Biomedical subjects

C S Feng

Publications and source records attributed to C S Feng.

6 recordsLinked to original sources

PubMed1992

Long-term survival of a baby with homozygous alpha-thalassemia-1.

Triplets born to a Chinese woman consisted of 2 healthy boys and a girl with hemoglobin Bart's hydrops syndrome. The girl with hemoglobin Bart's hydrops syndrome, confirmed by gene analysis to be homozygous for alpha-thalassemia-1, survives for 27 months at the time of reporting. The dilemma in sustaining her life and the availability of other therapeutic options are briefly discussed. This is the third case report of homozygous alpha-thalassemia-1 with long-term survival.

Child, Preschool↗

PubMed1991

Gelatinous transformation of marrow in a case of acute myelogenous leukemia post-chemotherapy.

Gelatinous transformation of marrow in a patient with acute myelogenous leukemia was reported. This case was at variance with other reported cases of gelatinous transformation of marrow in that a) it was associated with a primary bone marrow disease and b) there was no fat atrophy and the patient was not cachectic. The fact that it occurred abruptly post-chemotherapy suggested that marrow hypoplasia induced by chemotherapy could be the cause of this lesion in this particular situation.

Antineoplastic Combined Chemotherapy Protocols↗

PubMed1991

An unusual case of hairy cell leukemia: death due to leukostasis and intracerebral hemorrhage.

Hairy cell leukemia (HCL) was diagnosed in a 71-year-old Chinese man. His clinical presentation and the characteristics of the hairy cells were typical of classic HCL. However, extreme leukocytosis (195 to 323 x 10(9) cells/L) in peripheral blood was in striking contrast. This leukocytosis, which was much more pronounced than any of the reported cases of HCL with leukocytosis, was associated with leukostasis in the cerebral vasculature and was causally related to a massive intracerebral hemorrhage and death. This mode of death in HCL has not been reported previously.

Aged↗

PubMed1991

An analysis of donor blood wastage due to outdating in a large teaching hospital.

We analyzed the pattern and rate of donor blood outdating in our hospital from 1986 to 1990. We found that there was a sharp drop in blood outdating since the implementation of the Type and Screen crossmatch protocol. The outdating rate was reduced from 11.5% to 1.3% for whole blood and from 4.9% to 0.4% for red cells. In absolute numbers, wastage of blood due to outdating was cut from 2,570 units in 1986-87 (a 2 yr period before Type and Screen) to only 227 units in 1988-89 (a 2 yr period after Type and Screen). We also found that the outdating rate varied among different blood groups (group 0 less than A = B less than AB), and the outdating of whole blood was consistently more than red cells throughout the study period. The results of our utilization review were conveyed to local hospitals and the blood supplier in an effort to preserved donor blood.

Blood Donors↗

PubMed1979

Detection of hepatitis B surface antigen with the miniature centrifugal fast analyzer. A modified reversed passive hemagglutination procedure.

A modified reversed passive hemagglutination test for the detection of hepatitis B surface antigen HBsAg is described. Sera and reagent cells coated with antibody to HBsAg (anti-HBs) are loaded separately into the rotor of a miniature centrifugal fast analyzer. The rotor is centrifuged briefly to transfer the components into its cuvettes. After mixing, the suspensions are allowed to stand at room temperature for 30 min, following which the rotor is again centrifuged and the absorbance of each cuvette is monitored. Cells suspended in serum containing HBsAg leave the light path more rapidly than cells suspended in sera free of antigen. The magnitude of change in absorbance varies directly with the concentration of the antigen. In 45 sera tested by the conventional V-plate technique, findings were as follows: 21 positive, 19 false positive and 5 negative. The automated procedure unequivocally differentiated the 21 positives; results for the false positive and negative specimens were identical and clearly distinguishable from the positive results. The automated procedure enhances specificity, offers equivalent sensitivity, and results that are quantitative and objective.

Absorption↗

PubMed1979

Improved method for detecting hemagglutination by centrifugal analysis.

Centrifugal analysis can be used to detect hepatitis B surface antigen, antibody to rubella virus, and fibrin-related antigen. The procedure is performed with the same reagents used in conventional hemagglutination studies. Positive and negative reactions are distinguished by the rates of erythrocyte clearance in the centrifugal field (delta A/delta time); positive cells move more rapidly than negative cells, and this difference varies directly with the concentration of detectable antigen or antibody. This phenomenon is thought to be a result of the greater adhesion of negative cells to the cuvette's surface. Sensitivity and specificity are greater in the centrifugal analysis technique than in the more conventional hemagglutination tests. False-positive reactions are eliminated and the quantitative data are accurate and reproducible.

Antibodies↗