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C Sebban

Publications and source records attributed to C Sebban.

At least 37 records · Page 2Linked to original sources
PubMed1987

[Quantified electroencephalogram: value in the evaluation of therapy of cerebral aging].

Computerized quantification of electroencephalograms enables pharmacological compounds designed to counteract pathological cerebral aging to be evaluated. The results obtained by this method when substances which sedate or stimulate the central nervous system are used suggest the existence of a negative correlation between neuronal activity and electroencephalographic power. More precisely, the application of this method to pharmacology suggests a relation with the activity of one or several neurotransmission systems. By extension, studies of cerebral aging may benefit from this new technique of cerebral exploration because it allows the demonstration of age related changes in the EEG effect of drugs studied in physiological conditions. Thus we have demonstrated an interaction between the almitrine-raubasine combination and the noradrenergic system in rats. In clinical pharmacology, the evaluation of these two compounds is still liable to numerous experimental biases. The almitrine-raubasine combination was tested in controlled trials in elderly people complaining of intellectual deterioration; the results obtained were fairly similar to those observed in old rats, thus demonstrating an effect on the central nervous system and perhaps also an action on the noradrenergic system in human.

Almitrine↗
PubMed1987

[Low-grade non-Hodgkin's lymphoma in the adult: new therapeutic approaches].

Treatment of disseminated low grade non-Hodgkin's lymphomas (NHL) remains unsolved. Despite an initial high remission rate (50%-70%) with chemotherapy, relapses occur and only 20 to 40% of patients are expected to be free of disease after 10 years. From 1981 to 1984, 113 low grade NHL were studied in order to determine factors influencing survival without progression. In a randomized trial, patients received either PCOP combination or PACOP for 6 months followed by chlorambucil or CVP for 12 months. Histological distribution was: follicular small cleaved cells 70 patients, follicular mixed 31 patients, small cells CLL type 12 patients. Stage distribution was: stage IV 88 patients with 74 bone marrow involvement, stage III 17 patients, stage II with bulky masses 8 patients. Complete response (CR) was observed in 49 patients at the end of treatment. Among the ten variables studied, only stage and the number of sites involved had a significant effect on the probability of achieving CR. Only CR significantly affected the freedom from progression (P less than 0.01). Median survival after progression was 21 months. Recently, alpha recombinant interferon has been proposed as treatment for low grade NHL. Cumulative results from the literature give a response rate of 42% on 139 patients. The response rate was higher in follicular NHL than in the CLL type, and response did not clearly correlate with dose. The CR rate was low (less than 20%) and relapses occurred after stopping therapy. Combined use of interferon and chemotherapy is proposed for future clinical trials.

Adult↗
PubMed1987

Intensive chemotherapy in aggressive lymphomas: updated results of LNH-80 protocol and prognostic factors affecting response and survival.

One hundred patients with aggressive malignant lymphomas treated with the LNH-80 regimen were evaluated for long-term survival and pretreatment characteristics predictive of response and survival. LNH-80 consists of three intensive courses of adriamycin cyclophosphamide vindesine bleomycin (ACVB) followed by sequential consolidation and final intensification. Eighty-four patients went into complete remission (CR), eight had a partial response (PR), three failed to respond, and five died during induction. Twenty-three patients (27%) relapsed, in two of whom a prolonged second remission was obtained. Sixty-three patients are currently alive, two of them with disease. Four patients died in CR. Median survival and median freedom from relapse survival were not reached with a median follow-up of 4 1/2 years. Characteristics negatively associated with response in multivariate analysis were: poor performance status, bone marrow involvement, and two or more extranodal sites of disease. Duration of CR was associated with splenic involvement. Three characteristics were negatively associated with survival in multivariate analysis: age, high grade subtypes, and bone marrow involvement.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1987

Age-related variation of EEG responses to clonidine, prazosin and yohimbine in rats.

The EEG-effects induced by intraperitoneal administration of clonidine, prazosin and yohimbine to 8 and 22 month old rats were compared. Clonidine (0.01 mg/kg) and prazosin (1 mg/kg) increased spectral powers, yohimbine (0.5 mg/kg) decreased them. In the older rats, EEG variations were smaller for prazosin and yohimbine, but larger for clonidine. These findings show that alpha receptor mediated influences on EEG are changed during aging and show that quantified EEG gives a picture of age related changes in the functional state of the neurotransmitter systems.

Aging↗
PubMed1987

Influence of daunorubicin and cytarabine sequencing on the outcome of therapy in acute myelogenous leukemia: a randomized trial.

Ninety-seven patients less than or equal to 70 years of age with previously untreated primary acute myeloblastic leukemia were randomly treated with either the DAT or TAD regimen: daunorubicin (70 mg/m2/day) administered on Days 1-3 (DAT) or 5-7 (TAD) of a 7-day sequence consisting of cytarabine (200 mg/m2/day) and 6-thioguanine (200 mg/m2/day). Complete responders received consolidation, maintenance, and final intensification over 14 months using mostly the same drugs as during induction and administered in the same sequence. The regimens did not significantly differ from each other with regard to toxicity or efficacy. Complete remission rate was 80% in the two groups, and median duration of complete remission was 549 days with DAT and 518 days with TAD.

Adult↗
PubMed1986

Acute leukemia with t(4;11) following treatment for breast cancer.

We report the case of a 51-year-old woman presenting t(4;11) acute undifferentiated leukemia 19 months after initiation of adjuvant radio-chemotherapy for a breast cancer. Morphology of the blasts was FAB L2 and cytochemical and immunological studies were in favor of an undifferentiated leukemia. A possible relationship between t(4;11) leukemia and exposure to carcinogens is discussed.

Acute Disease↗
PubMed1985

[Histological transformation of low malignancy lymphoproliferative syndromes. Clinical and developmental study of 32 cases].

Fourteen out of 283 patients with chronic lymphoid leukaemia, 2 out of 47 with Waldenström's disease and 16 out of 136 with low malignancy lymphoma (follicular with predominant small cleaved cells, mixed follicular with small and large cells, or diffuse lymphocytic) underwent histological transformation of their disease into a highly malignant lymphoma (immunoblastic in 14 of the 32 cases). There are no clinical or biological signs that predict these changes which seem to occur haphazardly in time. Seven patients died within one month of the diagnosis. The classical treatments failed. Complete remission was obtained in 5 cases with the intensive and sequential chemotherapy used for initially aggressive lymphomas.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1985

[Severe quantitative bone marrow insufficiency: results of treatment with high-dose antilymphocyte serum].

Nineteen patients with severe aplastic anaemia were treated with 21 courses of horse antithymocyte globulins (ATG). Changes in haematological parameters were correlated with ATG dosage. One of the 11 patients who received less than 100 mg/kg is still alive after more than 12 months. One of the 10 patients who received more than 100 mg/kg died of infection; in the remaining 9 patients, treatment resulted in increase or even return to normal of haemoglobin, polymorphonuclear and platelet levels. None of these 9 patients relapsed during a median follow-up of 16 months (range: 7 to 35 months). Immediate drug tolerance and serum sickness were unrelated to ATG dosage. These results confirm the therapeutic effectiveness of antithymocytic globulins in severe aplastic anaemia; they also suggest that 150 mg/kg doses are required to obtain satisfactory and long-lasting results.

Adolescent↗
PubMed1977

Heart rate and cardiac function curves. Their dependence on the age of the myocardium and the compliance of the ejection circuit.

Isolated, perfused hearts from 16 rats aged from 13 to 17 months were studied to examine the effects of age and of the compliance of the ejection circuit on heart rate and cardiac function curves. Heart rate was found to diminish both with age and with decreasing compliance of the ejection circuit. Cardiac function curves were also substantially modified by these two factors. It was found that old hearts adapted better to a reduced circuit compliance. This suggests that, in the intact animal, changes in the mechanical properties of the heart muscle may be an adjustment to the reduction in arterial compliance which accompanies ageing.

Adaptation, Physiological↗