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Biomedical subjects

C Shieh

Publications and source records attributed to C Shieh.

4 recordsLinked to original sources
PubMed2001

Lipid remodeling in mouse liver and plasma resulting from delta6 fatty acid desaturase inhibition.

Electrospray/tandem mass spectrometry was used to quantify lipid remodeling in mouse liver and plasma during inhibition of polyunsaturated fatty acid synthesis by the delta6 fatty acid desaturase inhibitor, SC-26196. SC-26196 caused increases in linoleic acid and corresponding decreases in arachidonic acid and docosahexaenoic acid in select molecular species of phosphatidylcholine, phosphatidylethanolamine, and cholesterol esters but not in phosphatidylserine, phosphatidylinositol, or triglycerides. For linoleic acid-, arachidonic acid-, and docosahexaenoic acid-containing phospholipid species, this difference was, in part, determined by the fatty acid at the sn-1 position, namely, palmitic or stearic acid. An understanding of phospholipid remodeling mediated by delta6 desaturase inhibition should aid in clarifying the contribution of arachidonic acid derived via de novo synthesis or obtained directly in the diet during inflammatory responses.

Animals↗
PubMed2001

Concept analysis of well-being.

Traditionally, mortality and morbidity were considered two important indicators of health outcome. Until recently, the measurement of health outcome focused on individuals' subjective perceptions of well-being. Well-being has been popularly used in many scientific disciplines. The definitions of well-being, however, were diverse and inconsistent in previous literature. The ambiguous concept used in research study will impede the development of knowledge and theory. Concept analysis, therefore, is necessary to synthesize the existing views of well-being and distinguish it from other concepts to explicate the meaning of well-being.

Health↗
PubMed2001

What do we know about maternal-fetal attachment?

A review of the literature suggests that there are three critical attributes related to the concept of maternal-fetal attachment, including cognitive, affective, and altruistic attachment. Cognitive attachment is the desire to know the baby. Affective attachment is the pleasure associated with thoughts of or interaction with the fetus. Altruistic attachment refers to a desire to protect the unborn child. Existing measurements on maternal-fetal attachment are developed based on low-risk and white pregnant women and previous research has not yet resulted in a consistent theoretical model. Future research should focus on development of culturally sensitive instruments and combining qualitative and quantitative measures to broaden theoretical understanding of the concept. Nursing assessment of maternal-fetal attachment is an on-going process. The nurse's role is to reassure those who have developed attachment to their fetuses and to motivate those who are unaware of or unconcerned about their attachment to their fetuses. Collecting data from different attributes of attachment helps nurses identify each woman's attachment patterns and areas of concern.

Affect↗