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Biomedical subjects

C Simard

Publications and source records attributed to C Simard.

At least 91 records · Page 5Linked to original sources
PubMed1987

[The mirror broke : Oedipe has aged, Beginning of a reflection on aging and otherness.].

The "mirror phase" is characterized by a child's recognition of his own image in the mirror and simultaneous perception of approval by the adult, whose reflection is equally discovered. In contrast to this phase, we identify an experience that takes place in old age: the experience referred to in this article as the < >, which occurs when the image reflected by the mirror no longer matches the expectations of the subject. This experience raises doubts concerning non only the relation of the subject with himself, but also with the other, who, ever since the "mirror phase", has supported the subject's identity. Encountering alterity, the process of discovering one's self as different and of confronting an other with whom similarities no longer hold true, is the crux of the "shattered mirror' ' experience and the basis for uprooting narcissist complacency. The dynamics of alterity therefore favour revealment (illustrated by the tragedy of "Oedipe à Colone", while the outcome of the "shattered mirror" experience ranges between distress and reduced alienation.

English Abstract↗
PubMed1986

Prediction of leisure time exercise behavior among a group of lower-limb disabled adults.

The aim of this study was to predict leisure time exercise behavior among a group of 62 lower-limb disabled adults. The theory of reasoned action proposed by Fishbein (Fishbein & Ajzen, 1975) provided a framework for the study. Variables measured included the Fishbein model variables, habit, education, disability type, fitness level, and a 7-day follow-up of exercise behavior. Some 35% of the variance in exercise behavior could be explained; intention was the strongest predictor (.31, p less than .05). In comparison, the ability to predict intentions to exercise by using the other variables was quite poor, with only 7% of the variance explained by habit. None of the Fishbein model variables contributed to this prediction. These results indicated the importance of specific factors, such as the strength of the exercise habit and the cause of disability, on exercise behavior.

Adult↗
PubMed1986

Somatostatin and adrenocorticotrophic hormone like immunoreactivity in small cell carcinoma of the lung.

The immunocytological detection of adrenocorticotrophic hormone (ACTH) and somatotropin release inhibitor factor (SRIF) like immunoreactivity was carried out on tumour cells from bronchial brush smears in 39 cases of lung tumours. Results obtained were compared with the cytological and histological diagnosis and confirmed the high incidence of ACTH synthesis by malignant bronchial carcinoma cells: the same phenomenon also seems to occur for somatostatin. The concomitant detection of ACTH and SRIF like immunoreactivity seems to be highly suggestive of small cell carcinoma and indicates that the immunocytological detection of hormones carried out at the same time as cytological examination can improve the accuracy of the diagnosis.

Adrenocorticotropic Hormone↗
PubMed1986

Chemical DNA sequencing in the opposite direction to the dideoxy chain termination method, using a single preparation of M13 single-stranded DNA.

A strategy has been developed allowing the use of a single preparation of single-stranded DNA clones for chemical DNA sequencing in the opposite direction to the classical dideoxy chain termination method. Oligonucleotide complementary to the 5'-end of the multipurpose cloning sequence, with the proper restriction enzyme, is used to cleave specifically the molecules to expose a unique 5'-end, upstream to the inserted DNA, for the kinase labeling reaction. No further treatments are necessary before Maxam-Gilbert chemical sequencing reactions.

Base Sequence↗
PubMed1985

Enzymatic adaptations to suspension hypokinesia in skeletal muscle of young and old rats.

Hindlimb hypokinesia was induced in young and old rats. After 3 weeks, the activities of five enzymes have been measured in soleus and medial gastrocnemius muscles. Soleus showed increased activity of hexokinase and decreased activity of phosphofructokinase, lactate dehydrogenase and malate dehydrogenase in both groups. The activity of 3-hydroxyacyl-CoA-dehydrogenase was decreased in the old muscle. Medial gastrocnemius showed decreased activity of phosphofructokinase and lactate dehydrogenase in both groups. The activity of 3-hydroxyacyl-CoA-dehydrogenase was decreased in the old muscle whereas hexokinase increased its activity in the young one. It is concluded that suspension hypokinesia results in changes at the enzymatic level. These changes appear to be related to the age of the muscle and to its fibre composition.

Adaptation, Physiological↗
PubMed1985

Enzymatic activities in slow and fast denervated old rat muscles.

The activities of five enzymes have been studied quantitatively in denervated extensor digitorum longus, gastrocnemius and soleus muscles of 24-month-old rats. The results have been compared with those obtained from normal muscles of a similar age group of rats. Three weeks after denervation, the activity of hexokinase was increased in gastrocnemius and extensor digitorum longus. Phosphofructokinase, lactate dehydrogenase, malate dehydrogenase and 3-hydroxyacyl-CoA-dehydrogenase showed decreased activities. These results suggest that enzyme which represents glucose uptake increased its activity in fast muscles and that enzymes for anaerobic glycolysis, lactate fermentation, citric acid cycle and beta-oxidation had a decreased activity in slow and fast muscles.

3-Hydroxyacyl CoA Dehydrogenases↗
PubMed1985

[Intravascular papillary hemangioendothelioma. 4 case reports with oral localization].

The authors report four cases of papillary intravascular haemangioendothelioma of P. Masson located on the mucosa of the cheek, lip or tongue. They always presented as a painless submucosal blueish nodule, more or less elevated and firm, appearing as a thrombosed angioma. As a rule, the size was less than one centimeter. Pathological examination shows an angiomatous papillary neoformation, enclosed within a swollen veinous cavity. Diagnosis is easy on an operative specimen. However, on a small biopsy specimen, a capillary angioma, or a malignant haemangioendothelioma may be more difficult to eliminate. Surgical removal, even partial, will allow complete healing.

Adult↗
PubMed1984

[Leukemoid eosinophilic reaction in angioimmunoblastic adenopathy].

A case of eosinophilic leukemoid reaction is described. This picture is seldom encountered during the course of angio-immunoblastic adenopathy. After reviewing various diagnoses and pointing out similar cases of the literature, the authors discuss the possible pathophysiologic mechanisms of eosinophilia in this disorder.

Aged↗
PubMed1983

[Glomerular lesions renal transplant patients excluding recurrence of glomerulopathy].

The authors report their experience with glomerular lesions after renal transplantation, but exclude recurrent glomerulonephritis. Fourteen cases (3 membranous glomerulopathies and eleven allograft glomerulopathies) are discussed in relation to 98 recipients of 105 renal allografts. Two patients with membranous glomerulopathy had HBs antigen in their serum. A poor graft prognosis is observed in 2 of 3 patients. Among eleven recipients who presented with allograft glomerulopathy, two groups are clearly defined with very different graft prognosis. The severity of the vascular lesions was the sole difference between these two groups. The possible physiopathologic mechanisms of allograft glomerulopathy are discussed. It is worth noting that the role of vesico-ureteric reflux is not a prominent feature of this study.

Adult↗
PubMed1983

Microbial investigation of the air in an apartment building.

The microbial and viral flora in the ventilating ducts of an apartment building was evaluated. Several types of sampler (slit sampler, Andersen sampler, large volume air sampler) were used to evaluate the hourly, weekly and seasonal variation of this flora. The mean bacterial concentration was 17.2 e.f.u./m3 with a maximum level at 07.30 h (41.3 c.f.u./m3) and a minimal concentration in the early afternoon (8 c.f.u./m3). The bacterial concentration observed correlated with the relative humidity in the air-ducts although there were no seasonal differences. The bacteria were mainly gram-positive cocci (73.5%) represented by a large number of Micrococcaceae (47.1%); gram-positive bacilli accounted for 14.2% of the isolates, gram-negative bacilli 12.0% and gram-negative cocci 0.3%. The majority of the bacteria-carrying particles were in the respirable range with 80.4% of them being less than 5 microns. The methods used did not result in the isolation of viruses during the winter sampling period.

Air Microbiology↗
PubMed1983

[Chronic atrophic gastritis with carcinoid tumor and microcarcinoidosis. Report of a case with immunohistochemistry and ultrastructure study].

Gastric endoscopy of a 40 year old woman suffering from ill-defined epigastralgy revealed a carcinoid tumor apparently located at the mucous membrane. The tumor was neither argyrophil nor argentaffin. Immunohistochemical tests for VIP, gastrin and serotonin were negative. Biological examinations indicated hypochrome anemia and hypergastrinemia (greater than 800 pg/ml). The excision was completed by a gastrectomy of 2/3 with a Pean anastomosis. No residual tumor was detected but the fundic mucous membrane showed considerable atrophic gastritis together with a marked hyperplasia of endocrine cells giving an aspect of microcarcinoidosis. Immunohistochemical studies showed that most of the cells produced serotonin while a few cells produced gastrin or VIP. Control biopsies of the stump showed similar hyperplasia of the endocrine cells and ultrastructural studies confirmed the polymorphism of the islets. The present observation is compared to analogous cases cited in the literature. The pathogenic mechanism possibly linked to the capacity of gastrin in stimulating endocrine cells is discussed. The prognosis in these carcinoid tumors appears to be the same as in other gastric carcinoid tumors. In particular, a recent observation (Goldman et al., 1981) illustrated their aptitude to lead to metastases.

Adult↗