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Biomedical subjects

C Searle

Publications and source records attributed to C Searle.

At least 19 recordsLinked to original sources
PubMed1995

Photoemission Study of CO Adsorption on Gd.

Angle-resolved UV photoemission spectroscopy has been used to investigate the interaction of CO with Gd films, grown on W(110). The results suggest the CO absorbs dissociatively, initially forming Gd(2)O(3), with subsequent catalytic oxidation of CO to form carbonate.

Journal Article↗
PubMed1994

Uncertainty and quality of life of adults hospitalized with life-threatening ventricular arrhythmias.

Advances in the management of ventricular arrhythmias have improved patient survival, but not the uncertainty faced by those living with these arrhythmias. Managing the uncertainty in illness is considered essential to the maintenance of well-being and, therefore, quality of life. The purpose of this study was to determine the relationship between uncertainty and quality of life for adults with recurrent ventricular arrhythmias. Using a descriptive correlational design, 22 adults hospitalized with life-threatening ventricular arrhythmias completed questionnaires prior to discharge from the hospital. Data were collected using a demographic questionnaire, the Mishel Uncertainty in Illness Scale, the Quality of Life Index-Cardiac Version, and a single item self-rating scale for amount of worry. Results from the study indicated that greater quality of life for the health and functioning domain was significantly correlated with lower overall uncertainty and less ambiguity. Greater worry about the arrhythmia was associated with increased uncertainty and ambiguity, and poorer quality of life for the health and functioning domain. The results provide support for the aversive nature and negative impact of uncertainty on quality of life for patients with ventricular arrhythmias. Conclusions address clinical and research implications of these findings.

Adult↗
PubMed1989

Human papillomavirus and epithelial ovarian neoplasia.

In contrast to the strong association between human papillomavirus (HPV) and squamous cell carcinoma of the lower female genital tract, no viral DNA had been found in epithelial ovarian carcinoma. Recently, however, R. H. Kaufman, J. Bornstein, A. N. Gordon, E. Adam, A. L. Kaplan, and K. Adler-Storthy [Gynecol. Oncol. 27, 340-349 (1987)] reported the detection of HPV-6 DNA by in situ hybridization in 10 of 12 patients with advanced epithelial ovarian carcinoma. To further investigate the possible association between HPV and epithelial ovarian neoplasia, tumor from 12 patients with epithelial ovarian adenocarcinoma, 3 with epithelial ovarian tumors of low malignant potential, and 3 with epithelial ovarian tumors of low malignant potential, and 3 with epithelial ovarian adenomas was examined for HPV DNA by the Southern hybridization technique. All the tissues were tested under low stringency for HPV-6 and under high stringency for HPV-6, HPV-16, HPV-18, HPV-31, and HPV-35. In addition, all tissues were tested by polymerase chain reaction for the presence of HPV-6 and HPV-11. Of the 12 patients with adenocarcinoma, 5 were poorly differentiated, 4 serous, 1 endometrioid, 1 mucinous, and 1 mixed. The neoplasms were of grades 2-4 with a predominance of stages III and IV (83%). Of the 3 patients with tumors of low malignant potential, all were serous and stage I. Of the 3 patients with adenomas, 1 was mucinous, 1 serous, and 1 Brenner. We were unable to detect HPV-related sequences in any of the specimens. On the basis of these findings, there appears to be no association between HPV and epithelial ovarian neoplasia.

Adenocarcinoma↗
PubMed1984

Transient Brown's syndrome in juvenile chronic arthritis.

A 9-year-old boy with systemic juvenile chronic arthritis and Brown's syndrome (limitation of elevation of the adducted eye due to limitation of movement of the superior oblique tendon) is described. The resolution in association with steroid treatment suggested a transient tenonsynovitis involving the superior oblique tendon as the cause.

Arthritis↗