Biomedical subjects

C Ryom

Publications and source records attributed to C Ryom.

4 recordsLinked to original sources

PubMed1992

Recovery following thiopentone or propofol anaesthesia assessed by computerized coordination measurements.

Quantitative measurements of coordination ability and performance speed were carried out on 76 female day-case patients undergoing minor gynaecological operations. The women were assigned at random to the anaesthetic agent used, propofol 2.5 mg/kg or thiopentone 4 mg/kg. Spacing control, timing control and performance speed were recorded using a newly developed computerized coordination ability test system. The patients were tested once before the operation and 0.5, 1 and 2 h after awakening. Postoperatively the initial impairment and the subsequent regression towards preoperative test results were very similar whether the anaesthetic agent was propofol or thiopentone. Although the test apparatus was able to detect even minor differences, no postoperative test showed statistically significant differences between the two groups. We find it reasonable to conclude that there is no difference in recovery of coordination ability following propofol- or thiopentone-induced anaesthesia.

Adolescent↗

PubMed1990

Computerized coordination ability testing.

Quantitative measurements of coordination ability were carried out on 76 women with a median age of 37, range 15 to 60. Spacing control, timing control and performance speed were recorded using newly developed computerized equipment, Catsys, presented in this paper. Twenty-three subjects were re-examined 2-3 months after the first measurements. A fair or even high degree of reproducibility of tests was found. Normal values for the entire group and correlation values for the re-examined group are presented. The results from this small study implies that the Catsys may be useful, e.g., in future clinical neurological practice of diagnostics and follow up on patients, in occupational medicine for detection of neurotoxic effects of various neurotoxic substances, in evaluation of drug effects and side effects and for testing people in occupations where normal coordination skills are absolutely necessary.

Adult↗

PubMed1989

Chorioangioma placentae and feto-maternal transfusion; a report of two cases.

Chorioangioma (CA) is found in about 1% of all placentas. Here we report cases of CA: one associated with intra-uterine fetal death, and the other with feto-maternal transfusion resulting in severe anaemia of the child. Feto-maternal transfusion through a CA could, in suspected cases, be diagnosed by s-AFP, one-minute alkali-denaturation test and perhaps ultrasound of the placenta. Intra-uterine death of the child could then be prevented by Caesarean section.

Adult↗

PubMed1986

A strain-gauge myograph for isometric measurements of tension in isolated small blood vessels and other muscle preparations.

Isometric tension measurements in vitro on small vessels are important in studies of pharmacodynamic vascular effects of drugs and autacoids. The present study describes a precision myograph equipped with a newly constructed highly isometric strain-gauge transducer used in conjunction with a very sensitive, low-noise and virtually drift-free dc-amplifier. The isometric quotient of the transducer, defined as deflection in micrometer per g of force, is about 5.2. The transducer resonance frequency is 341 c/sec with a damping constant of 1.05. The highest sensitivity of the transducer in connection with the matching dc-amplifier is about 170 mV/V/g force. The practical working range of the myograph is from 2 mg to about 10 g of applied tensile force. Tubular segments of vessels with internal diameters down to 150 micron can be mounted in the myograph on two stainless-steel pins submerged in a 5 ml preparation bath. Precise mounting and setting of passive (resting) tension is assured by the use of micrometer-equipped adjustable miniature mounting tables suspended by roller bearings. The myograph may be provided with electrodes for field-effect stimulation of the vessel preparations. Other muscle preparations may also be mounted in the myograph. Application of the myograph in studies on rabbit coronary arteries is demonstrated by a length-tension diagram obtained in experiments with tubular segments (inner diameter about 500 micron) of the circumflex branch on the left coronary artery, which shows a typical course in development of active and passive tension of the smooth musculature when exposed to alternating potassium depolarization and increasing mechanical stretching. The potassium contracture of the coronary vessels and the log-concentration/response relationship at accumulating potassium concentrations were also investigated.

Animals↗