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Biomedical subjects

C Sale

Publications and source records attributed to C Sale.

7 recordsLinked to original sources
PubMed2002

Effects of resistance training and detraining on muscle strength and blood lipid profiles in postmenopausal women.

OBJECTIVES: To study the effects of eight weeks of supervised, low intensity resistance training (80% of 10 repetition maximum (10RM)) and eight weeks of detraining on muscle strength and blood lipid profiles in healthy, sedentary postmenopausal women. SUBJECTS: Fifteen postmenopausal women, aged 49-62 years, took part in the study. Subjects were assigned to either a control (n = 7) or training (n = 8) group. The training regimen consisted of three sets of eight repetitions of leg press, bench press, knee extension, knee flexion, and lat pull-down, three days a week at 80% of 10RM. Dynamic leg strength, 10RM, and blood lipid profiles (total cholesterol (TC), low and high density lipoprotein cholesterol (LDL-C, HDL-C), triglycerides, and very low density lipoprotein cholesterol (VLDL-C)) were measured at baseline, after eight weeks of training, and after a further eight weeks of detraining. RESULTS: Eight weeks of resistance training produced significant increases in knee extension (F(1,13) = 12.60; p<0.01), bench press (F(1,13) = 13.79; p<0.01), leg press (F(1,13) = 15.65; p<0.01), and lat pull-down (F(1,13) = 16.60; p<0.005) 10RM strength tests. Although 10RM strength decreased after eight weeks of detraining, the results remained significantly elevated from baseline measures. Eight weeks of training did not result in any significant alterations in blood lipid profiles, body composition, or dynamic isokinetic leg strength. There were no significant differences in any of the variables investigated over the 16 week period in the control group. CONCLUSIONS: These data suggest that a short, low intensity resistance training programme produces substantial improvements in muscle strength. Training of this intensity and duration was not sufficient to produce significant alterations in blood lipid concentrations.

Blood Pressure↗
PubMed2000

Individual differences, exercise and leisure activity in predicting affective well-being in young adults.

This study focuses on the prevalence of exercise and health-related leisure activities (smoking, drinking), across groups of subjects, defined by personality and gender, in relation to subjective well-being. Results from a cross-sectional survey of 187 participants are reported. Males (n = 80) reported more drinking (p < 0.001) and smoking (p < 0.001) than females, though they also reported higher habitual physical activity levels (p < 0.001). Females (n = 107) reported more frequent use of social support coping (p < 0.01). There was a positive association between extraversion and self-reported habitual physical activity as well as alcohol consumption (even when controlling for gender). Neuroticism was not related to any of the exercise and leisure activity variables. Multiple regression analyses predicted 34% of variance for the depression-enthusiasm and 39% of the variance for the anxiety-contentment measures of affective well-being. Neuroticism (p < 0.001) and avoidance coping (p < 0.05) were the only significant predictors of both anxiety-contentment and depression-enthusiasm. It is concluded that the influence of individual differences such as personality and gender on coping behaviour and well-being is consistent with social learning theory research. Limitations of cross-sectional research designs necessitate caution with inferring causal paths. Recommendations for future research are presented concerning the use and value of repeated measures designs within research into exercise and well-being.

Adaptation, Psychological↗
PubMed2000

Blood hemostasis in exercise and training.

Formation of the blood clot is a slow but normal physiological process occurring as a result of the activation of blood coagulation pathways. Nature's guard against unwanted blood clots is the fibrinolytic enzyme system. In healthy people, there is a delicate dynamic balance between blood clot formation and blood clot dissolution. Available evidence suggests that exercise and physical training evoke multiple effects on blood hemostasis in normal healthy subjects and in patients. A single bout of exercise is usually associated with a transient increase in blood coagulation as evidenced by a shortening of activated partial thromboplastin time (APTT) and increased Factor VIII (FVIII). The rise in FVIII is intensity dependent and continues into recovery. The effects of acute exercise on plasma fibrinogen have yielded conflicting results. Thus, the issue of whether exercise-induced blood hypercoagulability in vitro mirrors an in vivo thrombin generation and fibrin formation remains disputable. Exercise-induced enhancement of fibrinolysis has been repeatedly demonstrated using a wide range of exercise protocols incorporating various exercise intensities and durations. Moderate exercise appears to enhance blood fibrinolytic activity without a concomitant activation of blood coagulation mechanisms, whereas, very heavy exercise induces simultaneous activation of blood fibrinolysis and coagulation. The increase in fibrinolysis is due to a rise in tissue-type plasminogen activator (tPA) and decrease in plasminogen activator inhibitor (PAI). The mechanism of exercise-induced hyperfibrinolysis is poorly understood, and the physiological utility of such activation remains unresolved. Strenuous exercise elicits a transient increase in platelet count, but there are conflicting results concerning the effect of exercise on platelet aggregation and activation. Few comprehensive studies exist concerning the influence of exercise training on blood hemostasis, making future investigation necessary to identify whether there are favorable effects of exercise training on blood coagulation, fibrinolysis, and platelet functions.

Exercise↗
PubMed1999

Exercise induces a change in plasma fibrinogen concentration: fact or fiction?

This study examined the effect of exercise on plasma fibrinogen concentrations with simultaneous measurements of plasma volume changes. Eight moderately active males aged 26.6+/-3.6 years (mean +/- SD) completed maximal (VO2max) and submaximal (75% VO2max for 30 minutes) exercise trials separated by 7 days. Venous blood samples were obtained at rest, immediately postexercise, and following 30 minutes of recovery. Whole blood was analysed for haematocrit and haemoglobin, while citrated plasma was assayed for fibrinogen levels. Values of haematocrit and haemoglobin before and after exercise were utilised for the estimation of plasma volume changes. Plasma volume decreased (p<0.05) immediately following both maximal (-17.7+/-5.1%) and submaximal (-14.3+/-4.1%) exercise. Exercise resulted in decreased plasma fibrinogen levels (maximal exercise: from 266.3+/-14.5 to 222.2+/-23.9 mg x dL(-1); submaximal exercise: from 239.5+/-45.4 to 209.7+/-42.4 mg x dL(-1)) only when postexercise raw data were corrected for the contraction of plasma volume. It is concluded therefore that changes in plasma volume in response to exercise should be taken into account when interpreting exercise effects on plasma fibrinogen concentration.

Adult↗