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C Scheidegger

Publications and source records attributed to C Scheidegger.

23 records · Page 2Linked to original sources
PubMed1980

Protein-bound mono(ADP-ribose) residues in differentiating cells of Dictyostelium discoideum.

Changes in protein-bound mono(ADP-ribose) residues during development of Dictyostelium discoideum were determined. NAD(H) levels and the amounts of the NH2OH resistant and sensitive subfractions of mono(ADPR) were found not to be different between exponentially growing and aggregation-competent cells in which mitosis had ceased. Divergent changes occurred at the differentiation stages following aggregation as indicated by an increase in the ratio of these subfractions from approx. 1 during the growth plase and aggregation competent stage to 2 in the grex, a stage which follows cell aggregation. The fraction of NH2OH sensitive conjugates closely followed the changes in total cellular protein, while the NH2OH resistant ADPR protein conjugates, when based on protein, increased during the stages following aggregation. NAD(H) and NADP(H) levels per unit DNA decreased significantly during this period. The mono(ADPR) to DNA ratio in D. discoideum is comparable to that in proliferating Physarum polycephalum and to non-proliferating adult rat liver. The total amount of mono(ADPR) residues per nucleus is, however, approximately 70-fold higher in the liver, indicating that the quantity of mono(ADPR) residues is more closely related to the size of the eukaryotic genome than to cell proliferation.

Adenosine Diphosphate Ribose↗
PubMed1979

[Absences from school in Basle primary pupils].

In the lower income group children of full-time working mothers have the lowest average of school absences, whereas in the higher income group they have the highest average. School absences of children in the lower income group increase markedly with increasing learning problems which might point out class differences of our schools.

Absenteeism↗
PubMedDate not supplied

Infectious complications in drug addicts: seven-year review of 269 hospitalized narcotics abusers in Switzerland.

In a retrospective survey of patients hospitalized in the Department of Medicine of the University Hospital, Basel, Switzerland, from 1980 to 1986, we found 269 patients with history of past or current drug abuse. The charts of these patients were analyzed for infectious complications according to defined criteria. Heroin was the principal drug consumed by 95%. In 127 patients (47%) at least one infectious complication was diagnosed. In 125 (31%) of 404 admissions, the infectious problem was the main reason for hospitalization. Among the 269 patients, 217 infective episodes occurred. Pulmonary infections were the most frequently occurring (52 episodes). There were 44 cases of viral hepatitis, 30 of human immunodeficiency virus infection, and 25 of minor genital infections. Bone and joint infections and sepsis/endocarditis were diagnosed in seven cases each. The overall mortality was 4.1%; however, only three of the 11 deaths were attributed to infections. Intravenous drug addiction is complicated by a high morbidity because of infections that were seldom lethal during the observed period.

Adolescent↗