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C Sigg

Publications and source records attributed to C Sigg.

42 records · Page 3Linked to original sources
PubMed1980

[Bowenoid papulosis of the anal genital region: a new disease?].

A report is presented on a 28-year-old female patient who underwent surgery several times for recurring papuloverrucous alterations in the anal-genital region. Microscopically, acanthosis with bowenoid dysplasia was found. Electronmicroscopic examination showed similar alterations to those in Bowen's disease of the skin. No virus from skin lesions or from fluor vaginalis was found. This disease picture can be easily classified as the bowenoid papulosis of the anal-genital region which has been newly described in the last few years. The etiology is unknown at this time, and no definite prognosis is possible. The available observations are discussed and the therapeutic possibilities weighed.

Adult↗
PubMed1980

[Prognostic changes in juvenile abdominal non-Hodgkin's lympomas (NHL)].

From 1964-1978 primary non-Hodgkin's lymphoma was diagnosed and treated in 15 children (13 boys and 2 girls). In the 10 patients treated up to 1974, median survival was only 4 months (the longest being 16 months). Since 1974 all such patients have been put on high-dose combined chemotherapy as early as possible. Of 5 children thus treated, 3 have survived for 60, 26 and 11 months respectively and are still alive disease-free. The other two died after 4 1/2 and 5 1/2 months respectively: both had very widespread disease at diagnosis and chemotherapy was delayed by postoperative complications. The 4 most recent tumors have been classified immunologically: 3 were of the B-cell type and exhibited the classic "Burkitt-type" morphology. Two of these patients are alive and well. Although so small a patient material allows no firm conclusions, the authors feel that early intensive chemotherapy may be curative even in this poor-prognosis group of intraabdominal non-Hodgkin's lymphoma.

Adolescent↗
PubMed1979

[Classification of tubular testicular atrophies in the diagnosis of sterility. Significance of the so-called "bunte Atrophie"].

In the course of testicular biopsies from 2317 patients in the years 1969--1978 at the Institute of Pathology of Zurich University, 1165 cases with tubular atrophy were retrospectively examined and classified on the basis of distribution of atrophy on the one hand and degree of atrophy (progressive depopulation) on the other. In virtue of this histological classification, an attempt was made to provide an absolutely or relatively reliable statement respecting the fertility situation, which was possible in 25% of the cases. In the group of the so-called "bunte Atrophie" an alteration could be described which is of interest not only because it accounts for a quarter of all testicular atrophies but also because there is a difference between the slight histological alterations and the obviously serious clinical consequences. It was possible to prove that an increase in the atrophy grade characterized by loss of spermatids is already responsible for rapid shrinkage of tubulus diameter in this group.

Atrophy↗
PubMedDate not supplied

Quantitative and ultrastructural study of germinal epithelium in testicular biopsies with "mixed atrophy".

In 17 cases of male sterility with so-called "mixed atrophy" in testicular biopsies, the germinal epithelium was investigated by quantitative as well as by ultrastructural means. In 13 cases, the number of spermatids only was reduced, in 2 cases earlier stages of germinal cells were diminished also. Normal quantitative data were found in biopsies of 2 patients. Among ultrastructural alterations various disturbances of the acrosome were dominant. Additional ultrastructural findings in spermatids included binucleate forms and lack of mitochondrial sheaths in the middle-piece. The largely uniform changes in the tunica propria (fibrosis of the innermost layers, extensive changes of the basement membrane) were considered to be at least one of the cofactors responsible for the alterations of the germinal epithelium.

Adult↗
PubMedDate not supplied

[Cytologic classification of immature germ cells in the spermatological "syndrome" of increased desquamation of spermatogenic cells].

The spermatological phenomenon of increased exfoliation of immature germ cells (IGC) not commonly known until now, can be defined quantitatively as a number of above 4% IGC in relation to the sperm count. The variable aspect of premature germ cells may be confusing and their degenerative alterations complicate definite classification. Items for the classification of IGC have been elaborated employing comparative cytological studies. Based on these criteria exfoliated IGC within the ejaculate can be grouped into: cells reliably allied to spermatogenesis; cells probably allied to spermatogenesis; cells not exactly classifiable by conventional cytology. Analysing the ejaculates of 20 patients with increased exfoliation of IGC (16-50%), we mainly found cells exfoliated from the adluminal cell compartment of seminiferous tubules (spermatocytes II and spermatids). During conventional light microscopy about one third of the "round cells" in ejaculate smear preparations remained unclassifiable. Pathogenetic reasons of increased output of IGC are unclear so far. This phenomenon, usually accompanied by asthenozoospermia as well and mild to severe teratozoospermia, is very often also combined with decreased sperm counts (5-20 mio/ml ejaculate).

Humans↗