[The lactulose challenge. Part 1. On the cholesterol lowering effect of lactulose].
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Biomedical subjects
Publications and source records attributed to C Schumann.
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With the constant high number of abortions, it seems that the propagation of the still little known post coital contraception--as an emergency "brake" the morning after--is urgently necessary. The three known hormonal methods, i.e. the oestrogen method, the gestagen method and the combination method as well as the intentional post coital insertion of an intra uterine device, are discussed as far as the application, advantages and disadvantages are concerned. The combination method, i.e. the application of 0,2 mg ethinylestradiol and 2,0 mg norgestrel seems to be the most recommendable, as it combines a high contraceptive assurance with good tolerance and use. The legal and moral considerations for post coital contraception are discussed.
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Interfacial properties of the outer cell membrane of normal and transformed in vitro cultures of mouse 3T3 cells have been investigated. The contact angles of sessile drops on dried cell preparations were measured and the interfacial tensions derived using the thermodynamic approach introduced by Neumann. Interfacial tensions were found to be within an order of magnitude of those determined for other cell and model membranes. Treatment of cells with calf serum, a stimulant to proliferation, resulted in a decrease in the interfacial tension of normal and transformed cells, whereas use of concanavalin A and its succinylated derivative lead to an increase of interfacial tensions of both cell types. These and further results show a detailed correlation between the growth-regulating effects and the effects on interfacial properties of these proliferation-modifying factors. An interpretation of the results of serum depression of the interfacial tension in terms of a binding equilibrium dependent on the concentration of humoral growth factors in the medium is attempted.
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