as part of a systematic research on potential antiviral compounds and/or interferon inducers.
Several derivatives of L-acylamidosuccinanilic acids have been prepared inorder to study the relationship between the chemical structure and the sweetening activity by modifying the amino or the acylamido portions of the molecule. Some synthesized compounds possess a pronounced sweet taste, the L-4'-nitro-(2,2,2-trichloroacetamido)succinanilic acid is the most outstanding compound, being approximately 3000-4500 times as sweet as sucrose.
Adamantane isologs of amphetamine, methamphetamine and pheniprazine and several derivatives were synthesized in order to study the influence of their more pronounced lipophilic characteristics on their biological properties. A preliminary examination of their toxicity, antiviral, CNS stimulant and antiparkinson activity is described. The adamantyl amphetamine, which proved active, will be further studied.
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