Biomedical subjects

C S Planeta

Publications and source records attributed to C S Planeta.

4 recordsLinked to original sources

PubMed1991

Effect of fencamfamine on avoidance performances of rats.

The effects of fencamfamine (1.0 and 5.0 mg/kg, ip, single dose) on an inhibitory task were studied in rats (N = 15 per group). Post-training treatment with fencamfamine (1.0 mg/kg) significantly increased avoidance latency from 23 +/- 3 to 146 +/- 28 and 170 +/- 33 s for training day 1 and day 7, respectively, indicating an enhancement of retention. However, retention was significantly reduced with a high dose of fencamfamine (5.0 mg/kg). These results demonstrate that fencamfamine caused a reproducible dose-related increase and reduction in avoidance latency.

Animals↗

PubMed1990

Fencamfamine.

1. Studies on the mechanisms of FCF action using behavioural and biochemical methods have shown that all stimulant effects produced by acute administration of FCF are thought to be due to indirect activation of DA systems in CNS. 2. Changes in the sensitivity of pre- or postsynaptic DA receptors might underlie both tolerance and sensitization to the effects induced by long-term FCF administration.

Animals↗

PubMed1989

On the mechanism which mediates the effects of long-term administration of fencamfamine in rats.

This study analyzes the changes in the sensitivity of striatal dopaminergic (DA) receptors to apomorphine following withdrawal from long-term treatment with fencamfamine (10 mg/kg, for 40 days). Fencamfamine treatment decreased (34.8 +/- 3.2 vs 25.8 +/- 2.8, P less than 0.05) the stereotyped behavior induced by apomorphine (2.0 mg/kg, sc), but potentiated the effect of apomorphine (0.02 mg/kg, sc) in reducing the striatal levels of homovanillic acid (HVA) (0.41 +/- 0.02 micrograms/g vs 0.31 +/- 0.03 micrograms/g, P less than 0.01) and dihydroxyphenylacetic acid (DOPAC) (0.45 +/- 0.04 micrograms/g vs 0.34 +/- 0.03 micrograms/g, P less than 0.01). These results suggest that changes in pre- or postsynaptic DA receptors may underlie the tolerance and sensitization to the effects of fencamfamine.

Animals↗

PubMed1987

Behavioural effects of long-term administration of fencamfamine: neurochemical implications.

The repeated effects of fencamfamine administration (10.0 mg/kg, i.p. single dose) were studied in male rats. Fencamfamine treatment increased stereotyped sniffing and decreased rearing behaviour. These changes occurred after 8 days of treatment and remained for 25 days. The fencamfamine repeated administration enhanced the homovanillic acid (HVA) level in the tubercullum olfactorium while the same treatment decreased the dihydroxyphenilacetic acid (DOPAC) and HVA striatal levels. The data suggest that long-term fencamfamine administration develops changes in the activity of parts of the DA systems which might be responsible for tolerance or sensitization to the effects of fencamfamine.

3,4-Dihydroxyphenylacetic Acid↗