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Biomedical subjects

C S Devi

Publications and source records attributed to C S Devi.

At least 37 records · Page 2Linked to original sources
PubMed1990

Lipids and lipoprotein profile in doxorubicin treated rats: influence of alpha-tocopherol administration.

The effect of doxorubicin (DXR) on the levels of heart, liver and plasma lipids and plasma lipoproteins were studied in rats. Rats were treated with DXR (2.5 mg/kg body weight weekly for 8 weeks, iv) with or without alpha-tocopherol (alpha-TPL) (400 mg/kg body wt daily for 60 days) co-administration. DXR treated rats showed increase in plasma total cholesterol, triglycerides and phospholipids. The activities of lecithin cholesterol-acyl transferase and hepatic and extrahepatic lipoprotein lipase were lowered significantly with concomitant increase in liver and heart lipid peroxide levels in DXR treatment. HDL cholesterol level was found to be decreased significantly in DXR treated rats as a result of which there was an increase of LDLc/HDLc ratio. alpha-TPL coadministration brought back the enzyme activity to near normal and reduced the level of lipid peroxides. The lipid changes were minimum in rats treated with both alpha-TPL and DXR. This study suggests that the toxicity of DXR is reflected in lipids and lipoprotein profile.

Animals↗
PubMed1989

Effect of alpha-tocopherol on peroxidative membrane damage caused by doxorubicin: an in vitro study in human erythrocytes.

Level of lipid peroxidation in doxorubicin treated human erythrocytes was studied and compared with that of cells pretreated with alpha-tocopherol. Erythrocytes treated with alpha-tocopherol had reduced level of lipid peroxidation with concomitantly lowered membrane damage. The membrane damage was monitored by the levels of conjugated diene absorption, lipid hydroperoxides and lipid peroxides. alpha-tocopherol was not effective in inhibiting the conjugated diene formation, but the lipid hydroperoxides and the lipid peroxide levels were significantly decreased. Methemoglobin level was found to be increased in alpha-tocopherol pretreated cells, which protects the membrane from damage. Erythrocyte membrane lipids were found to be decreased during doxorubicin treatment and alpha-tocopherol significantly reduced the membrane lipid breakdown. Level of reduced glutathione was maintained in alpha-tocopherol pretreated cells. These results are discussed with reference to the antioxidant property of alpha-tocopherol.

Cells, Cultured↗
PubMed1982

Concentration of triglyceride and cholesterol in lipoprotein fractions in maternal and cord blood samples.

Blood samples from 100 normal mothers at delivery and from umbilical cord blood were analysed for total cholesterol, triglyceride and cholesterol in high density lipoprotein. Cholesterol in very low density lipoprotein and low density lipoprotein were calculated by formula. Electrophoresis in agarose gel was performed on serum. There was no significant difference in the values in cord blood of girls and boys. There was no significant correlation between maternal and cord blood values. Pre-beta band was present in all cord blood samples. The electrophoretic mobility of pre-beta in cord blood is the same as that in adult blood. Faster mobility of alpha is observed in 26% of the cord blood samples.

Cholesterol↗
PubMed1977

Tinidazole and metronidazole in the treatment of intestinal amoebiasis.

Sixty adult patients with symptomatic intestinal amoebiasis and with Entamoeba histolytica present in stools were allocated at random to treatment with tinidazole or metronidazole, both administered in a dose of 2 g once daily for 3 consecutive days. The treatment period was extended in patients with stools positive for Entamoeba histolytica on the day following the last treatment day. Fifty-six patients, 29 on tinidazole and 27 on metronidazole, completed the trial as per the protocol. Twenty-eight patients (96.5%) on tinidazole and 15 (55.5%) on metronidazole were cured. Parasitological cure with partial relief of symptoms was obtained in 1 (3.5%) and 5 (18.5%) patients on tinidazole and metronidazole, respectively. Seven patients (26%) on metronidazole were treatment failures. Treatment had to be extended beyond 3 day in 53% of patients (8/15) on metronidazole as opposed to 11% (3/28) on tinidazole (p less than 0.01). The total number of side-effects, their severity, and the types were more in the metronidazole group. No toxic effects due to either drug were recorded. Tinidazole provided significantly higher cure rates than metronidazole in the treatment of symptomatic intestinal amoebiasis (p less than 0.01), and was better tolerated than metronidazole.

Adult↗
PubMed1976

Plasma lipids and lipoproteins in protein-calorie malnutrition.

Plasma triglycerides, phospholipids and total cholesterol estimations and lipoprotein electrophoresis on agarose gel were done in control, Kwashiorkor, and marasmic kwashiorkor children. The beta lipoprotein percentage in both conditions is reduced to a statistically significant extent, whereas there is a statistically significant increase in plasma triglycerides in both conditions. Pre-beta fraction was present in all cases, and even increased in marasmic kwashiorkor, which is found to be significant. The results do not support the hypothesis that fatty liver in kwashiorkor is due to impaired release of triglycerides from liver.

Child, Preschool↗
PubMed1976

Serum lipoprotein profile in infectious hepatitis.

There is absence of pre-beta and alpha-lipoproteins in the acute stage of infectious hepatitis. With improvement both clinically and biochemically there is appearance of both lipoproteins, with complete reversal to normal lipoprotein pattern in the end.

Acute Disease↗
PubMed1970

Defibrination syndrome due to scorpion venom poisoning.

Disseminated intravascular coagulation occurred in dogs given scorpion venom subcutaneously in doses of 3 mg./kg. body weight. Treatment with heparin reversed the coagulation abnormality of the syndrome and 10 out of 12 dogs survived. Necropsy findings in human patients stung by scorpions suggest that this syndrome also occurs in man.

Animals↗