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Biomedical subjects

C Sicard

Publications and source records attributed to C Sicard.

At least 19 recordsLinked to original sources
PubMed1997

Evaluation of eye irritation potential: statistical analysis and tier testing strategies.

Eye irritation testing, specifically the Draize test, has been the centre of controversy for many reasons. Several alternatives, based on the principles of reduction, refinement and replacement, have been proposed and are being used by the industry and government authorities. However, no universally applicable, validated non-animal alternative(s) is currently available. This report presents a statistical analysis and two testing approaches: the partial least squares multivariate statistical analysis of de Silva and colleagues from France, the tier-testing approach for regulatory purposes described by Gerner and colleagues from Germany, and the three-step tier-testing approach of the US Interagency Regulatory Alternatives Group described by Gupta and Hill. These approaches were presented as three separate papers at the November 1993 Interagency Regulatory Alternatives Group (IRAG) Workshop on Eye Irritation Testing; they have been summarized and combined into the following three-part report. The first part (de Silva et al.) presents statistical techniques for establishing test batteries of in vitro alternatives to the eye irritation test. The second (Gerner et al.) and third (Gupta and Hill) parts are similar in that they stage assessment of information by using a combination of screening information and animal testing to effect reductions in animal use and distress.

Animal Testing Alternatives↗
PubMed1997

Effect of pelvic tilt on lumbar spine geometry.

The purpose of this study was to use a noninvasive method to determine the effect of pelvic tilt on the lumbar spine geometry in the sagittal plane. Five healthy male subjects were instructed in performing active forward and backward pelvic tilt manoeuvres in the standing position. The lumbar spine geometry (severity of lordosis, pelvis and lumbar vertebrae orientations) was estimated with a lumbar spine geometric model. The voluntary backward pelvic tilt succeeded in reducing the depth of the lumbar spine curvature, but the forward tilt did not change it. Both pelvic tilt manoeuvres influenced the absolute orientations of the lower lumbar vertebrae and the relative orientations of some lumbar vertebrae. Interestingly, the L5/S1 joint showed was little affected by the pelvic tilt manoeuvres.

Adult↗
PubMed1993

A geometric model of the lumbar spine in the sagittal plane.

This article describes a geometric model using the skin profile and five anthropometric measurements to estimate the position of S1, T12, and all lumbar vertebrae for all postures assumed in the sagittal plane. This method involves a normalization process by which different skin profiles can be compared between postures and individuals. The skin profile is transformed by taking the differences with the lumbar spine into consideration. The model was developed and validated with 20 and 7 subjects, respectively. An error analysis shows an adequate level of accuracy for the absolute (1.68-1.82 cm) and relative (0.32-0.54 cm) linear positions of vertebrae as well as their absolute (2.6-6.7 degrees) and relative (1.4-3.6 degrees) angular positions except for T12; however, the validity of the model was limited to specific angular motions in flexion for the pelvis (12 +/- 3%), the entire lumbar spine (14 +/- 13%) and the intervertebral motion of L4/L5 (13 +/- 10%). The data obtained are very useful, especially in models designed to evaluate loadings on the lumbar spine.

Adult↗
PubMed1990

[Epilepsy-acquired aphasia syndrome with psychosis. Report of a case ].

We report the case of a boy whose development was normal until the age of three when regression with loss of speech occurred. Other anomalies included eating and sleep disorders, sterotyped behavior disorders, suggesting infantile psychosis. The electroencephalogram evidenced paroxysmal anomalies, particularly during sleep, with no clinical seizures. The diagnosis of epilepsia-acquired aphasia syndrome (Landau-Kleffner syndrome) was made. The psychotic disorders were not considered as a differential diagnosis but rather as intertwined with the elements of the syndrome. The relationship between acquired aphasia and psychosis are discussed.

Aphasia↗
PubMed1986

[Comparison of the EEG and computerized tomography findings in 500 patients hospitalized in the neurology clinic of the Salpêtrière].

A comparative EEG and CT scan Study of 500 inpatients was performed. Patients were divided into four groups: 82 patients (16.5%) had normal EEG and CT scan; 92 patients (18.5%) had normal EEG but abnormal CT scan; 75 patients (15%) had abnormal EEG and normal CT scan; 251 patients (50%) had both EEG and pathologic CT scan alterations. Among the 500 patients, 326 EEG (65%) and 343 CT scan (69%) were abnormal. In 167 cases (33%) only one examination was abnormal. This finding may be considered as indicative of the complementary role for both techniques. For each group, the main clinical features were underlined: objective neurologic syndrome, seizures, psychiatric conditions, subjective complaint and headache. In groups with a pathologic CT scan and pathologic EEG, a percentage of 74 showed a clear neurological nosology. In 41% of these patients, lateralisation and localisation were much easier, owing to the presence of a single lesion. This study emphasised that electroencephalography is useful in temporal pathologies and in determination of the epileptic frame, whereas CT scan is useful in subcortical lesions in fronto-parietal lesions.

Adolescent↗
PubMed1985

Method for assessment of experimental allergy in guinea pigs adapted to cosmetic ingredients.

2 protocols are presented to predict and assess allergic reactions after application of chemicals or cosmetic products, either raw materials or finished products. The first is an open epidermal induction and challenge, the intensity of the reaction being maximized by injecting Freund's complete adjuvant into the foot pad. The second allows detection of weaker allergens and is a quasi-intradermal induction: both the adjuvant and test substance are injected into the foot pad. In both protocols, the challenge consisted of a single topical application in the lumbar region of 10 microliter of test substance and components, allowing study of cross-sensitization, the large surface available permitting 6 different contacts.

Administration, Topical↗
PubMed1977

Toxic encephalopathy due to ingestion of bismuth salts: clinical and EEG studies of 45 patients.

Forty-five patients taking bismuth subnitrate orally for therapeutic reasons were admitted to hospital with a myoclonic encephalopathy of acute onset. The clinical features were similar, mostly with mental confusion, disorder of walking and standing, dysarthria, and myoclonic jerks. In 31 cases the EEG showed a characteristic pattern, not previously recognised, which assisted differential diagnosis.

Adult↗
PubMedDate not supplied

[E.E.G. changes in 15 patients with bismuth encephalopathy (author's transl)].

The authors describe the E.E.G. changes found in 15 cases of iatrogenic encephalopathy caused by bismuth salts. All the patients had been taking bismuth, for periods varying from 6 weeks to 30 years, in doses from 5 to 20 g per day. The clinical picture included mental confusion to varying degrees, disturbances of standing and walking, myoclonus, dysarthria, and convulsions in 5 cases. Myoclonic jerks were not occompanied by E.E.G. paroxysmal features in any of the cases observed. Eleven of the patients presented similar E.E.G. findings at one time or another during the course of the condition: monomorphic, stable 4-6 c/s activity, present bilaterally in the temporo-fronto-rolandic regions, unaffected by eye opening and by photic stimulation. In the other four patients, the above E.E.G. features were not found (recording performed too early or too late? co-existing electrical or metabolic disturbances? post-critical recording?).

Aged↗
PubMedDate not supplied

[Electro-encephalographic study in 25 patients with Creutzfeldt-Jakob's disease (author's transl)].

Standard EEG tracings were recorded in 25 patients with anatomically confirmed Creutzfeldt-Jakob's disease. A total of 82 recordings were studied, and were found to conform with those previously described. More particularly, the periodic paroxystic tracing described by Nevin in 1954 was observed in 16 cases, but these were of late onset, frequent, and non-specific. By adopting the anatomical classification described by Daniel (1972), the authors were able to obtain some evidence of electro-anatomical correlations in some cases, but confirmation by means of a larger series of patients is necessary.

Adult↗