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Biomedical subjects

C S Hollander

Publications and source records attributed to C S Hollander.

At least 55 records · Page 3Linked to original sources
PubMed1975

Measurements of the effective thyroxine ratio (ETR) in the neonate, infant, and child.

The applicability of the effective thyroxine ratio (ETR) was assessed in euthyroid neonates, infants, and children. ETR determinations on cord blood fell within the normal adult range. In contrast, ETR values of newborns age 4 hr to 2 days were all elevated (1.17 -1.37) and within the hyperthyroid range for adults. Values in infants age 2 weeks and older and in children age 1-15 years all fell within the normal adult range. These findings suggest that the ETR can be used as an ancillary measure of thyroid function in infants and children. In the immediate postpartum period, however, ETR values may be normally in the adult hyperthyroid range.

Adolescent↗
PubMed1974

Prostaglandins stimulate thyroid function in pregnant women.

Intravaginal or intravenous administration of prostaglandin F(2alpha) to pregnant women produced significant elevations of plasma triiodothyronine and thyroxine concentrations, but no rise of thyrotropin. These observations are consistent with those of previous in vitro studies indicating that prostaglandins can act directly on the thyroid gland to stimulate thyroid hormone synthesis or release, or both.

Female↗
PubMed1973

Modulation of pituitary responsiveness to thyrotropin-releasing hormone by triiodothyronine.

The relative roles of triiodothyronine (T(3)) and thyroxine (T(4)) in modulating pituitary responsiveness to thyrotropin-releasing hormone (TRH) have been assessed. (a) 10 hyperthyroid patients with elevated serum T(2) and T(4) levels showed no pituitary response to TRH. After 2 wk of propylthiouracil therapy T(4) levels had fallen to normal in only five patients while T(2) levels were normal in all. Pituitary responsiveness to TRH returned in all patients with normal or high T(4) concentrations. (b) Patients with isolated elevations of serum T(3) (T(3) toxicosis) failed to respond to TRH. TRH responsiveness was restored when T(3) levels fell to normal after propylthiouracil therapy. (c) When pituitary responsiveness to TRH was tested 60 min after a single oral dose of 50 mug of T(3), which increased serum T(3) levels to slightly above the normal range, no rise in thyrotropin (TSH) was seen in six subjects. These findings indicate that T(3) elevations alone can rapidly inhibit pituitary responsiveness to TRH.

Administration, Oral↗