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Biomedical subjects

C Signorini

Publications and source records attributed to C Signorini.

At least 55 records · Page 3Linked to original sources
PubMed1975

[Human chorionic somatommamotropins (HCS or HPL) : radioimmunologic determination and clinical significance].

The AA. have studied a new standardized radioimmunologic method for the routine determination of HCS. All the steps of the analysis have been studied, in particular those concerning the reability test and the precipitation of the complex with PEG. The best conditions were found when PEG 6000 is used at a concentration between 14-16 g in 100 ml (v/w), dissolved in veronal buffer, pH 7.4--9.4, with a dilution of protein (bovine serum) 1:4 in the incubation mixture. The reability test have given very good results. The c.p.m. of the analysis are plotted with a logit plot by computer which directly gives the values in ng/ml of the hormone in the plasma sample. The results obtained with this method are compared with those of the literature; the most striking difference in the present method appears in the last trimester of pregnancy in which the result have a low S.D. and can give a good help in clinical management of pregnant patients.

Abortion, Threatened↗
PubMed1975

[Diazoxide test in the diagnosis of arterial hypertension: modifications in the levels of renin and aldosterone in blood of patients with various restrains of the renal function].

The AA. have applied the diazoxide test for the screening of primary hiperaldosteronism to 22 nephropatic patients suffering from hypertension and with different degrees of renal function. In 22 patients an increase in PRA and aldosterone values always followed the diazoxide infusion. Only one patient, likely suffering from primary aldosteronism, showed no increase in PRA and aldosterone values. The diazoxide infusion had no influence on renal, pancreatic and cardiovascular function. Therefore, this can be considered as a valid test easy to be performed in a short time, also in nephropatic patients who are very sensitive to pharmacological noxae.

Adolescent↗