Fatal perforating intestinal ulceration attributable to flunixin meglumine overdose in rats.
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Anesthesia↗
Biomedical subjects
C S King
Publications and source records attributed to C S King.
Choose a path.
Managed care, organizational downsizing, and reengineering create two different paths for nurses to choose: one of opportunity and one of victimization. APNQ interviews author Jane Schweitzer and features excerpts from her book Tears and Rage: The Nursing Crisis in America.
Choice Behavior↗
Effects of continuous glucocorticoid infusion on bone metabolism in the rat.
The effects of continuous administration of supraphysiologic doses of dexamethasone (DEX) on bone metabolism were examined in rats. Adult, male, Sprague Dawley rats were infused with DEX at a constant rate of 16.25 microg/day for 19 days. Despite soft tissue catabolism, DEX treatment led to a significant increase in bone volume in all experiments. This was accompanied by a significant gain in femoral weight and calcium content. These findings were also observed in DEX-treated parathyroidectomized animals indicating that intact parathyroid function was not required for this effect. DEX treatment did not affect mean levels of serum calcium or phosphorus but led to significant declines in circulating levels of PTH and 1,25(OH)2D and in the urinary calcium/creatinine ratio. This latter finding was also observed in PTX animals in which 1,25(OH)2D levels did not change. Serum concentrations of osteocalcin and tartrate-resistant acid phosphatase both declined in a time-dependent manner with DEX treatment suggesting a slowing of bone turnover with the net effect favoring formation. However, histomorphometric findings were variable. Two of three experiments demonstrated a decrease in cellular parameters of formation and resorption and in one experiment, these indices increased. Mineralized surface increased with DEX treatment. We conclude that, in marked contrast to the findings in man and certain other species, DEX treatment increases bone mass in rats. This may in part relate to a relatively greater suppression of resorption vis à vis formation.
Animals↗
The politics of advanced practice.
Nurses have a unique opportunity to influence the future. Practice opportunities abound for advanced practice nurses in emerging health delivery models. Practice barriers, external as well as those created by nursing, must be addressed. Politically savvy nurses can use their understanding of power and politics to effect changes that can maximize advanced practice nurses' contributions to the health of our society.
Delivery of Health Care↗
Nesidioblastosis associated with hyperglycemia in two squirrel monkeys (Saimiri sciureus).
Nesidioblastosis associated with progressive weight loss and hyperglycemia was diagnosed in two mid-adult, wild-caught, male squirrel monkeys (Saimiri sciureus). Hyperglycemia, glucosuria, and abnormal glucose tolerance test results were found when the monkeys were presented for clinical evaluation for chronic weight loss, episodic dehydration, hypothermia, and lethargy. Immunohistochemical studies of the pancreatic tissue demonstrated that the proliferating endocrine cells stained predominantly glucagon-positive in the most severely affected monkey.
Animals↗
Collaboration and the practice of nurse-midwifery.
In the United States there are growing examples of physician and certified nurse-midwife collaborations capitalizing on the strengths of both disciplines working in the best interest of the patient and her family. The philosophy and practice of certified nurse-midwives (CNMs), however, are not embraced universally by all physicians, and childbirth continues to be treated and reimbursed as a disease process. As Americans seek to establish a partnership with those providing their care, they will naturally embrace advanced practice nurses and reach a mutually beneficial health outcome.
Cooperative Behavior↗
Healing in the midst of chaos.
All aboard for an imaginary journey to the village of Health Care Chaos where the different actors and issues involved in the very real state of health care come alive. The author incorporates an interview with Virginia Trotter Betts, President of the American Nurses Association, to highlight the controversy surrounding the involvement and role of advanced practice nurses.
Cooperative Behavior↗
Ending the silent conspiracy: sexual harassment in nursing.
Sexual harassment in health care institutions presents a formidable challenge for nurse leaders as solutions and accountabilities get mired in power, politics, and a historical tradition of secrecy and silence. Harassment is devastating to all individuals, but especially to women because it blatantly violates the victim's personal autonomy and individual sense of equality. Sexual harassment lingers in the corridors of all types of organizations, preying on women as they struggle to overcome cultural and socially imposed barriers. Nurse executives must learn the subtle complexities surrounding harassment, voice strong opposition against harassment, and take swift and comprehensive action to prevent sexual harassment.
Female↗
Susceptibility and signs associated with mouse adenovirus type 1 infection of adult outbred Swiss mice.
Adult Swiss outbred mice from two sources had a nearly 6,000-fold difference in susceptibility to mouse adenovirus type 1-induced disease. This difference was not attributable to differential organ tropism. Signs associated with mouse adenovirus type 1 infection that have not been previously reported are described at the clinical, gross pathological, and histological levels.
Adenoviridae↗
Second licensure.
"Question the Answers" is a column in Advanced Practice Nursing Quarterly featuring a lively discussion of contemporary, and at times, controversial issues in advanced practice nursing. The column will incorporate written testimony from clinical and educational experts from the editorial board as well as from the field. Contact column editor: Cheryl Slagle King, MPM, RN, CNAA, to contribute to this feature.
Humans↗
Prescriptive authority.
"Question the Answers" is a column in Advanced Practice Nursing Quarterly featuring a lively discussion of contemporary, and at times, controversial issues in advanced practice nursing. The column will incorporate written testimony from clinical and educational experts from the editorial board as well as from the field. Contact column editor: Cheryl Slagle King, MPM. RN, CNAA, to contribute to this feature.
Drug Prescriptions↗
Cavernous lymphangioma in a squirrel monkey.
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Animals↗
Carcinoma of the cervix and cervical cytology--short epidemiological review.
Carcinoma of the cervix is an important disease of well-documented epidemiology but uncertain cause. It causes appreciable morbidity and mortality in all countries, including Zimbabwe, with a significant load on curative services. Epidemiology and the role of cytology are reviewed. Cytology screening programmes have suffered from an inability to cover whole populations, particularly less affluent and/or socially disadvantaged groups, which are most at risk. Despite this difficulty, the magnitude of the problem makes it necessary to continue its study. In particular, efforts are needed in developing countries to study incidence, to better define high risk groups and to devise economical ways of detecting more cases in the earlier stages.
Carcinoma, Squamous Cell↗
Accurate determination of the transaortic valve gradient using simultaneous left ventricular and femoral artery pressures.
Accurate determination of the transaortic valve gradient has required two catheters, one in the left ventricle and one in the ascending aorta. We now report a new technique for measurement of the transaortic valve gradient from the simultaneous left ventricular (LV) and femoral artery (FA) pressure tracings. This technique was compared with the "true" gradient obtained by measurement of the simultaneous LV and central aortic pressures, and is accurate (R = 0.999) and relatively simple. Other approaches used to determine the mean transaortic valve gradient were less accurate: simultaneous LV-FA (R = 0.991); aligned LV-FA (R = 0.974); averaged simultaneous and aligned LV-FA (R = 0.981); and nonsimultaneous LV-aorta pullback (R = 0.953). Thus, this new technique provides an accurate transaortic valve gradient without requiring the use of two central catheters.
Aorta↗
Selective inhibition of nerve growth factor-stimulated protein kinases by K-252a and 5'-S-methyladenosine in PC12 cells.
K-252a, a protein kinase inhibitor isolated from the culture broth of Nocardiopsis sp., inhibits the nerve growth factor (NGF)-stimulated phosphorylation of microtubule-associated protein 2 (MAP2) and Kemptide (synthetic Leu-Arg-Arg-Ala-Ser-Leu-Gly) by blocking the activation of two independent kinases in PC12 cells: MAP2/pp250 kinase and Kemptide kinase. The NGF-stimulated activation of these kinases is inhibited in a dose-dependent manner following treatment of the cells with K-252a. Although these kinases also are activated by epidermal growth factor (EGF) and 12-O-tetradecanoyl-phorbol 13-acetate, K-252a has no inhibitory effect when these agents are used. Half-maximal inhibition of the activation of both kinases was observed at 10-30 nM K-252a. K-252a was shown to directly inhibit the activity of MAP2/pp250 kinase and Kemptide kinase when added to the phosphorylation reaction mixture in vitro; however, half-maximal inhibition under these conditions was observed at greater than or equal to 50 nM K-252a. These data suggest that K-252a exerts its effects at a step early in the cascade of events following NGF binding. The effects of K-252a are similar to those reported for 5'-S-methyladenosine (MTA) and other methyltransferase inhibitors. Treatment of PC12 cells with MTA inhibited NGF-, but not EGF-mediated activation of MAP2/pp250-kinase (Ki greater than 500 microM). MTA, when added to the phosphorylation reaction mixture in vitro, directly inhibited kinase activity (Ki = 50 microM), suggesting that the effects of MTA may be the result of its action on protein kinases rather than methyltransferases.
Adenosine↗
Choriocarcinoma presenting as an intussusception--a case report.
A case of choriocarcinoma presenting as an ileo-ileal intussusception in a sixteen year old girl is presented. Review of the literature reveals this to be the second case ever reported with such an unusual presentation of choriocarcinoma.
Adult↗
p56lck protein-tyrosine kinase is cytoskeletal and does not bind to polyomavirus middle T antigen.
p56lck and p60c-src are closely related protein-tyrosine kinases that are activated by similar oncogenic mutations. We have used fibroblast cell lines that express p56lck from introduced DNA molecules to compare the subcellular localizations of p60c-src and p56lck and their abilities to bind polyomavirus middle T antigen (mT). p56lck is associated with the detergent-insoluble matrix, as defined by extraction with solutions containing nonionic detergents, whereas p60c-src is soluble under these conditions. p56lck is also associated with detergent-insoluble structures in a lymphoid cell line, LSTRA. p60c-src binds to mT, but p56lck does not bind detectably. In terms of both solubility and mT interactions, the nononcogenic p56lck more closely resembles oncogenically activated p60c-src mutants than it resembles p60c-src. Because published results show that an intact carboxy terminus is required for p60c-src to bind mT and be soluble, we tested whether the different localization and mT binding properties of p56lck and p60c-src were dictated by their different carboxy termini. A protein consisting largely of p60c-src sequences but carrying a p56lck carboxy terminus was soluble and bound to mT. We suggest that both the solubility and mT-binding properties of p60c-src not only require sequences common to the carboxy termini of p60c-src and p56lck, but also require sequences unique to the body of p60c-src.
Animals↗
Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).
The lck proto-oncogene encodes a lymphocyte-specific member of the src family of protein tyrosine kinases. Here we demonstrate that pp56lck is phosphorylated in vivo at a carboxy-terminal tyrosine residue (Tyr-505) analogous to Tyr-527 of pp60c-src. Substitution of phenylalanine for tyrosine at this position resulted in increased phosphorylation of a second tyrosine residue (Tyr-394) and was associated with an increase in apparent kinase activity. In addition, this single point mutation unmasked the oncogenic potential of pp56lck in NIH 3T3 cell transformation assays. Viewed in the context of similar results obtained with pp60c-src, it is likely that the enzymatic activity and transforming ability of all src-family protein tyrosine kinases can be regulated by carboxy-terminal tyrosine phosphorylation. We further demonstrate that overexpression of pp56lck in the murine T-cell lymphoma LSTRA as a result of a retroviral insertion event produces a kinase protein that despite wild-type primary structure is nevertheless hypophosphorylated at Tyr-505. Thus, control of normal growth in this lymphoid cell line may have been abrogated through acquisition of a posttranslationally activated version of pp56lck.
Animals↗