Biomedical subjects

C S Ting

Publications and source records attributed to C S Ting.

15 recordsLinked to original sources

PubMed2006

Fluctuation-exchange study of antiferromagnetism in disordered electron-doped cuprate superconductors.

On the basis of the Hubbard model, we extend the fluctuation-exchange (FLEX) approach to investigating the properties of the antiferromagnetic (AF) phase in electron-doped cuprate superconductors. Furthermore, by incorporating the effect of scatterings due to the disordered dopant atoms into the FLEX formalism, our numerical results show that the antiferromagnetic transition temperature, the onset temperature of pseudogap due to spin fluctuations, the spectral density of the single particle near the Fermi surface, and the staggered magnetization in the AF phase as a function of electron doping can consistently account for the experimental measurements.

Journal Article↗

PubMed2006

Theory of the phonon Hall effect in paramagnetic dielectrics.

Based upon Raman spin-lattice interaction, we propose a theoretical model for the phonon Hall effect in paramagnetic dielectrics, which was discovered recently in an experiment [C. Strohm, G. L. J. A. Rikken, and P. Wyder, Phys. Rev. Lett. 95, 155901 (2005).]. The phonon Hall effect is revealed to be a phonon analogue to the anomalous Hall effect in electron systems. The thermal Hall conductivity is calculated by using the Kubo formula. Our theory reproduces the essential experimental features of the phonon Hall effect, including the sign, magnitude, and linear magnetic field dependence of the thermal Hall conductivity.

Journal Article↗

PubMed2006

Local tunneling spectroscopy as a signature of the Fulde-Ferrell-Larkin-Ovchinnikov state in s- and d-wave superconductors.

The Fulde-Ferrell-Larkin-Ovchinnikov (FFLO) states for two-dimensional s- and d-wave superconductors (s- and d-SCs) are self-consistently studied under an in-plane magnetic field. While the stripe solution of the order parameter is found to have lower free energy in s-SCs, a square lattice solution appears to be energetically more favorable in the case of d-SCs. At certain symmetric sites, we find that the features in the local density of states (LDOS) can be ascribed to two types of bound states. We also show that the LDOS maps for d-SCs exhibit bias-energy-dependent checkerboard patterns. These characteristics can serve as signatures of the FFLO states.

Journal Article↗

PubMed2005

Nondissipative spin Hall effect via quantized edge transport.

The spin Hall effect in a two-dimensional electron system on honeycomb lattice with both intrinsic and Rashba spin-orbit couplings is studied numerically. Integer quantized spin Hall conductance is obtained at the zero Rashba coupling limit when electron Fermi energy lies in the energy gap created by the intrinsic spin-orbit coupling, in agreement with recent theoretical prediction. While nonzero Rashba coupling destroys electron spin conservation, the spin Hall conductance is found to remain near the quantized value, being insensitive to disorder scattering, until the energy gap collapses with increasing the Rashba coupling. We further show that the charge transport through counterpropagating spin-polarized edge channels is well quantized, which is associated with a topological invariant of the system.

Journal Article↗

PubMed2005

Spin-Hall effect in two-dimensional electron systems with Rashba spin-orbit coupling and disorder.

Using the four-terminal Landauer-Bu ttiker formula and Green's function approach, we calculate numerically the spin-Hall conductance in a two-dimensional junction system with the Rashba spin-orbit (SO) coupling and disorder. We find that the spin-Hall conductance can be much greater or smaller than the universal value e/8pi, depending on the magnitude of the SO coupling, the electron Fermi energy, and the disorder strength. The spin-Hall conductance does not vanish with increasing sample size for a wide range of disorder strength. Our numerical calculation reveals that a nonzero SO coupling can induce electron delocalization for disorder strength smaller than a critical value, and the nonvanishing spin-Hall effect appears mainly in the metallic regime.

Journal Article↗

PubMed2004

States of local moment induced by nonmagnetic impurities in cuprate superconductors.

By using a model Hamiltonian with d-wave superconductivity and competing antiferromagnetic (AF) orders, the local staggered magnetization distribution due to nonmagnetic impurities in cuprate superconductors is investigated. We show that the net moment induced by a single impurity corresponds to a local spin with S(z)=0 or 1/2 depending on the strength of the AF interaction U and the impurity scattering strength epsilon. Phase diagram of epsilon versus U for the moment formation is presented. We discuss the connection of this result with the Kondo problem. When two impurities are placed at the nearest neighboring sites, the net moment is always zero, unusually robust to parameter changes. For two neighboring strong impurities, separated by a Cu-ion site, the induced net moment has S(z)=0, 1/2, or 1.

Journal Article↗

PubMed2002

Vortex charges in high-temperature superconductors.

Based on a model Hamiltonian with competing antiferromagnetic (AF) and d-wave superconductivity interactions, the vortex charge is investigated by solving the Bogoliubov-de Gennes equations. We found that the vortex charge is negative when a sufficient strength of AF order is induced inside the vortex core; otherwise, it is positive. By tuning the on-site Coulomb repulsion U or the doping parameter delta, a transition between the positive and negative vortex charges may occur. The vortex charge at optimal doping has also been studied as a function of magnetic field. Recent NMR and Hall effect experiments may be understood in terms of the present results.

Journal Article↗

PubMed2001

Quasiparticle states around a nonmagnetic impurity in a d-density-wave state of high-T(c) cuprates.

The electronic structure around a single nonmagnetic impurity in the d-density-wave (DDW) ordering is studied. It is found that a single subgap resonance peak appears in the local density of states around the impurity. In the unitary limit, the position of this resonance peak shifts away from the Fermi energy in accord with the chemical potential. This result is dramatically different from the case of the pure superconducting state for which the impurity resonant energy is approximately pinned at the Fermi level. This can be used to probe the existence of the DDW ordering in cuprates.

Journal Article↗

PubMed2001

Quasiparticle states at a d-wave vortex core in high- T(c) superconductors: induction of local spin density wave order.

The local density of states (LDOS) at the vortex lattice cores in a high- T(c) superconductor is studied by using a self-consistent mean-field theory including interactions for both antiferromagnetism (AF) and d-wave superconductivity (DSC). In a zero-field optimally doped sample the AF order is completely suppressed while DSC prevails. In the mixed state, we show that the local AF-like spin density wave order appears near the vortex core and acts as an effective local magnetic field on electrons via Zeeman coupling. As a result, the LDOS at the core exhibits a double-peak structure near the Fermi level that is in good agreement with recent scanning tunneling microscopy observations.

Journal Article↗

PubMed2001

The photosynthetic apparatus of Prochlorococcus: Insights through comparative genomics.

Within the vast oceanic gyres, a significant fraction of the total chlorophyll belongs to the light-harvesting antenna systems of a single genus, Prochlorococcus. This organism, discovered only about 10 years ago, is an extremely small, Chl b-containing cyanobacterium that sometimes constitutes up to 50% of the photosynthetic biomass in the oceans. Various Prochlorococcus strains are known to have significantly different conditions for optimal growth and survival. Strains which dominate the surface waters, for example, have an irradiance optimum for photosynthesis of 200 mumol photons m(-2) s(-1), whereas those that dominate the deeper waters photosynthesize optimally at 30-50 mumol photons m(-2) s(-1). These high and low light adapted 'ecotypes' are very closely related - less than 3% divergent in their 16S rRNA sequences - inviting speculation as to what features of their photosynthetic mechanisms might account for the differences in photosynthetic performance. Here, we compare information obtained from the complete genome sequences of two Prochlorococcus strains, with special emphasis on genes for the photosynthetic apparatus. These two strains, Prochlorococcus MED4 and MIT 9313, are representatives of high- and low-light adapted ecotypes, characterized by their low or high Chl b/a ratio, respectively. Both genomes appear to be significantly smaller (1700 and 2400 kbp) than those of other cyanobacteria, and the low-light-adapted strain has significantly more genes than its high light counterpart. In keeping with their comparative light-dependent physiologies, MED4 has many more genes encoding putative high-light-inducible proteins (HLIP) and photolyases to repair UV-induced DNA damage, whereas MIT 9313 possesses more genes associated with the photosynthetic apparatus. These include two pcb genes encoding Chl-binding proteins and a second copy of the gene psbA, encoding the Photosystem II reaction center protein D1. In addition, MIT 9313 contains a gene cluster to produce chromophorylated phycoerythrin. The latter represents an intermediate form between the phycobiliproteins of non-Chl b containing cyanobacteria and an extremely modified beta phycoerythrin as the sole derivative of phycobiliproteins still present in MED4. Intriguing features found in both Prochlorococcus strains include a gene cluster for Rubisco and carboxysomal proteins that is likely of non-cyanobacterial origin and two genes for a putative varepsilon and beta lycopene cyclase, respectively, explaining how Prochlorococcus may synthesize the alpha branch of carotenoids that are common in green organisms but not in other cyanobacteria.

Journal Article↗

PubMed2001

Phycobiliprotein genes of the marine photosynthetic prokaryote Prochlorococcus: evidence for rapid evolution of genetic heterogeneity.

Prochlorococcus is a major photosynthetic prokaryote in nutrient-limited, open ocean environments and an important participant in the global carbon cycle. This phototroph is distinct from other members of the cyanobacterial lineage to which it belongs because it utilizes a chlorophyll a2/b(2) light-harvesting complex as its major antenna, instead of phycobilisomes. Recently, genes encoding the phycobiliprotein phycoerythrin were identified in several Prochlorococcus isolates, thus making it the only extant photosynthetic prokaryote to possess a chlorophyll a/b antenna as well as phycobiliprotein genes. In order to understand the evolution of phycobiliproteins in this genus, the authors have sequenced the phycoerythrin genes of two isolates that are the most deeply branching in the Prochlorococcus lineage and share the highest degree of 16S rDNA sequence similarity to phycobilisome-containing marine SYNECHOCOCCUS: Sequence analyses suggest that within the Prochlorococcus lineage, the selective forces shaping the evolution of the phycoerythrin gene set have not been uniform. Although strains that are most closely related to marine Synechococcus possess genes (cpeB, cpeA) encoding both subunits of phycoerythrin, a more recently evolved strain is shown to lack cpeA and to possess a degenerate form of cpeB. Differences in phycoerythrin gene sequences between Prochlorococcus and Synechococcus appear to be consistent with a model of elevated mutation rates rather than relaxed selection. This suggests that although phycoerythrin is not a major constituent of the light-harvesting apparatus in Prochlorococcus, as it is in Synechococcus, the cpeB and cpeA genes are still under selection, albeit a different type of selection than in Synechococcus. The evolution of the Prochlorococcus light-harvesting antenna complex provides an important system for understanding the origins and scope of phylogenetic diversity in ocean ecosystems.

Amino Acid Sequence↗

PubMed2001

Whole proteome pI values correlate with subcellular localizations of proteins for organisms within the three domains of life.

Isoelectric point (pI) values have long been a standard measure for distinguishing between proteins. This article analyzes distributions of pI values estimated computationally for all predicted ORFs in a selection of fully sequenced genomes. Histograms of pI values confirm the bimodality that has been observed previously for bacterial and archaeal genomes () and reveal a trimodality in eukaryotic genomes. A similar analysis on subsets of a nonredundant protein sequence database generated from the full database by selecting on subcellular localization shows that sequences annotated as corresponding to cytosolic and integral membrane proteins have pI distributions that appear to correspond with the two observed modes of bacteria and archaea. Furthermore, nuclear proteins have a broader distribution that may account for the third mode observed in eukaryotes. On the basis of this association between pI and subcellular localization, we conclude that the bimodal character of whole proteome pI values in bacteria and archaea and the trimodal character in eukaryotes are likely to be general properties of proteomes and are associated with the need for different pI values depending on subcellular localization. Our analyses also suggest that the proportions of proteomes consisting of membrane-associated proteins may be currently underestimated.

Animals↗

PubMed1995

Effects of indomethacin on lymphokine-activated killer cell activities in cancer patients.

Prostaglandin E2 (PGE2) is known to downregulate the generation of lymphokine-activated killer (LAK) cell activity. Indomethacin, an inhibitor of cyclooxygenase catalyzing the biosynthesis of PGE2, has been shown to augment LAK cell activities generated from peripheral blood mononuclear cells of normal healthy individuals. This study was undertaken to examine whether or not this augmentation is also a common phenomenon in cancer patients. LAK cell activities generated in the presence and the absence of indomethacin were examined in 15 normal healthy individuals and in 83 cancer patients. Paired data analysis revealed that indomethacin exhibited a significant augmentation of LAK activity generated from healthy individuals. Indomethacin enhanced LAK activity in patients with no distant metastases (TxNxM0); but depressed LAK activity in patients with distant metastases (TxNxM1). In patients without distant metastases, indomethacin showed an upregulating effect on LAK activity in those with an early T stage (T1-2NxM0), and no such effect was detected in those with a late T stage (T3-4NxM0). Indomethacin also significantly enhanced LAK cell generation in cancer patients with an ECOG performance status of 1, but significantly inhibited LAK cell generation in patients with a performance status of 4. These results indicated that indomethacin inhibited generation of LAK cell activity in cancer patients with a poor performance status or with distant metastatic disease, who normally would be the subjects of adoptive immunotherapy. Further, PGE2 production in cultured LAK cell medium was suppressed by indomethacin in all 20 cancer patients that were examined, suggesting that other yet to be identified factors or mechanisms may be responsible for the paradoxical effects of indomethacin on LAK cell activity.

Adjuvants, Immunologic↗

PubMed1993

The augmentation of lymphokine-activated killer cell activity by indomethacin in vitro is not mediated by prostaglandin E2 suppression.

The effects of three nonsteroidal antiinflammatory drugs (NSAIDs), namely, indomethacin, aspirin, and mefenamate (ponstan), on the lymphokine-activated killer (LAK) cell activities generated from coculturing recombinant interleukin-2 (rIL-2) and normal human peripheral blood mononuclear cells (PBMCs) for 3 to 4 days were investigated. The LAK cell activities were measured by a 4 hour 51Cr release microcytotoxicity assay using HL-60 and K-562 as target cells. Indomethacin was found to have significant augmenting effect on LAK cell activity at the concentration of 5 x 10(-5) M, whereas aspirin and ponstan did not show the same effect at the same concentration. Additional experiments, however, demonstrated that all of these 3 agents could effectively suppress the production of prostaglandin E2 (PGE2) in the culture medium. These results indicated that PGE2 suppression may not be the only mechanism of indomethacin for upregulation of LAK cell activity, and even immune functions.

Aspirin↗

PubMed1992

Limitations of the pulse-modulated technique for measuring the fluorescence characteristics of algae.

Precise measurements of the minimal fluorescence yield (F(o)) and maximal fluorescence yield (F(m)) of a dark-adapted sample are prerequisites for the quantification of other fluorescence parameters. The pulse amplitude-modulated chlorophyll fluorometer (PAM 101 Chlorophyll Fluorometer, Heinz Walz, Effeltrich, Germany) and saturating pulse technique have frequently been used in measuring F(o) and F(m) and in resolving the contributions of photochemical and nonphotochemical quenching to the total fluorescence yield. The extent to which instrument-dependent factors may affect the accurate measurement of F(o) and F(m) is addressed. It is shown that the increase in pulse amplitude-modulated measuring beam intensity at 1.6 and 100 kHz was nonlinear at higher light intensity settings. The implications of this for measurements of F(o) (1.6 kHz) and F(m) (100 kHz) are discussed. It is also demonstrated that underestimation of F(m) may result due to saturation of the PAM 101 photodiode by scattered infrared light associated with intense light pulses. In addition, it is shown how sample-dependent factors may affect measurements of F(o) and F(m) in samples with low chlorophyll concentrations, in particular, dilute algal suspensions of Phaeodactylum tricornutum and Chlamydomonas reinhardtii. A technique is presented for the accurate measurement of F(o) in algal suspensions (<8 mug chlorophyll a mL(-1)). The importance of examining the saturating pulse transient and F(m) level as a function of the damping setting, pulse width, and pulse intensity, and in the presence of 3-(3,4-dichlorophenyl)-1, 1-dimethylurea is discussed.

Journal Article↗