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Biomedical subjects

C Seebacher

Publications and source records attributed to C Seebacher.

At least 55 records · Page 3Linked to original sources
PubMed1984

[The HLA system and porphyria cutanea tarda].

Familiar occurrence of porphyria cutanea tarda (P. C. T.) has led to search for genetic markers of this disease. One of the three contradictory studies in literature showed significant increased frequencies of HLA-A3 and -B7 in the P. C. T. These results are important for the hypothesis that a disorder of iron metabolism linked to the HLA system (HLA-A3) supports a manifestations of the disease. Our investigations don't support generally this hypothesis. In 90 P. C. T.-patients significantly higher frequencies of any HLA-A, -B and -C-locus were not to be found. But we found a statistic guaranteed higher frequency of HLA-A9 in the subgroup (n = 34) of alcoholic induced P. C. T. An association between HLA-A9 and liver diseases is reported somewhere else. The higher percentage of HLA-A3 incidence in this group was not significant. Significant higher frequency of HLA-A9 possibly refers to liver diseases by P. C. T. HLA-A3--association is imagineable with iron-over loaded disorder in this group.

Adult↗
PubMed1983

Exercise induces in vivo platelet activation in patients with coronary artery disease and in healthy individuals.

Recently, conflicting results have been published about a possible relationship between platelet activity and exercise-induced myocardial ischemia. The present study was performed to investigate platelet behavior during a graded symptom-limited bicycle ergometer test both in relation to the intensity of exercise and to exercise-induced myocardial ischemia. Plasma concentrations of platelet factor 4 (PF4) and beta-thromboglobulin (beta-TG) were measured by radioimmunoassays in 53 patients who had had acute myocardial infarction 10 weeks before the study and, for comparison, in 9 healthy individuals. In the whole group of the 53 patients there was no significant alteration in platelet-specific proteins during exercise, whereas physical activity induced a 2- to 3-fold increase in beta-TG and PF4 levels in the controls. However, on differentiation of the patients as to their individual exercise performance, significant exercise-associated platelet activation was demonstrable in those who reached more than 75% of their calculated maximal working capacity, whereas no correlation was found between platelet activity and exercise-induced myocardial ischemia. Thus, the results from this study indicate that in vivo platelet activation is a physiological phenomenon which occurs when a certain degree of physical intensity is exceeded, independent of the precipitation of myocardial ischemia.

Adult↗
PubMed1981

[Effects of muscular exercise on non-glucoregulatory hormones (T3, rT3, T4, TSH, prolactin, FSH, LH) in type I diabetics (author's transl)].

In the present investigation the influence of muscular exercise on non-glucoregulatory hormones (T3, rT3, T4, TSH, prolactin) was analyzed in non-ketotic, juvenile-onset type diabetics (JD) in relation of their metabolic control. The plasma hormonal concentrations were measured in 8 well-controlled JD, 8 moderately controlled JD and in 8 healthy subjects, before, during and after a 30 min. bicycle ergometer test of moderate work intensity. The exercise-induced rise in T4, and rT3 was similar in both groups of diabetics and did not significantly differ with that obtained in controls. A significant increase of T3-concentrations occurred only in the controls. Hormone levels of TSH, FSH and LH did not change significantly during exercise in all three groups, whereas prolactin showed a considerable increase (N. S.) in the well-controlled JD-patient group with low blood glucose concentrations. These findings demonstrate that muscular exercise leads to a similar effect on the behavior of T4, rT3, TSH, LH, and FSH concentrations, but not on T3 (no increase) and prolactin in non-ketotic, conventionally treated JD compared with healthy individuals.

Adult↗
PubMed1981

[Comparative examinations of the effect of general and local anesthesia upon the T-lymphocytes in melanoma operations (author's transl)].

We examined the number of T-Lymphocytes in 14 malignant melanoma patients using the sheep erythrocyte rosette test and the PHA stimulation test. These investigations were carried out before the operation under general anesthesia was performed as well as 1, 7, 14, 21, and 28 days after the operation. 16 patients with various large surface skin operations in local anesthesia served as a control group. Among them there were also 5 malignant melanoma cases. The tests preoperatively accomplished yielded normal results (T-lymphocytes 65.7 +/- 2.95%, PHA stimulation 79.01 +/- 1.69%) for all 19 melanoma patients. 24 hours after the operation the average portion of T-lymphocytes decreased in relation to the whole lymphocytes and reached only the level of 53.8 +/- 7.8%. After 7 days it amounted to 57.5 +/- 8.5%, after 14 days to 59.5 +/- 7.8%, after 21 days to 62.3 +/- 5.4% and after 28 days to 62.8 +/- 6.1%. The PHA stimulation was significantly diminished only after 24 hours, but not longer after 7 days. A correlation between the diminution of T-lymphocytes observed 14 and more days after the operation and the duration of the general anesthesia may be suggested in single cases. -- Patients operated under local anesthesia showed after 2 and 24 hours a significant diminution of T-lymphocytes. After 7 days the values had returned to normal levels (66.7 +/- 5.9%).

Adult↗
PubMed1981

[Effect of muscular exercise and metabolic control on cortisol, growth hormone, plasma-epinephrine and plasma-norepinephrine in type-I diabetics [author's transl)].

In the present study we investigated the influence of muscular exercise on stress-hormones (cortisol, growth hormone, epinephrine, norepinephrine) in nonketotic, juvenile-type diabetics (JD) in relation to the degree of metabolic control. The plasma-hormone-concentrations were measured in 8 well controlled JD, 8 moderately controlled JD and in 8 healthy subjects, before, during and after a 30 min bicycle ergometer test of moderate work intensity. The exercise induced rise in cortisol, epinephrine and norepinephrine wa similar in both groups of diabetics and not significantly different compared with controls. In healthy subjects growth hormone levels rose significantly with the onset of exercise, whereas in both patient groups maximal growth hormone concentrations were found at the end of the ergometer test. In moderately controlled JD, however, growth hormone concentrations were significantly higher than in well controlled JD. The results demonstrate that muscular exercise shows a similar effect on cortisol, epinephrine and norepinephrine, but not on growth hormone concentrations in nonketotic, conventionally treated JD compared with controls.

Adult↗